Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression (Q34300719)

1 August 2017

Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression (English)

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1 August 2017

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3

John Heymach

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1 August 2017

Keyi Zhu

1

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1 August 2017

Waikin Chan

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2

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1 August 2017

Miles Wilkinson

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4

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1 August 2017

David J McConkey

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5

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1 August 2017

language of work or name

English

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publication date

24 February 2009

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1 August 2017

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1 August 2017

69

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5

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1 August 2017

1836-1843

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describes a project that uses

1 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4188393/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway

6 July 2018

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Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain

6 July 2018

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6 July 2018

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6 July 2018

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Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

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PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway

6 July 2018

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ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

6 July 2018

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Bortezomib abolishes tumor necrosis factor-related apoptosis-inducing ligand resistance via a p21-dependent mechanism in human bladder and prostate cancer cells

6 July 2018

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HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.

6 July 2018

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Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

6 July 2018

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Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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The proteasome inhibitor bortezomib stabilizes a novel active form of p53 in human LNCaP-Pro5 prostate cancer cells

6 July 2018

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6 July 2018

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Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

6 July 2018

1 reference

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Signal transduction to hypoxia-inducible factor 1

6 July 2018

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6 July 2018

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6 July 2018

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HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome.

28 October 2018

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The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia.

28 October 2018

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Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts

28 October 2018

1 reference

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Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19244104

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-08-4103

1 reference

1 August 2017

1 reference

1 August 2017

1 reference