Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins (Q34241138)

31 July 2017

Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins (English)

1 reference

31 July 2017

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25062688%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

James Shorter

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25062688%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Meredith E Jackrel

series ordinal

1

1 reference

PubMed ID

25062688

31 July 2017

James Shorter

series ordinal

2

1 reference

31 July 2017

25 July 2014

1 reference

Disease Models & Mechanisms

31 July 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25062688%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25062688%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

1175-1184

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25062688%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25062688%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

13 June 2020

copyright license

start time

18 May 2021

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4174528/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events

6 July 2018

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Hsp104 drives "protein-only" positive selection of Sup35 prion strains encoding strong [PSI(+)].

6 July 2018

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6 July 2018

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A yeast functional screen predicts new candidate ALS disease genes

6 July 2018

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The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system

6 July 2018

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An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions

6 July 2018

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Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Hsp104: a weapon to combat diverse neurodegenerative disorders.

6 July 2018

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6 July 2018

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Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity

6 July 2018

1 reference

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Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities

6 July 2018

1 reference

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Structure and mechanism of the Hsp90 molecular chaperone machinery

6 July 2018

1 reference

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Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein

6 July 2018

1 reference

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Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174528

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

6 July 2018

1 reference

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Protein folding and misfolding

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174528

Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP.

6 July 2018

1 reference

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

6 July 2018

1 reference

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Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins

6 July 2018

1 reference

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

6 July 2018

1 reference

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Protein disaggregation mediated by heat-shock protein Hsp104.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174528

HSP104 required for induced thermotolerance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174528

Hsp104 is a highly conserved protein with two essential nucleotide-binding sites.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174528

The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174528

Human and yeast Hsp110 chaperones exhibit functional differences.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174528

A chaperone pathway in protein disaggregation. Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174528

Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174528

Yeast cells provide insight into alpha-synuclein biology and pathobiology

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4174528

Alpha-synuclein and Parkinson's disease

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25062688

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1242/DMM.016113

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25062688%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25062688%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25062688%20AND%20SRC:MED&resulttype=core&format=json