Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling (Q34170848)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25063808%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling (English)

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10 March 2020

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4

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10 March 2020

author name string

Deqiang Zhang

1

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10 March 2020

Xin Tong

2

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10 March 2020

Blake Arthurs

3

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10 March 2020

Liangyou Rui

5

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10 March 2020

Avani Kamath

6

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10 March 2020

Ken Inoki

7

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10 March 2020

Lei Yin

8

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10 March 2020

language of work or name

English

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publication date

25 July 2014

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Journal of Biological Chemistry

10 March 2020

published in

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10 March 2020

volume

289

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10 March 2020

issue

37

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10 March 2020

page(s)

25925-25935

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Overview of epidemiology and contribution of obesity to cardiovascular disease

10 March 2020

cites work

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A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.

28 July 2018

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Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis

28 July 2018

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Global loss of bmal1 expression alters adipose tissue hormones, gene expression and glucose metabolism

28 July 2018

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Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice

28 July 2018

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Circadian disruption leads to insulin resistance and obesity

28 July 2018

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Recruitment of histone methyltransferase G9a mediates transcriptional repression of Fgf21 gene by E4BP4 protein

28 July 2018

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Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2

28 July 2018

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Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression

28 July 2018

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Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c

28 July 2018

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Connecting mTORC1 signaling to SREBP-1 activation

28 July 2018

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Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass

28 July 2018

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Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions.

28 July 2018

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28 July 2018

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Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c

28 July 2018

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Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation

28 July 2018

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Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways

28 July 2018

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Insulin signaling to hepatic lipid metabolism in health and disease.

28 July 2018

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Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver

28 July 2018

1 reference

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Crosstalk between components of circadian and metabolic cycles in mammals

28 July 2018

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28 July 2018

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Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

28 July 2018

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Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

28 July 2018

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FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor

28 July 2018

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The critical role of AKT2 in hepatic steatosis induced by PTEN loss

28 July 2018

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Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism

28 July 2018

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Recent advances in nonalcoholic fatty liver disease

28 July 2018

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mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

28 July 2018

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28 July 2018

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28 July 2018

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mTOR complex 2 in adipose tissue negatively controls whole-body growth

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice.

28 July 2018

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Signalling mechanisms linking hepatic glucose and lipid metabolism

28 July 2018

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Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162191

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

28 July 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

28 July 2018

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Role of the liver in the control of carbohydrate and lipid homeostasis

28 July 2018

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BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis

28 July 2018

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28 July 2018

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Mop3 is an essential component of the master circadian pacemaker in mammals

28 July 2018

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28 July 2018

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Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease.

28 July 2018

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Akt2 is required for hepatic lipid accumulation in models of insulin resistance.

21 January 2018

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Coordination of circadian timing in mammals

21 January 2018

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Transcription regulation within the circadian clock: the E-box and beyond.

21 January 2018

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Lipocalin 13 protein protects against hepatic steatosis by both inhibiting lipogenesis and stimulating fatty acid β-oxidation.

21 January 2018

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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

21 January 2018

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Liver disease and diabetes: association, pathophysiology, and management

21 January 2018

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The role of the lipogenic pathway in the development of hepatic steatosis.

21 January 2018

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Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease

21 January 2018

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CLOCK/BMAL1 is involved in lipid metabolism via transactivation of the peroxisome proliferator-activated receptor (PPAR) response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.567628

"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

21 January 2018

1 reference

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Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock.

21 January 2018

1 reference

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Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.567628

Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

21 January 2018

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Rotating shift work and the metabolic syndrome: a prospective study

21 January 2018

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Effects of rotating shift work on biomarkers of metabolic syndrome and inflammation.

21 January 2018

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Characterization of Peripheral Circadian Clocks in Adipose Tissues

21 January 2018

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Obesity and metabolic syndrome in circadian Clock mutant mice

21 January 2018

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28 October 2018

Identifiers

DOI

10.1074/JBC.M114.567628

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25063808%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25063808%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference