Design of β-amyloid aggregation inhibitors from a predicted structural motif (Q34261600)

1 August 2017

Design of β-amyloid aggregation inhibitors from a predicted structural motif (English)

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1 August 2017

Paul A Novick

1

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1 August 2017

Dahabada H Lopes

2

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1 August 2017

Kim M Branson

3

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1 August 2017

Alexandra Esteras-Chopo

4

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1 August 2017

Isabella A Graef

5

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1 August 2017

Gal Bitan

6

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1 August 2017

Vijay S Pande

7

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1 August 2017

language of work or name

English

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publication date

15 March 2012

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Journal of Medicinal Chemistry

1 August 2017

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1 August 2017

55

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1 August 2017

7

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1 August 2017

3002-3010

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describes a project that uses

1 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3766731/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Rationally designed turn promoting mutation in the amyloid-β peptide sequence stabilizes oligomers in solution

1 reference

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Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils

6 July 2018

1 reference

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Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity

6 July 2018

1 reference

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Structure-neurotoxicity relationships of amyloid beta-protein oligomers

6 July 2018

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Photo-induced cross-linking of unmodified proteins (PICUP) applied to amyloidogenic peptides.

6 July 2018

1 reference

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Simulating oligomerization at experimental concentrations and long timescales: A Markov state model approach

6 July 2018

1 reference

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Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers

6 July 2018

1 reference

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

6 July 2018

1 reference

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Physicochemical characteristics of soluble oligomeric Abeta and their pathologic role in Alzheimer's disease.

6 July 2018

1 reference

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Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease

6 July 2018

1 reference

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In silico study of amyloid beta-protein folding and oligomerization

6 July 2018

1 reference

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Amyloid beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766731

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766731

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766731

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

6 July 2018

1 reference

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Alzheimer's disease: a re-examination of the amyloid hypothesis

6 July 2018

1 reference

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766731

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766731

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766731

Alzheimer's disease: the amyloid cascade hypothesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766731

Surprising toxicity and assembly behaviour of amyloid β-protein oxidized to sulfone.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766731

High-molecular-weight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766731

A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.

28 October 2018

1 reference

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Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766731

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766731

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766731

Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22420626

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM201332P

1 reference

1 August 2017

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1 August 2017

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