Are there common biochemical and molecular mechanisms controlling manganism and parkisonism (Q37598121)

21 August 2017

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title

Are there common biochemical and molecular mechanisms controlling manganism and parkisonism (English)

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21 August 2017

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Jerome A Roth

1

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21 August 2017

16 September 2009

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21 August 2017

NeuroMolecular Medicine

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21 August 2017

11

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21 August 2017

4

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21 August 2017

281-296

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https://scigraph.springernature.com/pub.10.1007/s12017-009-8088-8

21 August 2017

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Role of iron in neurodegenerative disorders

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Vulnerability of mitochondrial complex I in PC12 cells exposed to manganese

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The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms

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Manganese disrupts astrocyte glutamine transporter expression and function

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Issues in neurological risk assessment for occupational exposures: the Bay Bridge welders

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Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in MES23.5 cells

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Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function

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12 December 2020

Manganese cumulative exposure and symptoms: a follow-up study of alloy workers

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Manganese and chronic hepatic encephalopathy

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The influence of the subthalamic nucleus upon the damage to the dopamine system following lesions of globus pallidus in rats.

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Selective vulnerability of pallidal neurons in the early phases of manganese intoxication.

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Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells

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A chronic iron-deficient/high-manganese diet in rodents results in increased brain oxidative stress and behavioral deficits in the morris water maze.

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12 December 2020

Age-standardized incidence and prevalence of Parkinson's disease in a Swedish community

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[Hearing reduction caused by manganese and noise]

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12 December 2020

Increased manganese concentrations in pallidum of cirrhotic patients

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12 December 2020

The effect of deficiencies of manganese and copper on osteoinduction and on resorption of bone particles in rats

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12 December 2020

Molecular and cellular mechanisms underlying iron transport deficiency in microcytic anemia

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12 December 2020

Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells.

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12 December 2020

Manganese-induced rat pheochromocytoma (PC12) cell death is independent of caspase activation

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12 December 2020

Occupational health concerns in the welding industry.

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12 December 2020

Effects from environmental Mn exposures: a review of the evidence from non-occupational exposure studies.

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12 December 2020

Manganese decreases glutamate uptake in cultured astrocytes

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12 December 2020

Whole blood and red blood cell manganese reflected signal intensities of T1-weighted magnetic resonance images better than plasma manganese in liver cirrhotics.

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12 December 2020

NF-kappaB signaling pathway and its therapeutic implications in human diseases

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12 December 2020

Role of oxidative stress in the manganese and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced apoptosis in PC12 cells

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12 December 2020

Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease.

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12 December 2020

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

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12 December 2020

Activation of JNK pathway and induction of apoptosis by manganese in PC12 cells.

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12 December 2020

Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum

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12 December 2020

Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytes

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12 December 2020

Regulation of genes of iron metabolism by the iron-response proteins

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12 December 2020

Activation of ERK1 and ERK2 is required for manganese-induced neurite outgrowth in rat pheochromocytoma (PC12) cells

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12 December 2020

Effect of the iron chelator desferrioxamine on manganese-induced toxicity of rat pheochromocytoma (PC12) cells

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12 December 2020

Mn2+ sequestration by mitochondria and inhibition of oxidative phosphorylation

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12 December 2020

Expression of the 1B isoforms of divalent metal transporter (DMT1) is regulated by interaction of NF-Y with a CCAAT-box element near the transcription start site

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12 December 2020

Identification of transferrin as the major plasma carrier protein for manganese introduced orally or intravenously or after in vitro addition in the rat

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12 December 2020

Manganese oxidation state mediates toxicity in PC12 cells

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12 December 2020

Brain MR imaging in patients with hepatic cirrhosis: relationship between high intensity signal in basal ganglia on T1-weighted images and elemental concentrations in brain

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12 December 2020

Manganese-induced potentiation of in vitro proinflammatory cytokine production by activated microglial cells is associated with persistent activation of p38 MAPK.

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12 December 2020

TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells.

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12 December 2020

Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle

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12 December 2020

Dynamic Traffic through the Recycling Compartment Couples the Metal Transporter Nramp2 (DMT1) with the Transferrin Receptor

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12 December 2020

Epidemiological survey among workers exposed to manganese: effects on lung, central nervous system, and some biological indices.

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12 December 2020

Dopamine transporter density is decreased in parkinsonian patients with a history of manganese exposure: what does it mean?

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12 December 2020

Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency

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12 December 2020

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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12 December 2020

Glutamate-dependent transcriptional regulation in bergmann glia cells: involvement of p38 MAP kinase.

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12 December 2020

Proinflammatory cytokines increase iron uptake into human monocytes and synovial fibroblasts from patients with rheumatoid arthritis

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12 December 2020

Speciation of manganese in cells and mitochondria: a search for the proximal cause of manganese neurotoxicity

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12 December 2020

Alternative splicing regulates the subcellular localization of divalent metal transporter 1 isoforms

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12 December 2020

Occupational and environmental exposures and nonspecific lung disease--a review of selected studies

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12 December 2020

Hypoxia induces changes in expression of isoforms of the divalent metal transporter (DMT1) in rat pheochromocytoma (PC12) cells.

