Functional role of arginine 373 in substrate translocation by the reduced folate carrier (Q40708684)

23 September 2017

Functional role of arginine 373 in substrate translocation by the reduced folate carrier (English)

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23 September 2017

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Heather Sadlish

1

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23 September 2017

Frederick M R Williams

series ordinal

2

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23 September 2017

Wayne F Flintoff

series ordinal

3

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23 September 2017

language of work or name

English

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publication date

22 August 2002

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Journal of Biological Chemistry

23 September 2017

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23 September 2017

277

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23 September 2017

44

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23 September 2017

42105-42112

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Folic acid: nutritional biochemistry, molecular biology, and role in disease processes

23 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Down-regulation of reduced folate carrier gene (RFC1) expression after exposure to methotrexate in ZR-75-1 breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Role of the C-terminus and the long cytoplasmic loop in reduced folate carrier expression and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter w

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Mutations in the reduced-folate carrier affect protein localization and stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Isolation of high-molecular-weight DNA from mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Proximity of periplasmic loops in the lactose permease of Escherichia coli determined by site-directed cross-linking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Helix proximity in OxlT, the oalate:formate antiporter of oxalobacter formigenes. Cross-linking between TM2 and TM11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Conformational changes that occur during M3 muscarinic acetylcholine receptor activation probed by the use of an in situ disulfide cross-linking strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Functional interactions between arginine-133 and aspartate-88 in the human reduced folate carrier: evidence for a charge-pair association

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Transport of methotrexate in Chinese hamster ovary cells: a mutant defective in methotrexate uptake and cell binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Genetic characterization of methotrexate-resistant chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Mutant Chinese hamster ovary cells with defective methotrexate uptake are distinguishable by reversion analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

Chromosomal localization of the reduced folate transporter gene (SLC19A1) in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206459200

21 January 2018

Identifiers

DOI

10.1074/JBC.M206459200

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23 September 2017

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