Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries. (Q34361517)

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9 February 2020

title

Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries (English)

1 reference

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9 February 2020

1 reference

5

1 reference

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9 February 2020

author name string

Jason T Lowe

1

1 reference

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9 February 2020

Maurice D Lee

2

1 reference

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9 February 2020

Lakshmi B Akella

3

1 reference

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9 February 2020

Emeline Davoine

4

1 reference

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9 February 2020

Landon Durak

6

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9 February 2020

Jeremy R Duvall

7

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9 February 2020

Baudouin Gerard

8

1 reference

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9 February 2020

Edward B Holson

9

1 reference

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9 February 2020

Adrien Joliton

10

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9 February 2020

Sarathy Kesavan

11

1 reference

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9 February 2020

Berenice C Lemercier

12

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9 February 2020

Haibo Liu

13

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9 February 2020

Jean-Charles Marié

14

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9 February 2020

Carol A Mulrooney

15

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9 February 2020

Giovanni Muncipinto

16

1 reference

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9 February 2020

Morgan Welzel-O'Shea

17

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9 February 2020

Laura M Panko

18

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9 February 2020

Ann Rowley

19

1 reference

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9 February 2020

Byung-Chul Suh

20

1 reference

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9 February 2020

Meryl Thomas

21

1 reference

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9 February 2020

Florence F Wagner

22

1 reference

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9 February 2020

Jingqiang Wei

23

1 reference

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9 February 2020

Michael A Foley

24

1 reference

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9 February 2020

Lisa A Marcaurelle

25

1 reference

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9 February 2020

language of work or name

English

0 references

publication date

10 August 2012

1 reference

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Journal of Organic Chemistry

9 February 2020

published in

1 reference

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9 February 2020

volume

77

1 reference

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9 February 2020

issue

17

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9 February 2020

page(s)

7187-7211

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Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties

9 February 2020

cites work

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Application of a sparse matrix design strategy to the synthesis of dos libraries

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Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

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Synthesis of a 35-member stereoisomer library of bistramide A: evaluation of effects on actin state, cell cycle and tumor cell growth

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Novel syntheses of azetidines and azetidinones.

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6 July 2018

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6 July 2018

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An approach to skeletal diversity using functional group pairing of multifunctional scaffolds

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6 July 2018

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

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Antibacterial natural products in medicinal chemistry--exodus or revival?

6 July 2018

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Total synthesis of a 28-member stereoisomer library of murisolins

6 July 2018

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Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery

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Medicinal chemical properties of successful central nervous system drugs

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Diversity-oriented synthesis: exploring the intersections between chemistry and biology

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Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors

6 July 2018

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Exploring new chemical space by stereocontrolled diversity-oriented synthesis

6 July 2018

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A library of spirooxindoles based on a stereoselective three-component coupling reaction.

6 July 2018

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The discovery and development of modified penicillin- and cephalosporin-derived beta-lactamase inhibitors

6 July 2018

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6 July 2018

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Beta-lactams in the new millennium. Part-I: monobactams and carbapenems

6 July 2018

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Fluorous mixture synthesis of stereoisomer libraries: total syntheses of (+)-murisolin and fifteen diastereoisomers

6 July 2018

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A planning strategy for diversity-oriented synthesis

6 July 2018

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Design of beta-lactams with mechanism based nonantibacterial activities

6 July 2018

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NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities

6 July 2018

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Synthesis and stereostructure-activity relationship of three asymmetric center pyrethroids: 2-methyl-3-phenylcyclopropylmethyl 3-phenoxybenzyl ether and cyanohydrin ester

6 July 2018

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Target-oriented and diversity-oriented organic synthesis in drug discovery

6 July 2018

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Synthetic strategies and medicinal properties of beta-lactams.

6 July 2018

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MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

6 July 2018

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P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels.

6 July 2018

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Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells

6 July 2018

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Oxetanes in drug discovery: structural and synthetic insights

6 July 2018

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Escape from flatland: increasing saturation as an approach to improving clinical success.

27 October 2018

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Copper(I)-catalyzed aryl bromides to form intermolecular and intramolecular carbon-oxygen bonds.

27 October 2018

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Large scale preparation of silicon-functionalized SynPhase Polystyrene lanterns for solid-phase synthesis

27 October 2018

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Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors

27 October 2018

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Spirocyclic oxetanes: synthesis and properties

27 October 2018

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Synthesis of all 16 stereoisomers of pinesaw fly sex pheromones--tools and tactics for solving problems in fluorous mixture synthesis.

27 October 2018

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Practical asymmetric preparation of azetidine-2-carboxylic acid.

27 October 2018

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Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates

27 October 2018

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Mild and efficient copper-catalyzed amination of aryl bromides with primary alkylamines.

27 October 2018

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Palladium-catalyzed intramolecular C-O bond formation

27 October 2018

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Preparation of the Reagent o-Nitrobenzenesulfonylhydrazide.

27 October 2018

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A concise enantioselective entry to the synthesis of deoxy-azasugars.

27 October 2018

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Drug discovery: A question of library design

27 October 2018

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Diversity-oriented synthesis of bicyclic and tricyclic alkaloids

9 December 2018

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Anionic, in situ generation of formaldehyde: a very useful and versatile tool in synthesis

9 December 2018

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12 December 2020

Efficient Nickel-Mediated Intramolecular Amination of Aryl Chlorides

1 reference

12 December 2020

Expanding the Azaspiro[3.3]heptane Family: Synthesis of Novel Highly Functionalized Building Blocks

1 reference

12 December 2020

Synthesis and Structural Analysis of a New Class of Azaspiro[3.3]heptanes as Building Blocks for Medicinal Chemistry

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12 December 2020

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

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12 December 2020

Synthesis of Azaspirocycles and their Evaluation in Drug Discovery

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Copper-catalyzed coupling of alkylamines and aryl iodides: an efficient system even in an air atmosphere

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12 December 2020

Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons

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12 December 2020

Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

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12 December 2020

Identifiers

DOI

10.1021/JO300974J

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22853001%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22853001%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

22853001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22853001%20AND%20SRC:MED&resulttype=core&format=json