The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate-binding pocket (Q34221144)

31 July 2017

The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate-binding pocket (English)

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31 July 2017

transmembrane protein

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Wayne F Flintoff

1

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31 July 2017

Frederick M R Williams

series ordinal

2

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31 July 2017

Heather Sadlish

series ordinal

3

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31 July 2017

language of work or name

English

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publication date

8 August 2003

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Journal of Biological Chemistry

31 July 2017

10

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based on heuristic

inferred from page(s)

published in

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31 July 2017

278

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31 July 2017

42

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31 July 2017

40867-40876

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Carrier-mediated membrane transport of folates in mammalian cells

31 July 2017

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https://api.crossref.org/works/10.1074%2FJBC.M302102200

Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Molecular and cellular biology of the human reduced folate carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

The reduced folate carrier in L1210 murine leukemia cells is a 58-kDa protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Analysis of membrane topology of the human reduced folate carrier protein by hemagglutinin epitope insertion and scanning glycosylation insertion mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Intracellular trafficking and membrane targeting mechanisms of the human reduced folate carrier in Mammalian epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Role of the C-terminus and the long cytoplasmic loop in reduced folate carrier expression and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter w

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

The role of cysteine residues in the erythrocyte plasma membrane anion exchange protein, AE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Locating the anion-selectivity filter of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Functional role of arginine 373 in substrate translocation by the reduced folate carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Biotinylation of single cysteine mutants of the glutamate transporter GLT-1 from rat brain reveals its unusual topology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

The green fluorescent protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Characterization of a cysteine-less human reduced folate carrier: localization of a substrate-binding domain by cysteine-scanning mutagenesis and cysteine accessibility methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Membrane topology of a cysteine-less mutant of human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Topology of the region surrounding Glu681 of human AE1 protein, the erythrocyte anion exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Transport of methotrexate in Chinese hamster ovary cells: a mutant defective in methotrexate uptake and cell binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Effects of the loss of capacity for N-glycosylation on the transport activity and cellular localization of the human reduced folate carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Mutant Chinese hamster ovary cells with defective methotrexate uptake are distinguishable by reversion analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

Mapping the ends of transmembrane segments in a polytopic membrane protein. Scanning N-glycosylation mutagenesis of extracytosolic loops in the anion exchanger, band 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302102200

21 January 2018

Identifiers

DOI

10.1074/JBC.M302102200

1 reference

31 July 2017

1 reference