Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis (Q34338564)

1 August 2017

Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis (English)

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1 August 2017

C Nogueira

1

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1 August 2017

K-H Kim

2

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1 August 2017

H Sung

3

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1 August 2017

K H T Paraiso

4

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1 August 2017

J-H Dannenberg

5

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1 August 2017

M Bosenberg

6

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1 August 2017

L Chin

7

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1 August 2017

M Kim

8

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1 August 2017

language of work or name

English

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publication date

16 August 2010

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1 August 2017

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1 August 2017

29

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6222-6232

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47

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https://scigraph.springernature.com/pub.10.1038/onc.2010.349

1 August 2017

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PTEN, more than the AKT pathway

6 July 2018

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Ubiquitination regulates PTEN nuclear import and tumor suppression

6 July 2018

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6 July 2018

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Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

6 July 2018

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TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN.

6 July 2018

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Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis

6 July 2018

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Use of human tissue to assess the oncogenic activity of melanoma-associated mutations

6 July 2018

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Role of epidermal growth factor receptor signaling in RAS-driven melanoma

6 July 2018

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Implication of the MAGI-1b/PTEN signalosome in stabilization of adherens junctions and suppression of invasiveness.

6 July 2018

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Deregulated Akt3 activity promotes development of malignant melanoma

6 July 2018

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Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma

6 July 2018

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Pten dose dictates cancer progression in the prostate

6 July 2018

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Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

6 July 2018

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Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

6 July 2018

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High frequency of BRAF mutations in nevi

6 July 2018

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Mutations of the BRAF gene in human cancer

6 July 2018

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6 July 2018

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Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice

6 July 2018

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Dual inactivation of RB and p53 pathways in RAS-induced melanomas

6 July 2018

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Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.

6 July 2018

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Essential role for oncogenic Ras in tumour maintenance

6 July 2018

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PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

6 July 2018

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

6 July 2018

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Pten is essential for embryonic development and tumour suppression

6 July 2018

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Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

6 July 2018

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Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.

6 July 2018

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

6 July 2018

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

6 July 2018

1 reference

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Complementation of hypopigmentation in p-mutant (pink-eyed dilution) mouse melanocytes by normal human P cDNA, and defective complementation by OCA2 mutant sequences

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2989338

Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer

6 July 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.349

Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.349

Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.349

Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.349

Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.349

Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.349

AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.349

Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2989338

High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2989338

Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61Kon an INK4a-Deficient Background

27 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.349

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.349

Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.349

Analysis of ras mutations in human melanocytic lesions: activation of the ras gene seems to be associated with the nodular type of human malignant melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.349

Methylation of PTEN as a prognostic factor in malignant melanoma of the skin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.349

Epigenetic silencing of the PTEN gene in melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.349

Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20711233

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Loss of PTEN promotes tumor development in malignant melanoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20711233

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2010.349

1 reference

Dimensions Publication ID

1 August 2017

0 references

1 reference

1 August 2017

1 reference