In vivo manganese exposure modulates Erk, Akt and Darpp-32 in the striatum of developing rats, and impairs their motor function (Q34200391)

31 July 2017

In vivo manganese exposure modulates Erk, Akt and Darpp-32 in the striatum of developing rats, and impairs their motor function (English)

1 reference

31 July 2017

1 reference

Fabiano M Cordova

1

0 references

Mark W. Lopes

Mark W Lopes

4

0 references

Tanara V. Peres

Tanara V Peres

3

0 references

Alexandra Latini

Alexandra S Latini

9

0 references

Aderbal S. Aguiar

Aderbal S Aguiar

2

0 references

Rodrigo B. Leal

Rodrigo B Leal

13

0 references

Michael Aschner

12

Michael Aschner

1 reference

31 July 2017

Filipe M Gonçalves

5

1 reference

31 July 2017

Aline P Remor

6

1 reference

31 July 2017

Samantha C Lopes

7

1 reference

31 July 2017

Célso Pilati

8

1 reference

31 July 2017

Rui D S Prediger

10

1 reference

31 July 2017

Keith M Erikson

11

1 reference

31 July 2017

language of work or name

English

0 references

publication date

13 March 2012

1 reference

31 July 2017

1 reference

31 July 2017

7

1 reference

31 July 2017

3

1 reference

31 July 2017

e33057

1 reference

Creative Commons Attribution 4.0 International

31 July 2017

start time

13 March 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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28 July 2018

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Manganese exposure alters the expression of N-methyl-D-aspartate receptor subunit mRNAs and proteins in rat striatum

28 July 2018

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Manganese-mediated up-regulation of HIF-1alpha protein in Hep2 human laryngeal epithelial cells via activation of the family of MAPKs

28 July 2018

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Manganese exposure and the neuropsychological effect on children and adolescents: a review

28 July 2018

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Individual differences in the effects of cannabinoids on motor activity, dopaminergic activity and DARPP-32 phosphorylation in distinct regions of the brain

28 July 2018

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alpha-Synuclein overexpression during manganese-induced apoptosis in SH-SY5Y neuroblastoma cells

28 July 2018

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Manganese (Mn) and iron (Fe): interdependency of transport and regulation

28 July 2018

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Manganese in parenteral nutrition: who, when, and why should we supplement?

28 July 2018

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Lifetime cumulative exposure as a threat for neurodegeneration: need for prevention strategies on a global scale

28 July 2018

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Induction of oxidative stress and inflammatory cytokines by manganese chloride in cultured T98G cells, human brain glioblastoma cell line

28 July 2018

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Developmental exposure to manganese increases adult susceptibility to inflammatory activation of glia and neuronal protein nitration

28 July 2018

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Age-dependent susceptibility to manganese-induced neurological dysfunction

28 July 2018

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Are there common biochemical and molecular mechanisms controlling manganism and parkisonism

28 July 2018

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Manganese and its role in Parkinson's disease: from transport to neuropathology

28 July 2018

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Oxidative damage and neurodegeneration in manganese-induced neurotoxicity

28 July 2018

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Manganese-induced dopaminergic neurodegeneration: insights into mechanisms and genetics shared with Parkinson's disease

28 July 2018

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Manganese disrupts astrocyte glutamine transporter expression and function

28 July 2018

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Manganese neurotoxicity: lessons learned from longitudinal studies in nonhuman primates

28 July 2018

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Effects of chronic manganese exposure on working memory in non-human primates

28 July 2018

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Manganese exposure, essentiality & toxicity.

28 July 2018

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The effects of environmental neurotoxicants on the dopaminergic system: A possible role in drug addiction

28 July 2018

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Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes

28 July 2018

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Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures

28 July 2018

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Developmental impacts of heavy metals and undernutrition

28 July 2018

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Mitochondrial-mediated apoptosis in neural stem cells exposed to manganese.

