A mechanistic insight into 3,4-methylenedioxymethamphetamine ("ecstasy")-mediated hepatotoxicity. (Q34239110)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22151050%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

A mechanistic insight into 3,4-methylenedioxymethamphetamine ("ecstasy")-mediated hepatotoxicity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22151050%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

Majorie B M van Duursen

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22151050%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

3

Martin van den Berg

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22151050%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author name string

Irene Antolino-Lobo

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22151050%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Jan Meulenbelt

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22151050%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

publication date

13 December 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22151050%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22151050%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

volume

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22151050%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22151050%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

193-205

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22151050%20AND%20SRC:MED&resulttype=core&format=json

Are there sex differences associated with the effects of ecstasy/3,4-methylenedioxymethamphetamine (MDMA)?

18 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Ecstasy: a common cause of severe acute hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Methylenedioxymethamphetamine ('Ecstasy')-induced immunosuppression: a cause for concern?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Tumour necrosis factor alpha suppression by MDMA is mediated by peripheral heteromeric nicotinic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Neurotoxicity mechanisms of thioether ecstasy metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('Ecstasy') cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Role of metabolites in MDMA (ecstasy)-induced nephrotoxicity: an in vitro study using rat and human renal proximal tubular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Mechanisms underlying the hepatotoxic effects of ecstasy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

The toxicity of N-methyl-alpha-methyldopamine to freshly isolated rat hepatocytes is prevented by ascorbic acid and N-acetylcysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Metabolism is required for the expression of ecstasy-induced cardiotoxicity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclc-knockout mice, providing a model for hepatic cirrhosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Altered states: the clinical effects of Ecstasy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Methylenedioxymethamphetamine suppresses production of the proinflammatory cytokine tumor necrosis factor-alpha independent of a beta-adrenoceptor-mediated increase in interleukin-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

The role of endogenous and exogenous ligands for the peroxisome proliferator-activated receptor alpha (PPAR-alpha) in the regulation of inflammation in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

MDMA (ecstasy) pharmacokinetics in a CYP2D6 poor metaboliser and in nine CYP2D6 extensive metabolisers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Clinical pharmacokinetics of amfetamine and related substances: monitoring in conventional and non-conventional matrices

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Non-linear pharmacokinetics of MDMA ('ecstasy') in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Peroxisome proliferator-activated receptors in inflammation control

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

The PPARalpha-leukotriene B4 pathway to inflammation control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Synthesis, in vitro formation, and behavioural effects of glutathione regioisomers of alpha-methyldopamine with relevance to MDA and MDMA (ecstasy).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Ecstasy: are animal data consistent between species and can they translate to humans?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Acute liver damage and ecstasy ingestion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Repeated doses administration of MDMA in humans: pharmacological effects and pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Microbial Infections, Immunomodulation, and Drugs of Abuse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Tissue concentrations of MDMA and its metabolite MDA in three fatal cases of overdose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Biologic and pharmacologic regulation of mammalian glutathione synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Protective effect of sulforaphane against cisplatin-induced mitochondrial alterations and impairment in the activity of NAD(P)H: quinone oxidoreductase 1 and γ glutamyl cysteine ligase: studies in mitochondria isolated from rat kidney and in LLC-PK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Fatal interaction between ritonavir and MDMA

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Mechanism-based inactivation of CYP2D6 by methylenedioxymethamphetamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Mechanisms of drug-induced liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Selective modulation of immune function resulting from in vitro exposure to methylenedioxymethamphetamine (Ecstasy).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Inducers of gamma-glutamylcysteine synthetase and their effects on glutathione synthetase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Review article: mechanisms and management of hepatotoxicity in ecstasy (MDMA) and amphetamine intoxications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Serotonergic neurotoxic metabolites of ecstasy identified in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Molecular mechanism of nrf2 activation by oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Coordinate regulation of human drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Substrates of human hepatic cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Enzymatic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy)methamphetamine by rat brain microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Regulation of glutathione synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

The role of human hepatic cytochrome P450 isozymes in the metabolism of racemic 3,4-methylenedioxy-methamphetamine and its enantiomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Synthesis and cytotoxic profile of 3,4-methylenedioxymethamphetamine ("ecstasy") and its metabolites on undifferentiated PC12 cells: A putative structure-toxicity relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Lead stimulates intercellular signalling between hepatocytes and Kupffer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

The role of metabolism in 3,4-(+)-methylenedioxyamphetamine and 3,4-(+)-methylenedioxymethamphetamine (ecstasy) toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Biological reactivity of polyphenolic-glutathione conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

The role of glutathione-S-transferase polymorphisms on clinical outcome of ALI/ARDS patient treated with N-acetylcysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Nuclear receptor-mediated transcriptional regulation in Phase I, II, and III xenobiotic metabolizing systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

The consequences of 3,4-methylenedioxymethamphetamine induced CYP2D6 inhibition in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Paroxetine inhibits acute effects of 3,4-methylenedioxymethamphetamine on the immune system in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Immunomodulating activity of MDMA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Serotonergic neurotoxic thioether metabolites of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"): synthesis, isolation, and characterization of diastereoisomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Determination of MDMA and its metabolites in blood and urine by gas chromatography-mass spectrometry and analysis of enantiomers by capillary electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Chronic exposure to ethanol exacerbates MDMA-induced hyperthermia and exposes liver to severe MDMA-induced toxicity in CD1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

PPARalpha activation abolishes LDL-stimulated IL-8 production via AP-1 deactivation in human aortic smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Evaluation of medicinal plant hepatotoxicity in co-cultures of hepatocytes and monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

A bitter pill. Overview of ecstasy (MDMA, MDA) related fatalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

The effect of Ecstasy on memory is moderated by a functional polymorphism in the cathechol-O-methyltransferase (COMT) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Contribution of cytochrome P450 2D6 to 3,4-methylenedioxymethamphetamine disposition in humans: use of paroxetine as a metabolic inhibitor probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

3,4-Dihydroxymethamphetamine (HHMA). A major in vivo 3,4-methylenedioxymethamphetamine (MDMA) metabolite in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Tissue-specific effects of fenthion on glutathione metabolism modulated by NAC and BSO in Oreochromis niloticus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

4-Hydroxy-3-methoxymethamphetamine glucuronide as a phase II metabolite of 3,4-methylenedioxymethamphetamine: enzyme-assisted synthesis and involvement of human hepatic uridine 5'-diphosphate-glucuronosyltransferase 2B15 in the glucuronidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Metabolic drug interactions with newer antipsychotics: a comparative review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Metabolic drug interactions with new psychotropic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Kinetics of the time-dependent inactivation of CYP2D6 in cryopreserved human hepatocytes by methylenedioxymethamphetamine (MDMA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Interactions of amphetamine analogs with human liver CYP2D6

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

In vitro and in vivo models for assessing drug efflux transporter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534

The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01652176.2011.642534