The insulin factory: a tour of the plant surroundings and a visit to the assembly line. The Minkowski lecture 1973 revisited (Q38591483)

4 September 2017

The insulin factory: a tour of the plant surroundings and a visit to the assembly line. The Minkowski lecture 1973 revisited (English)

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4 September 2017

L Orci

1

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4 September 2017

1 August 1985

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4 September 2017

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4 September 2017

28

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4 September 2017

528-546

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4 September 2017

8

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https://scigraph.springernature.com/pub.10.1007/bf00281987

4 September 2017

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cites work

A portrait of the pancreatic B-cell. The Minkowski Award Lecture delivered on July 19, 1973, during the 8th Congress of the International Diabetes Federation, held in Brussels, Belgium

1 reference

https://api.crossref.org/works/10.1007%2FBF00281987

Macro- and micro-domains in the endocrine pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00281987

Patterns of cellular and subcellular organization in the endocrine pancreas. The Sir Henry Dale lecture for 1983.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00281987

Detection and kinetic behavior of preproinsulin in pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00281987

Monolayer cell culture of neonatal rat pancreas: an ultrastructural and biochemical study of functioning endocrine cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Beta granule formation in isolated islets of langerhans: a study by electron microscopic radioautography

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00281987

The proliferative response of hepatic peroxidomes of neonatal rats to treatment with SU-13 437 (nafenopin)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00281987

Radioautographic visualization of the incorporation of galactose-3H and mannose-3H by rat thyroids in vitro in relation to the stages of thyroglobulin synthesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Perturbation of vesicular traffic with the carboxylic ionophore monensin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00281987

Nonconverted, amino acid analog-modified proinsulin stays in a Golgi-derived clathrin-coated membrane compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00281987

The Phosphomannosyl Recognition System for Intracellular and Intercellular Transport of Lysosomal Enzymes

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

The mannose-6-phosphate receptor for lysosomal enzymes is concentrated in cis Golgi cisternae

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Ultrastructural localization of the mannose 6-phosphate receptor in rat liver

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

(Pro)insulin associates with Golgi membranes of pancreatic B cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Coated pits, coated vesicles, and receptor-mediated endocytosis

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Membrane recycling by coated vesicles

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Clathrin-immunoreactive sites in the Golgi apparatus are concentrated at the trans pole in polypeptide hormone-secreting cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Clathrin-coated vesicles contain an ATP-dependent proton pump

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Golgi membranes contain an electrogenic H+ pump in parallel to a chloride conductance

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Conversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

The internal pH and membrane potential of the insulin-secretory granule

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Visualization of acidic organelles in intact cells by electron microscopy

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Vesicles and cisternae in the trans Golgi apparatus of human fibroblasts are acidic compartments

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Lysosome function in the regulation of the secretory process in cells of the anterior pituitary gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00281987

Granulolysis in a cells of endocrine pancreas in spontaneous and experimental diabetes in animals

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Insulin, not C-peptide (proinsulin), is present in crinophagic bodies of the pancreatic B-cell

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Role of zinc in insulin biosynthesis. Some possible zinc-insulin interactions in the pancreatic B-cell

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Demonstration of insulin degradation by thiol-protein disulfide oxidoreductase (glutathione-insulin transhydrogenase) and proteinases of pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00281987

Cytosolic insulin-degrading activity in islet-derived tumor cell lines and in normal rat islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00281987

Endocrine Pancreas: Three-Dimensional Reconstruction Shows Two Types of Islets of Langerhans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00281987

Identification of a lobe in the adult human pancreas rich in pancreatic polypeptide

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Collagen matrix promotes reorganization of pancreatic endocrine cell monolayers into islet-like organoids

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Asymmetric budding of viruses in epithelial monlayers: a model system for study of epithelial polarity

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

21 January 2018

Cell adhesion molecules.

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https://api.crossref.org/works/10.1007%2FBF00281987

Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Absence of filipin-sterol complexes from large coated pits on the surface of culture cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF00281987

Ultrastructural localization of intracellular antigens by the use of protein A-gold complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00281987

Evidence for polarization of plasma membrane domains in pancreatic endocrine cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00281987

Polarized distribution of viral envelope proteins in the plasma membrane of infected epithelial cells

21 January 2018

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12 December 2020

A model of the pancreas to illustrate its development

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12 December 2020

Circulating Somatostatin Acts on the Islets of Langerhans by Way of a Somatostatin-Poor Compartment

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12 December 2020

Proteolytic processing in the biosynthesis of insulin and other proteins

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12 December 2020

Pancreatic polypeptide and glucagon : non-random distribution in pancreatic islets

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12 December 2020

Specimen preparation for electron microscopy using low temperature embedding resins

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12 December 2020

Long-term exposure of isolated pancreatic islets to mannoheptulose: evidence for insulin degradation in the beta cell

1 reference

12 December 2020

The pancreatic polypeptide-rich lobe of the human pancreas: definitive identification of its derivation from the ventral pancreatic primordium

1 reference

12 December 2020

A monoclonal antibody to the heavy chain of clathrin

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12 December 2020

The Production and Characterization of Monoclonal Antibodies Specific for Human Proinsulin Using a Sensitive Microdot Assay Procedure*

1 reference

12 December 2020

Vasopressin stimulates formation of coated pits in rat kidney collecting ducts

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12 December 2020

Intracellular degradation of insulin stores by rat pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content

1 reference

12 December 2020

A clathrin-coated, Golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin

1 reference

12 December 2020

Inhibition of islet prohormone to hormone conversion by incorporation of arginine and lysine analogs

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12 December 2020

Human Proinsulin-Specific Antigenic Determinants Identified by Monoclonal Antibodies

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12 December 2020

An ATP-driven proton pump in clathrin-coated vesicles

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12 December 2020

Identifiers

DOI

10.1007/BF00281987

1 reference

PubMed ID

3902543

Dimensions Publication ID

4 September 2017

0 references

1 reference

PubMed ID

3902543