CNGB3-achromatopsia clinical trial with CNTF: diminished rod pathway responses with no evidence of improvement in cone function (Q34312144)

1 August 2017

title

CNGB3-achromatopsia clinical trial with CNTF: diminished rod pathway responses with no evidence of improvement in cone function (English)

1 reference

1 August 2017

Wadih M Zein

1

1 reference

1 August 2017

Brett G Jeffrey

2

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1 August 2017

Henry E Wiley

3

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1 August 2017

Amy E Turriff

4

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1 August 2017

Santa J Tumminia

5

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1 August 2017

Weng Tao

6

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1 August 2017

Ronald A Bush

7

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1 August 2017

Dario Marangoni

8

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1 August 2017

Rong Wen

9

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1 August 2017

Lisa L Wei

10

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1 August 2017

Paul A Sieving

11

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1 August 2017

language of work or name

English

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publication date

9 September 2014

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Investigative Ophthalmology Visual Science

1 August 2017

published in

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1 August 2017

volume

55

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1 August 2017

issue

10

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1 August 2017

page(s)

6301-6308

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Retinal structure and function in achromatopsia: implications for gene therapy.

1 August 2017

cites work

1 reference

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6 July 2018

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Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia

6 July 2018

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6 July 2018

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6 July 2018

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Long-term and age-dependent restoration of visual function in a mouse model of CNGB3-associated achromatopsia following gene therapy

6 July 2018

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6 July 2018

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Early-onset, slow progression of cone photoreceptor dysfunction and degeneration in CNG channel subunit CNGB3 deficiency

6 July 2018

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6 July 2018

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Gene therapy rescues cone function in congenital achromatopsia

6 July 2018

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CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration

6 July 2018

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Gene therapy for red-green colour blindness in adult primates

6 July 2018

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Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping

6 July 2018

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Application of encapsulated cell technology for retinal degenerative diseases

6 July 2018

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Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17.

6 July 2018

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Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants

6 July 2018

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Sustained secretion of ciliary neurotrophic factor to the vitreous, using the encapsulated cell therapy-based NT-501 intraocular device.

6 July 2018

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CNGB3 mutations account for 50% of all cases with autosomal recessive achromatopsia

6 July 2018

1 reference

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Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1

6 July 2018

1 reference

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Subunit configuration of heteromeric cone cyclic nucleotide-gated channels

6 July 2018

1 reference

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Functionally Important Calmodulin-binding Sites in Both NH2- and COOH-terminal Regions of the Cone Photoreceptor Cyclic Nucleotide-gated Channel CNGB3 Subunit

6 July 2018

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Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191169

Subunit stoichiometry of the CNG channel of rod photoreceptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191169

Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191169

Cyclic nucleotide-gated ion channels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191169

Mutations in the CNGB3 gene encoding the beta-subunit of the cone photoreceptor cGMP-gated channel are responsible for achromatopsia (ACHM3) linked to chromosome 8q21.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191169

Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3.

6 July 2018

1 reference

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Structure and function of cyclic nucleotide-gated channels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191169

Beta wave of the scotopic (rod) electroretinogram as a measure of the activity of human on-bipolar cells

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191169

Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191169

Cholinergic neuronotrophic factors: intraocular distribution of trophic activity for ciliary neurons

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191169

High-resolution in vivo imaging in achromatopsia.

6 July 2018

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Comprehensive analysis of the achromatopsia genes CNGA3 and CNGB3 in progressive cone dystrophy

28 October 2018

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ISCEV Standard for full-field clinical electroretinography (2008 update).

28 October 2018

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Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa

28 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191169

Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: dose-dependent effects on ERG and retinal histology

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191169

Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191169

The human rod ERG: correlation with psychophysical responses in light and dark adaptation

28 October 2018

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12 December 2020

Cholinergic neuronotrophic factors: I. Survival, neurite outgrowth and choline acetyltransferase activity in monolayer cultures from chick embryo ciliary ganglia

1 reference

12 December 2020

Abnormal activation and inactivation mechanisms of rod transduction in patients with autosomal dominant retinitis pigmentosa and the pro-23-his mutation

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12 December 2020

Colour discrimination ellipses in patients with dominant optic atrophy

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12 December 2020

The H-R-R polychromatic plates. I. A. test for the detection, classification, and estimation of the degree of defective color vision

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12 December 2020

Regulation of rod phototransduction machinery by ciliary neurotrophic factor

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12 December 2020

Foveal development and nystagmus

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12 December 2020

Two-year intraocular delivery of ciliary neurotrophic factor by encapsulated cell technology implants in patients with chronic retinal degenerative diseases

1 reference

12 December 2020

Identifiers

DOI

10.1167/IOVS.14-14860

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1 August 2017

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1 August 2017

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