Cellular pathophysiology of portal hypertension and prospects for management with gene therapy (Q34374972)

1 August 2017

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title

Cellular pathophysiology of portal hypertension and prospects for management with gene therapy (English)

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1 August 2017

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Rockey DC

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PubMed ID

11565144

1 August 2017

language of work or name

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1 August 2001

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1 August 2017

Clinics in liver disease

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1 August 2017

5

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1 August 2017

851-865

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1 August 2017

3

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Angiotensin II induces contraction and proliferation of human hepatic stellate cells

1 August 2017

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Arginine vasopressin induces contraction and stimulates growth of cultured human hepatic stellate cells.

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Foreword: prospects of liver cell transplantation and liver-directed gene therapy

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Regulation of sinusoidal perfusion: in vivo methodology and control by endothelins

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Transfer of genes to humans: early lessons and obstacles to success

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Gene therapy for liver disease

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

The endothelial nitric-oxide synthase-caveolin regulatory cycle

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Hepatic effects of endothelin. Receptor characterization and endothelin-induced signal transduction in hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

An endothelin receptor antagonist TAK-044 ameliorates carbon tetrachloride-induced acute liver injury and portal hypertension in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Increased hepatic endothelin-1 levels and endothelin receptor density in cirrhotic rats

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Dynamic activation of endothelial nitric oxide synthase by Hsp90.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

The endothelin-1 binding site in rat liver tissue: light- and electron-microscopic autoradiographic studies

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Endothelin-1 modulates intrahepatic resistance in a rat model of noncirrhotic portal hypertension.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Eicosanoid-mediated contractility of hepatic stellate cells

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Relationship between endothelin and thromboxane A2 in rat liver microcirculation

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Conceptual review of the hepatic vascular bed.

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: implications for caveolae localization

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B rec

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

NIDDK Workshop on AAV Vectors: Gene Transfer into Quiescent Cells

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Caveolin versus calmodulin. Counterbalancing allosteric modulators of endothelial nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Nitric oxide synthases: which, where, how, and why?

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Plasma endothelin immunoreactivity in liver disease and the hepatorenal syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Molecular control of nitric oxide synthases in the cardiovascular system

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Hepatic gene therapy using adeno-associated virus vectors

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Chronic blockade of endothelin receptors in cirrhotic rats: Hepatic and hemodynamic effects

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

The effect of endothelin and its antagonist Bosentan on hemodynamics and microvascular exchange in cirrhotic rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Oligomerization of endothelial nitric oxide synthase. Evidence for a dominant negative effect of truncation mutants

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

The cellular pathogenesis of portal hypertension: stellate cell contractility, endothelin, and nitric oxide

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Characterization of endothelin receptors mediating rat hepatic stellate cell contraction

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Inducible nitric oxide synthase in rat hepatic lipocytes and the effect of nitric oxide on lipocyte contractility

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Cellular localization of endothelin-1 and increased production in liver injury in the rat: potential for autocrine and paracrine effects on stellate cells

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

1 reference

7 January 2021

The nitric oxide synthase family of proteins

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Protecting research subjects--what must be done

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Regulation of endothelin-1 synthesis by endothelin-converting enzyme-1 during wound healing

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Gene therapy of hepatic diseases: prospects for the new millennium

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Regulation of endothelin-1 action on the perfused rat liver

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs.

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Structure and function of sinusoidal lining cells in the liver

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

The endothelin system. A new target for therapeutic intervention

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Immunocytochemical Detection of Desmin in Fat-Storing Cells (Ito Cells)

1 reference

https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Roles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombination

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension

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https://api.crossref.org/works/10.1016%2FS1089-3261%2805%2970195-1

7 January 2021

10.1016/S1089-3261(05)70195-1

Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

11565144