Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1. (Q34404559)

2 August 2017

Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1. (English)

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2 August 2017

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Kanae Iijima-Ando

1

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2 August 2017

Michiko Sekiya

2

1 reference

2 August 2017

Akiko Maruko-Otake

3

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2 August 2017

Yosuke Ohtake

4

1 reference

2 August 2017

Emiko Suzuki

5

1 reference

2 August 2017

Bingwei Lu

6

1 reference

2 August 2017

Koichi M Iijima

7

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2 August 2017

30 August 2012

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2 August 2017

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2 August 2017

8

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2 August 2017

8

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2 August 2017

e1002918

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Creative Commons Attribution 4.0 International

2 August 2017

start time

30 August 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3431335/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity

6 July 2018

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Tau reduction prevents Abeta-induced defects in axonal transport.

6 July 2018

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Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease

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Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease

6 July 2018

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Bazooka is required for polarisation of the Drosophila anterior-posterior axis

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A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration

6 July 2018

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Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases

6 July 2018

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Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease

6 July 2018

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Animal models reveal role for tau phosphorylation in human disease

6 July 2018

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Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

6 July 2018

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Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

6 July 2018

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Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease

6 July 2018

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S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury

6 July 2018

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The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility

6 July 2018

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Tau inhibits anterograde axonal transport and perturbs stability in growing axonal neurites in part by displacing kinesin cargo: neurofilaments attenuate tau-mediated neurite instability

6 July 2018

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Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

6 July 2018

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A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

6 July 2018

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

6 July 2018

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Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.

6 July 2018

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Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid

6 July 2018

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The genetics of axonal transport and axonal transport disorders

6 July 2018

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Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent

6 July 2018

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The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking

6 July 2018

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The axonal transport of mitochondria.

6 July 2018

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Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

6 July 2018

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Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neurons

6 July 2018

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Genetic modifiers of tauopathy in Drosophila.

6 July 2018

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

6 July 2018

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Tau is essential to beta -amyloid-induced neurotoxicity

6 July 2018

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Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

6 July 2018

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

6 July 2018

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Neurodegenerative tauopathies

6 July 2018

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6 July 2018

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Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

6 July 2018

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Drosophila adducin regulates Dlg phosphorylation and targeting of Dlg to the synapse and epithelial membrane.

6 July 2018

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Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines

27 October 2018

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Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Expression of beta-amyloid induced age-dependent presynaptic and axonal changes in Drosophila.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Study of tauopathies by comparing Drosophila and human tau in Drosophila.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Mitochondria are redistributed in Drosophila photoreceptors lacking milton, a kinesin-associated protein

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Identification and characterization of the Drosophila tau homolog.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431335

A comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathies

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22952452

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1002918

1 reference

2 August 2017

1 reference

2 August 2017

1 reference