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12 December 2020

Manganese: a transition metal protects nigrostriatal neurons from oxidative stress in the iron-induced animal model of parkinsonism.

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12 December 2020

Motor cortical control of internal pallidal activity through glutamatergic and GABAergic inputs in awake monkeys

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12 December 2020

Time to re-evaluate the guideline value for manganese in drinking water?

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12 December 2020

Positron emission tomography in manganese intoxication

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12 December 2020

Prenatal manganese levels linked to childhood behavioral disinhibition

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12 December 2020

Behavioral effects of subchronic inorganic manganese exposure in rats.

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12 December 2020

Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Possible implications for the regulation of iron absorption

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12 December 2020

Manganese Poisoning in Moroccan Miners

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12 December 2020

Dose-effect relationships between manganese exposure and neurological, neuropsychological and pulmonary function in confined space bridge welders

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12 December 2020

Morphological organization of the globus pallidus-subthalamic nucleus system studied in organotypic cultures

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12 December 2020

Distinct targeting and recycling properties of two isoforms of the iron transporter DMT1 (NRAMP2, Slc11A2).

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12 December 2020

Effect of levodopa treatment for parkinsonism in welders: A double-blind study

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12 December 2020

NF-kappaB-dependent production of nitric oxide by astrocytes mediates apoptosis in differentiated PC12 neurons following exposure to manganese and cytokines

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12 December 2020

A study of the relationships between Parkinson's disease and markers of traffic-derived and environmental manganese air pollution in two Canadian cities

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12 December 2020

Decrease in spontaneous motor activity and in brain lipid peroxidation in manganese and melatonin treated mice.

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12 December 2020

Expression of the two mRNA isoforms of the iron transporter Nramp2/DMTI in mice and function of the iron responsive element

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12 December 2020

The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake

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12 December 2020

Death of dopaminergic neurones in the rat substantia nigra can be induced by damage to globus pallidus.

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12 December 2020

Welding occupations and mortality from Parkinson's disease and other neurodegenerative diseases among United States men, 1985-1999.

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12 December 2020

Oxidative stress involves in astrocytic alterations induced by manganese

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12 December 2020

Expression and localization of different forms of DMT1 in normal and tumor astroglial cells

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12 December 2020

Prevalence and incidence of Parkinson's disease in Europe

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12 December 2020

ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties

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12 December 2020

Short-term inhalation exposure to mild steel welding fume had no effect on lung inflammation and injury but did alter defense responses to bacteria in rats

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12 December 2020

Increased basal ganglia iron levels in Huntington disease

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12 December 2020

Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases

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12 December 2020

Lung injury after ozone exposure is iron dependent

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12 December 2020

Progressive motor syndrome in a welder with pallidal T1 hyperintensity on MRI: A two-year follow-up.

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12 December 2020

NMDA receptor/L-VGCC-dependent expression and AMPA/KA receptor-dependent activation of c-Jun induced by cerebral ischemia in rat hippocampus

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12 December 2020

Idiopathic parkinsonism with superimposed manganese exposure: utility of positron emission tomography

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12 December 2020

Amyotrophic lateral sclerosis: T2 shortening in motor cortex at MR imaging

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12 December 2020

Potentiating effects of manganese dioxide on experimental respiratory infections

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12 December 2020

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

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12 December 2020

Iron accumulation in the substantia nigra of patients with Alzheimer disease and parkinsonism.

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12 December 2020

Manganese intoxication and chronic liver failure

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12 December 2020

Subcellular and subsynaptic distribution of the NR1 subunit of the NMDA receptor in the neostriatum and globus pallidus of the rat: co-localization at synapses with the GluR2/3 subunit of the AMPA receptor

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12 December 2020

Functional characterization of GABAergic pallidopallidal and striatopallidal synapses in the rat globus pallidus in vitro

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12 December 2020

Protection against glutamate toxicity through inhibition of the p44/42 mitogen-activated protein kinase pathway in neuronally differentiated P19 cells

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12 December 2020

Hepcidin inhibits apical iron uptake in intestinal cells.

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12 December 2020

[Auditory-vestibular changes in workers in ferrous metallurgy manufacture]

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12 December 2020

Manganese transport through human erythrocyte membranes. An EPR study

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12 December 2020

NF-kappaB in the survival and plasticity of neurons

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12 December 2020

Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

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12 December 2020

Distribution and roles of metabotropic glutamate receptors in the basal ganglia motor circuit: implications for treatment of Parkinson's disease and related disorders

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12 December 2020

Manganese accumulation in the mouse ear following systemic exposure

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12 December 2020

Neurologic manifestations in welders with pallidal MRI T1 hyperintensity.

