Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease. (Q34310530)

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English	Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease.	scientific article

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26 December 2019

Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease (English)

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26 December 2019

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26 December 2019

author name string

K J H Robson

1

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26 December 2019

D J Lehmann

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26 December 2019

V L C Wimhurst

3

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26 December 2019

K J Livesey

4

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26 December 2019

M Combrinck

5

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26 December 2019

A T Merryweather-Clarke

6

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26 December 2019

D R Warden

7

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26 December 2019

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1 April 2004

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26 December 2019

Journal of Medical Genetics

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26 December 2019

41

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26 December 2019

4

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26 December 2019

261-265

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26 December 2019

Iron misregulation in the brain: a primary cause of neurodegenerative disorders

1 reference

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6 July 2018

Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease

1 reference

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6 July 2018

Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?

1 reference

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6 July 2018

Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue

1 reference

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6 July 2018

Is Alzheimer's disease a mitochondrial disorder?

1 reference

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6 July 2018

Alzheimer's disease and oxygen radicals: new insights

1 reference

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6 July 2018

No association between DCP1 genotype and late-onset Alzheimer disease.

1 reference

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6 July 2018

Iron and neurodegenerative disorders

1 reference

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6 July 2018

Vulnerability of select neuronal types to Alzheimer's disease.

1 reference

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6 July 2018

Geography of HFE C282Y and H63D mutations

1 reference

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6 July 2018

Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease

1 reference

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6 July 2018

Oxidative stress and Alzheimer disease

1 reference

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6 July 2018

Mild cognitive impairment: clinical characterization and outcome

1 reference

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6 July 2018

The significance of haemochromatosis gene mutations in the general population: implications for screening

1 reference

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6 July 2018

The effect of HFE mutations on serum ferritin and transferrin saturation in the Jersey population.

1 reference

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6 July 2018

Abnormal localization of iron regulatory protein in Alzheimer's disease.

1 reference

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6 July 2018

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

6 July 2018

Association of transferrin C2 allele with late-onset Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

6 July 2018

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

1 reference

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6 July 2018

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

6 July 2018

Human transferrin (Tf): a single mutation at codon 570 determines Tf C1 or Tf C2 variant.

1 reference

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6 July 2018

A 1.1-Mb transcript map of the hereditary hemochromatosis locus

1 reference

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6 July 2018

Global prevalence of putative haemochromatosis mutations

1 reference

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6 July 2018

Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

1 reference

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6 July 2018

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

1 reference

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6 July 2018

Relationship of iron to oligodendrocytes and myelination

1 reference

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6 July 2018

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

1 reference

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6 July 2018

Evidence of neuronal oxidative damage in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

6 July 2018

Lactotransferrin immunocytochemistry in Alzheimer and normal human brain.

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6 July 2018

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

1 reference

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6 July 2018

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

1 reference

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6 July 2018

Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain

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6 July 2018

A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains

1 reference

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6 July 2018

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

1 reference

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6 July 2018

pH and the recycling of transferrin during receptor-mediated endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

6 July 2018

Ferritin: isolation of aluminum-ferritin complex from brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

6 July 2018

Effects of transferrin genetic phenotypes on total iron-binding capacity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

6 July 2018

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

1 reference

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6 July 2018

Iron-enriched oligodendrocytes: A reexamination of their spatial distribution

1 reference

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6 July 2018

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

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6 July 2018

A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains.

1 reference

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6 July 2018

The identification and characterization of oxidized RNAs in Alzheimer's disease.

1 reference

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28 October 2018

Immunocytochemical evidence that amyloid beta (1-42) impairs endogenous antioxidant systems in vivo

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28 October 2018

Association between the HFE mutations and unsuccessful ageing: a study in Alzheimer's disease patients from Northern Italy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Transferrin C2 allele, haemochromatosis gene mutations, and risk for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Transferrin gene polymorphism in Alzheimer's disease and dementia with Lewy bodies in humans.

1 reference

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28 October 2018

Using meta-analysis to explain the diversity of results in genetic studies of late-onset Alzheimer's disease and to identify high-risk subgroups.

1 reference

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28 October 2018

Oxidative damage is the earliest event in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

The hemochromatosis gene affects the age of onset of sporadic Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer's diseased brains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Apolipoprotein E genotype and progression of Alzheimer's disease: the Rotterdam Study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Increased nuclear DNA oxidation in the brain in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Transferrin C2, metal binding and Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

4-hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Cellular management of iron in the brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Increased frequency of the transferrin C2 subtype in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1735734

28 October 2018

Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation.

1 reference

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28 October 2018

A population-based study of the effect of the HFE C282Y and H63D mutations on iron metabolism

1 reference

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28 October 2018

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

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28 October 2018

Prevalence and penetrance of HFE mutations in 4865 unselected primary care patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/15060098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of the H63D mutation in the hemochromatosis gene with the apolipoprotein E epsilon 4 allele modulates age at onset of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15060098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphism in intron 4 of HFE does not compromise haemochromatosis mutation results. The European Haemochromatosis Consortium

1 reference

https://pubmed.ncbi.nlm.nih.gov/15060098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-haem iron histochemistry of the normal and Alzheimer's disease hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15060098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/15060098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Are hereditary hemochromatosis mutations involved in Alzheimer disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15060098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transferrin C2 as an enhancer of cyto- and genotoxic damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/15060098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HLA class I, II & III genes in confirmed late-onset Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15060098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E genotyping by one-stage PCR

1 reference

https://pubmed.ncbi.nlm.nih.gov/15060098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence against the involvement of reactive oxygen species in the pathogenesis of neuronal death in down's syndrome and Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15060098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1136/JMG.2003.015552

1 reference

Europe PubMed Central

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26 December 2019

1 reference

Europe PubMed Central

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26 December 2019

1 reference

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26 December 2019

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