Different immunological mechanisms govern protection from experimental stroke in young and older mice with recombinant TCR ligand therapy (Q34242088)

31 July 2017

title

Different immunological mechanisms govern protection from experimental stroke in young and older mice with recombinant TCR ligand therapy (English)

1 reference

31 July 2017

1 reference

5

Halina Offner

1 reference

31 July 2017

Abby L Dotson

1

1 reference

31 July 2017

Wenbin Zhu

series ordinal

2

1 reference

31 July 2017

Nicole Libal

series ordinal

3

1 reference

31 July 2017

Nabil J Alkayed

series ordinal

4

1 reference

31 July 2017

language of work or name

1 reference

25 September 2014

1 reference

Frontiers in Cellular Neuroscience

31 July 2017

published in

1 reference

31 July 2017

volume

8

1 reference

31 July 2017

page(s)

284

1 reference

Recombinant T cell receptor ligand treatment improves neurological outcome in the presence of tissue plasminogen activator in experimental ischemic stroke

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Novel humanized recombinant T cell receptor ligands protect the female brain after experimental stroke

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Treatment of experimental stroke with IL-10-producing B-cells reduces infarct size and peripheral and CNS inflammation in wild-type B-cell-sufficient mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Phenotypic changes in immune cell subsets reflect increased infarct volume in male vs. female mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

A novel HLA-DRα1-MOG-35-55 construct treats experimental stroke

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Leukocyte infiltration in experimental stroke

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Forecasting the future of stroke in the United States: a policy statement from the American Heart Association and American Stroke Association

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Adoptive regulatory T-cell therapy protects against cerebral ischemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Pivotal roles of monocytes/macrophages in stroke

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Interleukin-17 in post-stroke neurodegeneration

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Age and the metabolic syndrome as risk factors for ischemic stroke: improving preclinical models of ischemic stroke

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

A transient decrease in spleen size following stroke corresponds to splenocyte release into systemic circulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Regulatory T cells accumulate and proliferate in the ischemic hemisphere for up to 30 days after MCAO.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Distinctive effects of T cell subsets in neuronal injury induced by cocultured splenocytes in vitro and by in vivo stroke in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Regulation of Antigen-Experienced T Cells: Lessons from the Quintessential Memory Marker CD44.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Homeostasis and function of regulatory T cells in aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Recombinant T cell receptor ligands improve outcome after experimental cerebral ischemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Therapy with recombinant T-cell receptor ligand reduces infarct size and infiltrating inflammatory cells in brain after middle cerebral artery occlusion in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Expansion of regulatory T cells in aged mice following influenza infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Middle cerebral artery occlusion model in rodents: methods and potential pitfalls

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Multifaceted regulation of T cells by CD44.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

RTL therapy for multiple sclerosis: a Phase I clinical study.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

CD44 and its role in inflammation and inflammatory diseases.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Recombinant T cell receptor ligand treats experimental stroke

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Tumor necrosis factor and stroke: role of the blood-brain barrier

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Inflammation in stroke and focal cerebral ischemia.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

1,026 experimental treatments in acute stroke

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

The influence of age on T cell generation and TCR diversity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174768

Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury.

6 July 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

Monomeric recombinant TCR ligand reduces relapse rate and severity of experimental autoimmune encephalomyelitis in SJL/J mice through cytokine switch

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

IL-17 and IFN-gamma mRNA expression is increased in the brain and systemically after permanent middle cerebral artery occlusion in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

Regulatory T cells protect the brain after stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-alphabetaTCR interaction and become IL-10-producing active regulatory cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

Regulatory T cells in ischemic stroke: helpful or hazardous?

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

Recombinant TCR ligand induces early TCR signaling and a unique pattern of downstream activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

CD8 regulatory T cells: what's old is now new.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

The paradox role of regulatory T cells in ischemic stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

Role of T lymphocytes and interferon-gamma in ischemic stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFNCEL.2014.00284

Early T-cell activation in elderly humans

21 January 2018

1 reference

12 December 2020

Flow cytometric analysis of inflammatory cells in ischemic rat brain

1 reference

12 December 2020

Human leukocyte antigen-DRB1*1502 (DR2Dw12) transgene reduces incidence and severity of arthritis in mice

1 reference

12 December 2020

Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cells

1 reference

12 December 2020

Design, engineering and production of functional single-chain T cell receptor ligands

1 reference

12 December 2020

Age-associated changes in interferon-gamma and interleukin-4 secretion by purified human CD4+ and CD8+ T cells

1 reference

12 December 2020

Con: Regulatory T cells are protective in ischemic stroke

1 reference

12 December 2020

Increased cytokine production in mononuclear cells of healthy elderly people

1 reference

12 December 2020

The increase of IFN-gamma production through aging correlates with the expanded CD8(+high)CD28(-)CD57(+) subpopulation

1 reference

12 December 2020

High accumulation of T regulatory cells prevents the activation of immune responses in aged animals

1 reference

12 December 2020

Experimental stroke induces massive, rapid activation of the peripheral immune system

1 reference

12 December 2020

Quantitative and qualitative changes in CD44 and MEL-14 expression by T cells in C57BL/6 mice during aging

1 reference

12 December 2020

Identifiers

DOI

10.3389/FNCEL.2014.00284

1 reference

31 July 2017

1 reference

31 July 2017

1 reference