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12 December 2020

High signal intensities on T1-weighted MRI as a biomarker of exposure to manganese

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12 December 2020

Neurological and neuropsychological features in Parkinsonian patients exposed to neurotoxic metals

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12 December 2020

Persistent effects of manganese on effortful responding and their relationship to manganese accumulation in the primate globus pallidus

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12 December 2020

The G185R mutation disrupts function of the iron transporter Nramp2

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12 December 2020

Parkinson's disease: from monogenic forms to genetic susceptibility factors

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12 December 2020

Calcium sequestering ability of mitochondria modulates influx of calcium through glutamate receptor channel.

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12 December 2020

Performance alterations associated with occupational exposure to manganese--a meta-analysis.

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12 December 2020

Nitric oxide transcriptionally down-regulates specific isoforms of divalent metal transporter (DMT1) via NF-kappaB.

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12 December 2020

Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line

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12 December 2020

[18F]FDOPA PET and clinical features in parkinsonism due to manganism

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12 December 2020

Implications for atypical antioxidative properties of manganese in iron-induced brain lipid peroxidation and copper-dependent low density lipoprotein conjugation.

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12 December 2020

Parkinsonism induced by chronic manganese intoxication--an experience in Taiwan.

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12 December 2020

Manganese induces endoplasmic reticulum (ER) stress and activates multiple caspases in nigral dopaminergic neuronal cells, SN4741.

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12 December 2020

Retention and clearance of stainless steel shieldgas welding fumes in rat lungs

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12 December 2020

GluR6-containing KA receptor mediates the activation of p38 MAP kinase in rat hippocampal CA1 region during brain ischemia injury

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12 December 2020

Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion

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12 December 2020

Manganese pneumonitis; further clinical and experimental observations.

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12 December 2020

Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures

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12 December 2020

Manganese intoxication and parenteral nutrition

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12 December 2020

Manganese and 1-methyl-4-(2'-ethylpheny1)-1,2,3,6-tetrahydropyridine induce apoptosis in PC12 cells

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12 December 2020

Teratogenic aspects of manganese, zinc, and copper nutrition

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12 December 2020

Manganese neurotoxicity: a review of clinical features, imaging and pathology.

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12 December 2020

A preliminary study revealing a new association in patients undergoing maintenance hemodialysis: manganism symptoms and T1 hyperintense changes in the basal ganglia.

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12 December 2020

Iron-dependent regulation of the divalent metal ion transporter

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12 December 2020

Secondary progressive chronic manganism associated with markedly decreased striatal D2 receptor density

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12 December 2020

Chronic parkinsonism associated with cirrhosis: a distinct subset of acquired hepatocerebral degeneration.

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12 December 2020

Respiratory effects from work-related exposure to welding fumes in Hamadan, Iran.

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12 December 2020

Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism

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12 December 2020

Manganese: a review of occupational and environmental toxicology

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12 December 2020

Regulation of iron acquisition and storage: consequences for iron-linked disorders

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12 December 2020

Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese

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12 December 2020

Parkin attenuates manganese-induced dopaminergic cell death

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12 December 2020

Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells

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12 December 2020

High prevalence of Parkinsonian disorders associated to manganese exposure in the vicinities of ferroalloy industries

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12 December 2020

Influence of parenteral iron preparations on non-transferrin bound iron uptake, the iron regulatory protein and the expression of ferritin and the divalent metal transporter DMT-1 in HepG2 human hepatoma cells.

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12 December 2020

Manganese induces apoptosis of human B cells: caspase-dependent cell death blocked by bcl-2.

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12 December 2020

Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease.

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12 December 2020

Identification and characterization of a second mouse Nramp gene.

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12 December 2020

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

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12 December 2020

Neuropsychological function in manganese alloy plant workers

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12 December 2020

Clinical genetics of Parkinson's disease and related disorders

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12 December 2020

Post-translational and transcriptional regulation of DMT1 during P19 embryonic carcinoma cell differentiation by retinoic acid

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12 December 2020

Nutrition versus toxicology of manganese in humans: evaluation of potential biomarkers

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12 December 2020

Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter

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12 December 2020

Manganese induces inducible nitric oxide synthase (iNOS) expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells

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12 December 2020

Molecular basis of Parkinson's disease

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12 December 2020

Comparison of high MRI T1 signals with manganese concentration in brains of cynomolgus monkeys after 8 months of stainless steel welding-fume exposure.

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12 December 2020

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

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12 December 2020

The natural history of neurological manganism over 18 years.

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12 December 2020

Effects of long-term dietary manganese and copper deficiency on rat skeleton

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12 December 2020

High signal intensity on magnetic resonance imaging is a better predictor of neurobehavioral performances than blood manganese in asymptomatic welders.

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12 December 2020

The diagnosis of manganese-induced parkinsonism

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12 December 2020

The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

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12 December 2020

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

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12 December 2020

Novel protective effect of manganese against ferrous citrate-induced lipid peroxidation and nigrostriatal neurodegeneration in vivo

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12 December 2020

Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications.

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12 December 2020

10.1007/S12017-009-8088-8

Identifiers

DOI

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21 August 2017

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PubMed ID

19757210