Treatment of Type 1 Diabetes With Anti-CD3 Monoclonal Antibody: Induction of Immune Regulation? (Q34275874)

1 August 2017

Treatment of Type 1 diabetes with anti-CD3 monoclonal antibody: induction of immune regulation? (English)

1 reference

https://api.crossref.org/works/10.1385/IR:28:2:141

1 August 2017

Treatment of Type 1 Diabetes With Anti-CD3 Monoclonal Antibody: Induction of Immune Regulation? (English)

1 reference

31 March 2024

0 references

1 reference

1 reference

1 reference

https://api.crossref.org/works/10.1385/IR:28:2:141

31 March 2024

1

Kevan C Herold

1 reference

1 August 2017

Lesley Taylor

2

1 reference

1 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14610290

31 March 2024

publication date

1 January 2003

1 reference

full work available at URL

1 August 2017

http://www.springerlink.com/index/pdf/10.1385/IR:28:2:141

1 reference

https://api.crossref.org/works/10.1385/IR:28:2:141

31 March 2024

1 reference

1 August 2017

28

1 reference

1 August 2017

2

1 reference

1 August 2017

141-150

1 reference

https://scigraph.springernature.com/pub.10.1385/ir:28:2:141

1 August 2017

0 references

cites work

T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice

1 reference

12 December 2020

Mechanism underlying counterregulation of autoimmune diabetes by IL-4.

1 reference

12 December 2020

The paradoxical effects of interleukin 10 in the immunoregulation of autoimmune diabetes

1 reference

12 December 2020

Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes.

1 reference

12 December 2020

TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.

1 reference

12 December 2020

In vivo use of OKT3: main issues for the monitoring of treated patients

1 reference

12 December 2020

Non-Fc receptor-binding humanized anti-CD3 antibodies induce apoptosis of activated human T cells

1 reference

12 December 2020

Phase I trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3gamma1(Ala-Ala) in the treatment of acute renal allograft rejection

1 reference

12 December 2020

Immunosuppression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus

1 reference

12 December 2020

HuM291, a humanized anti-CD3 antibody, is immunosuppressive to T cells while exhibiting reduced mitogenicity in vitro

1 reference

12 December 2020

T helper cell subsets in insulin-dependent diabetes

1 reference

12 December 2020

T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs

1 reference

12 December 2020

Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes

1 reference

12 December 2020

A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice

1 reference

12 December 2020

Anti-CD3 F(ab')2 fragments are immunosuppressive in vivo without evoking either the strong humoral response or morbidity associated with whole mAb

1 reference

12 December 2020

A humanized non-FcR-binding anti-CD3 antibody, visilizumab, for treatment of steroid-refractory acute graft-versus-host disease

1 reference

12 December 2020

The anti-CD3-induced syndrome: a consequence of massive in vivo cell activation

1 reference

12 December 2020

Advantages of F(ab')2 fragments of anti-CD3 monoclonal antibody as compared to whole antibody as immunosuppressive agents in mice

1 reference

12 December 2020

Humanized OKT3 antibodies: successful transfer of immune modulating properties and idiotype expression

1 reference

12 December 2020

Interleukin-10 and the interleukin-10 receptor

1 reference

12 December 2020

Activated self-MHC-reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells

1 reference

12 December 2020

Effects of Cyclosporine Immunosuppression in Insulin-Dependent Diabetes Mellitus of Recent Onset

1 reference

12 December 2020

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

1 reference

12 December 2020

The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties

1 reference

12 December 2020

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

1 reference

12 December 2020

B-cell function and blood glucose control in insulin dependent diabetics within the first month of insulin treatment

1 reference

12 December 2020

CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer

1 reference

12 December 2020

Factors associated with early remission of type I diabetes in children treated with cyclosporine

1 reference

12 December 2020

Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. A gene therapy model for autoimmune diabetes

1 reference

12 December 2020

Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse

1 reference

12 December 2020

IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells.

1 reference

12 December 2020

Interleukin 10 is a growth factor for a population of regulatory T cells

1 reference

12 December 2020

IFN-gamma production is specifically regulated by IL-10 in mice made tolerant with anti-CD40 ligand antibody and intact active bone

1 reference

12 December 2020

OKT3-induced cytokine-release syndrome: prevention effect of anti-tumor necrosis factor monoclonal antibody.

1 reference

12 December 2020

Prevention of autoimmune diabetes with nonactivating anti-CD3 monoclonal antibody

1 reference

12 December 2020

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice

1 reference

12 December 2020

Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy

1 reference

12 December 2020

In vitro characterization of five humanized OKT3 effector function variant antibodies.

1 reference

12 December 2020

Humoral immune response against OKT3

1 reference

12 December 2020

Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse.

1 reference

12 December 2020

Type 1 T regulatory cells.

1 reference

12 December 2020

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

1 reference

12 December 2020

CD3 antibody-induced IL-10 in renal allograft recipients: an in vivo and in vitro analysis

1 reference

12 December 2020

Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin

1 reference

12 December 2020

HuM291(Nuvion), a humanized Fc receptor-nonbinding antibody against CD3, anergizes peripheral blood T cells as partial agonist of the T cell receptor

1 reference

12 December 2020

CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice

1 reference

12 December 2020

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

1 reference

12 December 2020

Localized interleukin-10 gene transfer induces apoptosis of alloreactive T cells via FAS/FASL pathway, improves function, and prolongs survival of cardiac allograft

1 reference

12 December 2020

Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets

1 reference

12 December 2020

Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice

1 reference

12 December 2020

Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology

1 reference

12 December 2020

Multiple immuno-regulatory defects in type-1 diabetes

1 reference

12 December 2020

Effects of in vivo administration of anti-CD3 monoclonal antibody on T cell function in mice. II. In vivo activation of T cells

1 reference

12 December 2020

Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells.

1 reference

12 December 2020

A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1 reference

12 December 2020

A new type of CD4+ suppressor T cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice

1 reference

12 December 2020

Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).

1 reference

12 December 2020

Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats

1 reference

12 December 2020

Thymic positive selection and peripheral activation of islet antigen-specific T cells: separation of two diabetogenic steps by an I-A(g7) class II MHC beta-chain mutant

1 reference

12 December 2020

Identifiers

DOI

10.1385/IR:28:2:141

1 reference

Dimensions Publication ID

1 August 2017

0 references

1 reference