Melatonin and its agonist ramelteon in Alzheimer's disease: possible therapeutic value (Q34416921)

2 August 2017

1 reference

title

Melatonin and its agonist ramelteon in Alzheimer's disease: possible therapeutic value (English)

1 reference

Seithikurippu R. Pandi-Perumal

2 August 2017

0 references

0 references

3

object named as

Seithikurippu Pandi-Perumal

1 reference

2 August 2017

Venkatramanujam Srinivasan

1

1 reference

2 August 2017

Charanjit Kaur

2

1 reference

2 August 2017

Gregory M Brown

4

1 reference

2 August 2017

Daniel P Cardinali

5

1 reference

2 August 2017

8 December 2010

1 reference

International journal of Alzheimer's disease

2 August 2017

1 reference

2 August 2017

2011

1 reference

2 August 2017

741974

1 reference

Creative Commons Attribution 3.0 Unported

2 August 2017

start time

1 January 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Effects of melatonin on wortmannin-induced tau hyperphosphorylation

6 July 2018

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Effect of melatonin on calyculin A-induced tau hyperphosphorylation.

6 July 2018

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Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist

6 July 2018

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6 July 2018

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6 July 2018

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Protective effect of melatonin on beta-amyloid-induced apoptosis in rat astroglioma C6 cells and its mechanism

6 July 2018

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Neural stem cells express melatonin receptors and neurotrophic factors: colocalization of the MT1 receptor with neuronal and glial markers

6 July 2018

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A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression

6 July 2018

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Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans

6 July 2018

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A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Treatment of sleep disturbance in Alzheimer's disease

6 July 2018

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6 July 2018

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The use of melatonin in Alzheimer's disease.

6 July 2018

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Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy

6 July 2018

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The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes

6 July 2018

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An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease

6 July 2018

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Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons

6 July 2018

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More than a marker: interaction between the circadian regulation of temperature and sleep, age-related changes, and treatment possibilities

6 July 2018

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

6 July 2018

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Alzheimer beta protein mediated oxidative damage of mitochondrial DNA: prevention by melatonin

6 July 2018

1 reference

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Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells

6 July 2018

1 reference

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Potent neuroprotective properties against the Alzheimer beta-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid

6 July 2018

1 reference

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Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-waking.

6 July 2018

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Indole-3-propionate: a potent hydroxyl radical scavenger in rat brain.

6 July 2018

1 reference

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Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment

6 July 2018

1 reference

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Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

Chronobiotics--drugs that shift rhythms

6 July 2018

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The orphan receptor family RZR/ROR, melatonin and 5-lipoxygenase: an unexpected relationship

6 July 2018

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The melatonin rhythm: both a clock and a calendar

6 July 2018

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A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

6 July 2018

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Hydrogen peroxide mediates amyloid beta protein toxicity

6 July 2018

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Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

6 July 2018

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Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor

6 July 2018

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6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

In vitro and in vivo formation of two new metabolites of melatonin.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

Plasma concentrations of melatonin in man following oral absorption of different preparations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

Melatonin effects on brain. Interaction with microtubule protein, inhibition of fast axoplasmic flow and induction of crystaloid and tubular formations in the hypothalamus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

The role of oxidative stress in the aging process.

6 July 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Sleep disturbances in Alzheimer's disease and other dementias

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Increased vascular permeability and nitric oxide production in response to hypoxia in the pineal gland.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Melatonin reduces hippocampal beta-amyloid generation in rats exposed to chronic intermittent hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Melatonin is released in the third ventricle in humans. A study in movement disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Role of CSF in the transport of melatonin

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Regional concentrations of melatonin in the rat brain in the light and dark period.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Cytochrome P450 isoforms involved in melatonin metabolism in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Polysomnographic study of the effect of melatonin on sleep in elderly patients with chronic primary insomnia.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

The neuroprotective activities of melatonin against the Alzheimer beta-protein are not mediated by melatonin membrane receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Formation of aberrant phosphotau fibrillar polymers in neural cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Melatonin prevents cytoskeletal alterations and oxidative stress induced by okadaic acid in N1E-115 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Astrocytes contribute to neuronal impairment in beta A toxicity increasing apoptosis in rat hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Beta-amyloid modulates tyrosine kinase B receptor expression in SHSY5Y neuroblastoma cells: influence of the antioxidant melatonin

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Amyloid-beta neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3beta, tau and neuroinflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Effect of melatonin on changes in locomotor activity rhythm of Syrian hamsters injected with beta amyloid peptide 25-35 in the suprachiasmatic nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Circadian and sleep disturbances in the elderly.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Daily rhythm of serum melatonin levels and effect of light exposure in patients with dementia of the Alzheimer's type.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Changes in endocrine circadian rhythms as markers of physiological and pathological brain aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Monozygotic twins with Alzheimer's disease treated with melatonin: Case report.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Melatonin for treatment of sundowning in elderly persons with dementia - a preliminary study.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Actigraphy in agitated patients with dementia. Monitoring treatment outcomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

REM sleep behaviour disorder treated with melatonin in a patient with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the "master clock".

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Cognitive effects of exogenous melatonin administration in elderly persons: a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Possible therapeutic value of melatonin in mild cognitive impairment: a retrospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Effects of ramelteon on patient-reported sleep latency in older adults with chronic insomnia.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

A 2-night, 3-period, crossover study of ramelteon's efficacy and safety in older adults with chronic insomnia.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

The effects of ramelteon in a first-night model of transient insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Cerebrovascular melatonin MT1-receptor alterations in patients with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Stimulatory effects of a melatonin receptor agonist, ramelteon, on BDNF in mouse cerebellar granule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2011%2F741974

Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer's disease.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

Uncoupling proteins and sleep deprivation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease: an open-label pilot study using actigraphy

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

Melatonin enters the cerebrospinal fluid through the pineal recess

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

Melatonin treatment stabilizes chronobiologic and cognitive symptoms in Alzheimer's disease.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004402

Age and gender effects on the pharmacokinetics and pharmacodynamics of ramelteon, a hypnotic agent acting via melatonin receptors MT1 and MT2

27 October 2018

1 reference

12 December 2020

Lower tryptophan:phenylalanine ratios in culture media increase medium: pineal melatonin ratios in early dark but not late light phase

1 reference

12 December 2020

Decreased melatonin synthesis in patients with coronary artery disease

1 reference

12 December 2020

Improvement of sleep quality by melatonin

1 reference

12 December 2020

Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease

1 reference

12 December 2020

A novel melatonin metabolite, cyclic 3-hydroxymelatonin: a biomarker of in vivo hydroxyl radical generation

1 reference

12 December 2020

Identifiers

DOI

10.4061/2011/741974

1 reference

2 August 2017

1 reference

2 August 2017

1 reference