28 July 2018

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Sub-cellular localization of manganese in the basal ganglia of normal and manganese-treated rats An electron spectroscopy imaging and electron energy-loss spectroscopy study

28 July 2018

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The neuropathology of manganese-induced Parkinsonism

28 July 2018

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Association between manganese exposure through drinking water and infant mortality in Bangladesh

28 July 2018

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Manganese: recent advances in understanding its transport and neurotoxicity

28 July 2018

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Exposure of C6 glioma cells to Pb(II) increases the phosphorylation of p38(MAPK) and JNK1/2 but not of ERK1/2.

28 July 2018

1 reference

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Developmental neurotoxicity of industrial chemicals

28 July 2018

1 reference

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Manganese neurotoxicity: a focus on the neonate

28 July 2018

1 reference

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Insulin signaling in the central nervous system: learning to survive

28 July 2018

1 reference

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ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties

28 July 2018

1 reference

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MAPK signal specificity: the right place at the right time

28 July 2018

1 reference

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Extracellular signal-regulated kinase as an inducer of non-apoptotic neuronal death

28 July 2018

1 reference

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Manganese induces inducible nitric oxide synthase (iNOS) expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells

28 July 2018

1 reference

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The basal ganglia: learning new tricks and loving it.

28 July 2018

1 reference

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Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302787

Developmental neurotoxicology

28 July 2018

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Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells.

28 July 2018

1 reference

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Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae.

28 July 2018

1 reference

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Oxidative neuronal injury. The dark side of ERK1/2.

28 July 2018

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Neurodegenerative and physiological actions of c-Jun N-terminal kinases in the mammalian brain

28 July 2018

1 reference

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Advances in protein kinase B signalling: AKTion on multiple fronts

28 July 2018

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28 July 2018

Manganese neurotoxicity

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MAPK cascade signalling and synaptic plasticity

28 July 2018

1 reference

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Protein measurement with the Folin phenol reagent

28 July 2018

1 reference

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DARPP-32: an integrator of neurotransmission

28 July 2018

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Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese

28 July 2018

1 reference

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Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress

28 July 2018

1 reference

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28 July 2018

1 reference

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The neurobiology of slow synaptic transmission

28 July 2018

1 reference

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Mammalian MAP kinase signalling cascades

28 July 2018

1 reference

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Calcium sequestering ability of mitochondria modulates influx of calcium through glutamate receptor channel.

28 July 2018

1 reference

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The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory.

28 July 2018

1 reference

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Amplification of dopaminergic signaling by a positive feedback loop

28 July 2018

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JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous system

28 July 2018

1 reference

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Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade

28 July 2018

1 reference

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Developing brain as a target of toxicity

28 July 2018

1 reference

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Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?

28 July 2018

1 reference

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The oxidative inactivation of mitochondrial electron transport chain components and ATPase.

28 July 2018

1 reference

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Rodent Brain Growth Stages: An Analytical Review

28 July 2018

1 reference

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A simplification of the protein assay method of Lowry et al. which is more generally applicable

28 July 2018

1 reference

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Nutritional aspects of manganese homeostasis.

28 July 2018

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Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain

21 January 2018

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Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models

21 January 2018

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Temporal parenteral nutrition in children causing t1 shortening in the anterior pituitary gland and globus pallidus.

21 January 2018

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Trace element supplementation in parenteral nutrition: pharmacy, posology, and monitoring guidance

21 January 2018

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A manganese-enhanced diet alters brain metals and transporters in the developing rat.

21 January 2018

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Acute manganese administration alters dopamine transporter levels in the non-human primate striatum

21 January 2018

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Inhibition of DAT function attenuates manganese accumulation in the globus pallidus

21 January 2018

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In vitro effect of manganese chloride exposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain

21 January 2018

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In vitro effect of manganese chloride exposure on energy metabolism and oxidative damage of mitochondria isolated from rat brain.

