A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway (Q34311770)

1 August 2017

title

A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway (English)

1 reference

1 August 2017

Felipe A Court

5

0 references

Valentina Parra

object named as

Valentina Parra

4

0 references

Sergio Lavandero

object named as

Sergio Lavandero

9

0 references

Stanley J. Korsmeyer

8

object named as

Stanley J Korsmeyer

1 reference

1 August 2017

Sebastián Zamorano

1

1 reference

1 August 2017

Diego Rojas-Rivera

2

1 reference

1 August 2017

Fernanda Lisbona

3

1 reference

1 August 2017

Rosario Villegas

6

1 reference

1 August 2017

Emily H Cheng

7

1 reference

1 August 2017

Claudio Hetz

10

1 reference

1 August 2017

language of work or name

English

0 references

publication date

12 June 2012

1 reference

1 August 2017

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1 August 2017

volume

7

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1 August 2017

issue

6

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1 August 2017

page(s)

e37782

1 reference

Creative Commons Attribution 4.0 International

1 August 2017

copyright license

start time

12 June 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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6 July 2018

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TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis

6 July 2018

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A unified model of mammalian BCL-2 protein family interactions at the mitochondria.

6 July 2018

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The unfolded protein response: integrating stress signals through the stress sensor IRE1α

6 July 2018

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Modulating stress responses by the UPRosome: a matter of life and death

6 July 2018

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Axonal degeneration is mediated by the mitochondrial permeability transition pore.

6 July 2018

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BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program

6 July 2018

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Oligomerization of the mitochondrial protein voltage-dependent anion channel is coupled to the induction of apoptosis

6 July 2018

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Mitochondria and cell death: outer membrane permeabilization and beyond

6 July 2018

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Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells.

6 July 2018

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Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

6 July 2018

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Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

6 July 2018

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Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery

6 July 2018

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Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis

6 July 2018

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The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

6 July 2018

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BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha

6 July 2018

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Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death

6 July 2018

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Divergent effects of PERK and IRE1 signaling on cell viability

6 July 2018

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Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1.

6 July 2018

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The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family.

6 July 2018

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Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis

6 July 2018

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Cytochrome c: functions beyond respiration

6 July 2018

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Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore.

6 July 2018

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Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels

6 July 2018

1 reference

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The BCL-2 protein family: opposing activities that mediate cell death

6 July 2018

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ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage

6 July 2018

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ER stress triggers apoptosis by activating BH3-only protein Bim

6 July 2018

1 reference

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Role of the mitochondrial membrane permeability transition in cell death

6 July 2018

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6 July 2018

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Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Mitochondrial ceramide and the induction of apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Automatic and quantitative measurement of protein-protein colocalization in live cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Cell death: critical control points

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

The expression and regulation of Bcl-2-related ovarian killer (Bok) mRNA in the developing and adult rat testis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Perk is essential for translational regulation and cell survival during the unfolded protein response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373601

Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037782

Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0037782

A Bax/Bak-independent mechanism of cytochrome c release

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22719850

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22719850

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0037782

1 reference

1 August 2017

0 references

1 reference

1 August 2017

1 reference