Iron misregulation in the brain: a primary cause of neurodegenerative disorders (Q35172307)

6 August 2017

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title

Iron misregulation in the brain: a primary cause of neurodegenerative disorders (English)

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6 August 2017

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Ya Ke

1

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PubMed ID

12849213

6 August 2017

Zhong Ming Qian

series ordinal

2

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6 August 2017

1 April 2003

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6 August 2017

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6 August 2017

2

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6 August 2017

246-253

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6 August 2017

4

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Disorders of iron metabolism

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Iron homeostasis: insights from genetics and animal models

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Clinical Consequences of New Insights in the Pathophysiology of Disorders of Iron and Heme Metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Genetic disorders affecting proteins of iron metabolism: clinical implications

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Recent advances in disorders of iron metabolism: mutations, mechanisms and modifiers

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Systemic iron metabolism: a review and implications for brain iron metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Iron and neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

The iron metabolism of neoplastic cells: alterations that facilitate proliferation?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Domain homologues of dopamine beta-hydroxylase and ferric reductase: roles for iron metabolism in neurodegenerative disorders?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Brain iron transport and neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

1 reference

7 January 2021

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

The ferritins: molecular properties, iron storage function and cellular regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Early embryonic lethality of H ferritin gene deletion in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Hallervorden-Spatz Syndrome and Brain Iron Metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Hallervorden-Spatz disease: clinical and MRI study of 11 cases diagnosed in life

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Hallervorden-Spatz syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Cranial MRI changes may precede symptoms in Hallervorden-Spatz syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Hallervorden-Spatz disease: cysteine accumulation and cysteine dioxygenase deficiency in the globus pallidus

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Plasma cysteine and sulphate levels in patients with motor neurone, Parkinson's and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

HARP syndrome is allelic with pantothenate kinase-associated neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Aceruloplasminemia: molecular characterization of this disorder of iron metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Iron metabolism in eukaryotes: Mars and Venus at it again

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Hereditary caeruloplasmin deficiency: clinicopathological study of a patient

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Hereditary deficiency of ferroxidase (aka caeruloplasmin)

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Characterization of a nonsense mutation in the ceruloplasmin gene resulting in diabetes and neurodegenerative disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Estimation of the gene frequency of aceruloplasminemia in Japan

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Biochemical analysis of a missense mutation in aceruloplasminemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

1 reference

7 January 2021

Role of ceruloplasmin and ascorbate in cellular iron release

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

The sky blue protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

The physiopathological significance of ceruloplasmin. A possible therapeutic approach.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Hepatic iron overload in aceruloplasminaemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Ceruloplasmin metabolism and function

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Role of ceruloplasmin in cellular iron uptake

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Ceruloplasmin promotes iron uptake rather than release in BT325 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Effects of ferroxidase activity and species on ceruloplasmin mediated iron uptake by BT325 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Ceruloplasmin gene expression in the murine central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Expression of the ceruloplasmin gene in the human retina and brain: implications for a pathogenic model in aceruloplasminemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Rethinking the role of ceruloplasmin in brain iron metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

CSF abnormalities in patients with aceruloplasminemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Increased oxysterols associated with iron accumulation in the brains and visceral organs of acaeruloplasminaemia patients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Increased lipid peroxidation in the brains of aceruloplasminemia patients

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Use of desferrioxamine in the treatment of aceruloplasminemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Regulating the fate of mRNA: the control of cellular iron metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Demonstration and characterization of the iron regulatory protein in human brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Iron regulatory proteins in pathobiology.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Iron regulatory proteins and the molecular control of mammalian iron metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

An oxidative stress-mediated positive-feedback iron uptake loop in neuronal cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease cases

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Pumping iron in the '90s

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Serum levels of the iron binding protein p97 are elevated in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Melanotransferrin is produced by senile plaque-associated reactive microglia in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Serum melanotransferrin, p97 as a biochemical marker of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

p97 as a biomarker for Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

1 reference

7 January 2021

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Iron transport across biologic membranes

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Reduced ferroxidase activity in the cerebrospinal fluid from patients with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Brain iron pathways and their relevance to Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Stabilization of iron regulatory protein 2, IRP2, by aluminum

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Heme oxygenase-1: role in brain aging and neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Aceruloplasminemia: new clinical, pathophysiological and therapeutic insights

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Therapeutic potential in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

An iron-regulated ferric reductase associated with the absorption of dietary iron

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Distribution of ferroportin1 protein in different regions of developing rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

Mechanisms of iron accumulation in hereditary hemochromatosis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2803%2900353-3

7 January 2021

10.1016/S1474-4422(03)00353-3

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12849213