21 January 2018

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Molecular mechanism of manganese exposure-induced dopaminergic toxicity

21 January 2018

1 reference

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Involvement of striatal lipid peroxidation and inhibition of calcium influx into brain slices in neurobehavioral alterations in a rat model of short-term oral exposure to manganese

21 January 2018

1 reference

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Vitamin A supplementation induces a prooxidative state in the striatum and impairs locomotory and exploratory activity of adult rats.

21 January 2018

1 reference

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Glutamate/aspartate transporter (GLAST), taurine transporter and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfate

21 January 2018

1 reference

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Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells.

21 January 2018

1 reference

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p44/42 MAP kinase and c-Jun N-terminal kinase contribute to the up-regulation of caspase-3 in manganese-induced apoptosis in PC12 cells.

21 January 2018

1 reference

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Manganese activates the mitochondrial apoptotic pathway in rat astrocytes by modulating the expression of proteins of the Bcl-2 family.

21 January 2018

1 reference

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Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion

21 January 2018

1 reference

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Manganese induces the overexpression of α-synuclein in PC12 cells via ERK activation.

21 January 2018

1 reference

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Manganese induces tau hyperphosphorylation through the activation of ERK MAPK pathway in PC12 cells

21 January 2018

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The bright side of JNKs-Multitalented mediators in neuronal sprouting, brain development and nerve fiber regeneration

21 January 2018

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Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit

21 January 2018

1 reference

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Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia.

21 January 2018

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Blockade of adenosine A2A receptors downregulates DARPP-32 but increases ERK1/2 activity in striatum of dopamine deficient "weaver" mouse

21 January 2018

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Striatal inhibition of PKA prevents levodopa-induced behavioural and molecular changes in the hemiparkinsonian rat.

21 January 2018

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Lead stimulates ERK1/2 and p38MAPK phosphorylation in the hippocampus of immature rats.

21 January 2018

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Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imaging

21 January 2018

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3-Hydroxyglutaric acid moderately impairs energy metabolism in brain of young rats.

21 January 2018

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In vitro effect of quinolinic acid on energy metabolism in brain of young rats.

21 January 2018

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Regulation of intrinsic prion protein by growth factors and TNF-alpha: the role of intracellular reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

Manganese induces oxidative impairment in cultured rat astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

9-Benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

Physical exercise improves motor and short-term social memory deficits in reserpinized rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

Morphological changes and manganese content in the brains of rat pups subjected to subchronic poisoning with manganese chloride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

Effects of manganese (Mn) on the developing rat brain: oxidative-stress related endpoints.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

Assessment of bioaccumulation, neuropathology, and neurobehavior following subchronic (90 days) inhalation in Sprague-Dawley rats exposed to manganese phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

Enhanced number and activity of mitochondria in multiple sclerosis lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

Nitric oxide and peroxynitrite interactions with mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

Manganese induces sustained Ser40 phosphorylation and activation of tyrosine hydroxylase in PC12 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

Induction of cyclooxygenase-2 expression by manganese in cultured astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

Psychoactive drugs and regulation of the cAMP/PKA/DARPP-32 cascade in striatal medium spiny neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

Regulation of DARPP-32 phosphorylation by Δ9-tetrahydrocannabinol

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0033057

Aquaporin-4 in manganese-treated cultured astrocytes

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302787

Measurement of isoprostanes as markers of oxidative stress in neuronal tissue

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302787

Manganese uptake into rat brain during development and aging.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302787

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3302787

Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress

28 October 2018

1 reference

12 December 2020

1 reference

12 December 2020

Coordinate induction of energy gene expression in tissues of mitochondrial disease patients

1 reference

12 December 2020

Manganese transport through human erythrocyte membranes. An EPR study

1 reference

12 December 2020

Effect of treatment with mercury chloride and lead acetate during the second stage of rapid postnatal brain growth on delta-aminolevulinic acid dehydratase (ALA-D) activity in brain, liver, kidney and blood of suckling rats

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0033057

Identifiers

DOI

1 reference

31 July 2017

0 references

1 reference

31 July 2017

1 reference