A critical review of the molecular pathophysiology of lenalidomide sensitivity in 5q - myelodysplastic syndromes (Q34220013)

31 July 2017

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title

A critical review of the molecular pathophysiology of lenalidomide sensitivity in 5q - myelodysplastic syndromes (English)

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31 July 2017

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Ioannis A Voutsadakis

series ordinal

1

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PubMed ID

21955212

31 July 2017

Anne Cairoli

series ordinal

2

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PubMed ID

21955212

31 July 2017

language of work or name

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25 November 2011

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31 July 2017

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31 July 2017

53

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31 July 2017

5

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31 July 2017

779-788

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Deletion 5q in myelodysplastic syndrome: a paradigm for the study of hemizygous deletions in cancer

31 July 2017

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

New insights into 5q- syndrome as a ribosomopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Clinical, morphological, cytogenetic, and prognostic features of patients with myelodysplastic syndromes and del(5q) including band q31

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Biological and prognostic significance of chromosome 5q deletions in myeloid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

The evolution of thalidomide and its IMiD derivatives as anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Mechanism of action of lenalidomide in hematological malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Thalidomide and lenalidomide: Mechanism-based potential drug combinations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Testing the NKT cell hypothesis in lenalidomide-treated myelodysplastic syndrome patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Lenalidomide inhibits proliferation of Namalwa CSN.70 cells and interferes with Gab1 phosphorylation and adaptor protein complex assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Nuclear factor-kappaB in cancer development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Lenalidomide induces cell death in an MDS-derived cell line with deletion of chromosome 5q by inhibition of cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Pathophysiology and treatment of the myelodysplastic syndrome with isolated 5q deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Efficacy and safety of lenalidomide in intermediate-2 or high-risk myelodysplastic syndromes with 5q deletion: results of a phase 2 study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Phase 2 study of lenalidomide in transfusion-dependent, low-risk, and intermediate-1 risk myelodysplastic syndromes with karyotypes other than deletion 5q.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

The role of lenalidomide in the management of myelodysplasia with del 5q.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Delineation by molecular cytogenetics of 5q deletion breakpoints in myelodyplastic syndromes and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Cell biology. Turning off inflammation signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

The widespread regulation of microRNA biogenesis, function and decay

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Glutathione peroxidases in different stages of carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Rasputin, more promiscuous than ever: a review of G3BP

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Annexin A6 inhibits Ras signalling in breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Annexin A6-regulator of the EGFR/Ras signalling pathway and cholesterol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Microarray-based comparative genomic hybridisation of breast cancer patients receiving neoadjuvant chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Casein kinase 1alpha interacts with RIP1 and regulates NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Interleukin-17 family and IL-17 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

NF-κB as a potential therapeutic target in myelodysplastic syndromes and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Therapeutic targeting of NF-κB in myelodysplastic syndromes and acute myeloid leukaemia - the biological heterogeneity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Adherens junctions: from molecules to morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Modulation of matrix remodeling by SPARC in neoplastic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

SPARC mediates focal adhesion disassembly in endothelial cells through a follistatin-like region and the Ca(2+)-binding EF-hand.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

SPARC (secreted protein acidic and rich in cysteine) induces apoptosis in ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Mechanism and function of formins in the control of actin assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

5q- myelodysplastic syndromes: chromosome 5q genes direct a tumor-suppression network sensing actin dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Epigenetic silencing of the sulfate transporter gene DTDST induces sialyl Lewisx expression and accelerates proliferation of colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

New insights into Fat cadherins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Human Fat2 is localized at immature adherens junctions in epidermal keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

abLIM3 is a novel component of adherens junctions with actin-binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

UV as an amplifier rather than inducer of NF-kappaB activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Treacher Collins syndrome: unmasking the role of Tcof1/treacle

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Heparan sulphate proteoglycans fine-tune mammalian physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Involvement of PP2A in viral and cellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

PP2A fulfills its promises as tumor suppressor: which subunits are important?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

PP2A: unveiling a reluctant tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

CDC25 phosphatases in cancer cells: key players? Good targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Emerging roles of microRNAs in the control of embryonic stem cells and the generation of induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Balancing dormant and self-renewing hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Persistent malignant stem cells in del(5q) myelodysplasia in remission

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Expression of TNF receptors and related signaling molecules in the bone marrow from patients with myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Apoptosis and antiapoptotic mechanisms in the progression of myelodysplastic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Lenalidomide in patients with refractory or multiple relapsed Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's Lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Oncogenic activation of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

Impact of adjunct cytogenetic abnormalities for prognostic stratification in patients with myelodysplastic syndrome and deletion 5q

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.623255

10.3109/10428194.2011.623255

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

21955212