LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson disease (Q34299954)

1 August 2017

LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson disease (English)

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1 August 2017

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Matthew J Barrett

2

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Rachel Saunders-Pullman

1

object named as

Rachel Saunders-Pullman

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1 August 2017

8

Deborah Raymond

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1 August 2017

9

Laurie J Ozelius

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1 August 2017

10

Susan B Bressman

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1 August 2017

Kaili M Stanley

3

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1 August 2017

Marta San Luciano

4

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1 August 2017

Vicki Shanker

5

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1 August 2017

Lawrence Severt

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1 August 2017

Ann Hunt

7

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1 August 2017

language of work or name

English

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publication date

1 November 2010

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1 August 2017

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1 August 2017

25

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1 August 2017

2536-2541

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1 August 2017

15

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LRRK2 and Parkinson disease

1 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

The biology and pathology of the familial Parkinson's disease protein LRRK2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Parkinson's disease and cancer risk: a systematic review and meta-analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Family history of melanoma and Parkinson disease risk

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

New biochemical approaches towards understanding the Parkinson's disease-associated kinase, LRRK2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Are Parkinson disease patients protected from some but not all cancers?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Prospective case-control study of nonfatal cancer preceding the diagnosis of Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Apoptotic mechanisms in mutant LRRK2-mediated cell death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Patterns of somatic mutation in human cancer genomes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Kinase activity of mutant LRRK2 mediates neuronal toxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Biochemical and pathological characterization of Lrrk2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2978749

Autosomal dominant parkinsonism associated with variable synuclein and tau pathology.

6 July 2018

1 reference

LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

21 January 2018

1 reference

The leucine rich repeat kinase 2 (LRRK2) G2019S substitution mutation. Association with Parkinson disease, malignant melanoma and prevalence in ethnic groups in Israel.

21 January 2018

1 reference

Treatment with levodopa and risk for malignant melanoma

21 January 2018

1 reference

Frequency of LRRK2 mutations in early- and late-onset Parkinson disease.

21 January 2018

1 reference

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.

21 January 2018

1 reference

Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation

21 January 2018

1 reference

Malignant Melanoma and Other Types of Cancer Preceding Parkinson Disease

21 January 2018

1 reference

Are Parkinson disease patients protected from some but not all cancers?

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20818610

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/MDS.23314

1 reference

1 August 2017

1 reference

1 August 2017

1 reference