Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum (Q34186277)

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English	Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum	scientific article

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9 March 2020

Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum (English)

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9 March 2020

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9 March 2020

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9 March 2020

author name string

Curtis D Klaassen

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17 July 2014

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9 March 2020

Journal of Pharmacology and Experimental Therapeutics

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9 March 2020

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9 March 2020

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9 March 2020

105-113

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9 March 2020

Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism

1 reference

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5 July 2018

Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice

1 reference

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5 July 2018

Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice

1 reference

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5 July 2018

Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice.

1 reference

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5 July 2018

Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS

1 reference

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5 July 2018

Targeting bile-acid signalling for metabolic diseases

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5 July 2018

The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis

1 reference

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5 July 2018

Regulation of hepatic bile acid transporters Ntcp and Bsep expression

1 reference

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5 July 2018

Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine

1 reference

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5 July 2018

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

1 reference

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5 July 2018

Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4165027

5 July 2018

The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4165027

5 July 2018

Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4165027

5 July 2018

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4165027

5 July 2018

The enzymes, regulation, and genetics of bile acid synthesis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4165027

5 July 2018

A G protein-coupled receptor responsive to bile acids

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4165027

5 July 2018

Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4165027

5 July 2018

Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. A transcriptional control of a plausible bile acid transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4165027

5 July 2018

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4165027

5 July 2018

Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4165027

5 July 2018

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4165027

5 July 2018

Bile acids: natural ligands for an orphan nuclear receptor

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5 July 2018

Identification of a nuclear receptor for bile acids

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5 July 2018

Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.

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5 July 2018

Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.

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5 July 2018

P-450 cytochromes: structure and function

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5 July 2018

Role of a hydrophobic polypeptide in the N-terminal region of NADPH-cytochrome P-450 reductase in complex formation with P-450lm

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5 July 2018

The profile of bile acids and their sulfate metabolites in human urine and serum

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28 October 2018

Identification of a hormonal basis for gallbladder filling.

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28 October 2018

Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps).

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28 October 2018

Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.

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28 October 2018

Expression and regulation of the sterol half-transporter genes ABCG5 and ABCG8 in rats

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28 October 2018

ATP-dependent transport of organic anions into isolated basolateral membrane vesicles from rat intestine

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28 October 2018

Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice

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28 October 2018

Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes

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28 October 2018

Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice

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12 December 2020

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Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine

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https://pubmed.ncbi.nlm.nih.gov/25034404

12 December 2020

based on heuristic

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10.1124/JPET.114.216796

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9 March 2020

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9 March 2020

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Europe PubMed Central

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9 March 2020

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