Structural genomics: opportunities and challenges (Q34318057)

1 August 2017

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title

Structural genomics: opportunities and challenges (English)

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1 August 2017

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Mittl PR

1

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PubMed ID

11470603

1 August 2017

Grütter MG

series ordinal

2

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1 August 2017

1 August 2001

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Current Opinion in Chemical Biology

1 August 2017

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1 August 2017

5

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1 August 2017

402-408

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1 August 2017

4

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Structural genomics: an overview

1 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

An overview of structural genomics.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Methodologies for target selection in structural genomics.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Target selection for structural genomics

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Estimating the number of protein folds and families from complete genome data

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Estimating the number of protein folds.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Establishing homologies in protein sequences

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Recognition of phylogenetic relationships from polypeptide chain fold similarities

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Expectations from structural genomics

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Selecting protein targets for structural genomics of Pyrobaculum aerophilum: validating automated fold assignment methods by using binary hypothesis testing

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Structure-based evaluation of sequence comparison and fold recognition alignment accuracy.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Improving the quality of twilight-zone alignments

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Protein fold recognition using sequence profiles and its application in structural genomics

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Fold recognition and accurate query-template alignment by a combination of PSI-BLAST and threading

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

An integrated approach to structural genomics.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Microbial genomics: from sequence to function

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Combining structural genomics and enzymology: completing the picture in metabolic pathways and enzyme active sites

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

The Molecular Biology Database Collection: an updated compilation of biological database resources

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

The COG database: new developments in phylogenetic classification of proteins from complete genomes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

CluSTr: a database of clusters of SWISS-PROT+TrEMBL proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

ProtoMap: automatic classification of protein sequences and hierarchy of protein families

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Shining a light on structural genomics.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Structural proteomics of an archaeon

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

The cysteine-rich protein A from Helicobacter pylori is a beta-lactamase

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Towards structural genomics for transmembrane proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Synchrotron crystallography

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Protein NMR spectroscopy in structural genomics

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Macromolecular electron microscopy in the era of structural genomics

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Protein production: feeding the crystallographers and NMR spectroscopists

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Structural proteomics: prospects for high throughput sample preparation

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

A human cDNA library for high-throughput protein expression screening

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

High-throughput protein expression of cDNA products as a tool in functional genomics

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

From genes to proteins: high-throughput expression and purification of the human proteome

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Protein expression strategies for identification of novel target proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

A generic protein purification method for protein complex characterization and proteome exploration

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Cell-free production and stable-isotope labeling of milligram quantities of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Cell-free expression and functional reconstitution of homo-oligomeric alpha7 nicotinic acetylcholine receptors into planar lipid bilayers

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Escherichia coli skp chaperone coexpression improves solubility and phage display of single-chain antibody fragments.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Rapid protein-folding assay using green fluorescent protein

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

A method for the purification and refolding of a recombinant form of the nontypeable Haemophilus influenzae P5 outer membrane protein fused to polyhistidine

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

A new protein folding screen: application to the ligand binding domains of a glutamate and kainate receptor and to lysozyme and carbonic anhydrase

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Chromatographic purification of the C(H)2 domain of the monoclonal antibody MAK33.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Design of highly stable functional GroEL minichaperones.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Design of high-throughput methods of protein production for structural biology

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Human prion proteins expressed in Escherichia coli and purified by high-affinity column refolding

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Approaches to functional genomics: potential of matrix-assisted laser desorption ionization--time of flight mass spectrometry combined with separation methods for the analysis of DNA in biological samples

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Protein crystallization by design: chymotrypsinogen without precipitants

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

High-throughput protein crystallization

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Structural genomics in North America.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Crystallization in cubo: general applicability to membrane proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Automation of X-ray crystallography

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Advances in multiple wavelength anomalous diffraction crystallography

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Novel approach to phasing proteins: derivatization by short cryo-soaking with halides

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Current state of automated crystallographic data analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Impact of transverse relaxation optimized spectroscopy (TROSY) on NMR as a technique in structural biology

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

TROSY and CRINEPT: NMR with large molecular and supramolecular structures in solution.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

[15N,1H]/[13C,1H]-TROSY for simultaneous detection of backbone 15N-1H, aromatic 13C-1H and side-chain 15N-1H2 correlations in large proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Determination of h2J(NN) and h1J(HN) coupling constants across Watson-Crick base pairs in the Antennapedia homeodomain-DNA complex using TROSY.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

The second decade--into the third millenium.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

High-resolution, >1 GHz NMR in unstable magnetic fields

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Structural genomics in Europe: slow start, strong finish?

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Structural genomics projects in Japan

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

1 reference

7 January 2021

A fully automatic evolutionary classification of protein folds: Dali Domain Dictionary version 3

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

SCOP: a structural classification of proteins database

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

A rapid classification protocol for the CATH Domain Database to support structural genomics

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Predicting protein function from structure: unique structural features of proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Recognition of spatial motifs in protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Fast prediction and visualization of protein binding pockets with PASS.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Rational design of potent sialidase-based inhibitors of influenza virus replication

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Structural genomics in the biotechnology sector

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

New roles for structure in biology and drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Crystal structure of YbaK protein from Haemophilus influenzae (HI1434) at 1.8 A resolution: functional implications

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Structure-based identification of a novel NTPase from Methanococcus jannaschii

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Structure of nicotinamide mononucleotide adenylyltransferase: a key enzyme in NAD(+) biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Structure-based assignment of the biochemical function of a hypothetical protein: a test case of structural genomics

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Electrostatic stress in catalysis: Structure and mechanism of the enzyme orotidine monophosphate decarboxylase

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Rapid fold and structure determination of the archaeal translation elongation factor 1beta from Methanobacterium thermoautotrophicum

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

Structure-based functional classification of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

A phylogenetic approach to target selection for structural genomics: solution structure of YciH

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

A test case for structure-based functional assignment: The 1.2 Å crystal structure of the yjgF gene product from Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

The structure of theyrdCgene product fromEscherichia colireveals a new fold and suggests a role in RNA binding

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900221-0

7 January 2021

10.1016/S1367-5931(00)00221-0

Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

11470603