Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders (Q34166903)

31 July 2017

5 references

17 June 2019

2 October 2019

27 September 2020

12 November 2020

21 January 2024

Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders (English)

1 reference

functional gastrointestinal disorder

31 July 2017

main subject

cardiovascular disease

4 references

17 June 2019

2 October 2019

27 September 2020

12 November 2020

1 reference

2 October 2019

1 reference

1 reference

27 September 2020

gastrointestinal agent

1 reference

12 November 2020

1 reference

J Tack

1

1 reference

31 July 2017

M Camilleri

2

1 reference

31 July 2017

L Chang

3

1 reference

31 July 2017

W D Chey

4

1 reference

31 July 2017

J J Galligan

5

1 reference

31 July 2017

B E Lacy

6

1 reference

31 July 2017

S Müller-Lissner

7

1 reference

31 July 2017

E M M Quigley

8

1 reference

31 July 2017

J Schuurkes

9

1 reference

31 July 2017

J H De Maeyer

10

1 reference

31 July 2017

V Stanghellini

11

1 reference

31 July 2017

language of work or name

English

0 references

publication date

22 February 2012

1 reference

Alimentary Pharmacology & Therapeutics

31 July 2017

1 April 2012

5 references

17 June 2019

2 October 2019

27 September 2020

12 November 2020

21 January 2024

6 references

31 July 2017

17 June 2019

2 October 2019

27 September 2020

12 November 2020

21 January 2024

35

1 reference

31 July 2017

issue

7

1 reference

31 July 2017

page(s)

745-767

1 reference

Creative Commons Attribution 2.5 Generic

31 July 2017

copyright license

5 references

17 June 2019

2 October 2019

27 September 2020

12 November 2020

Metabolism of 4-Aminopiperidine Drugs by Cytochrome P450s: Molecular and Quantum Mechanical Insights into Drug Design

21 January 2024

cites work

1 reference

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Pharmacological interventions for non-ulcer dyspepsia

5 July 2018

1 reference

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Review article: metoclopramide and tardive dyskinesia

5 July 2018

1 reference

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Effects of Velusetrag (TD-5108) on gastrointestinal transit and bowel function in health and pharmacokinetics in health and constipation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Selective desensitization of the 5-HT4 receptor-mediated response in pig atrium but not in stomach

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Treatment of chronic constipation: current pharmacologic approaches and future directions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Identification of a novel 5-HT(4) receptor splice variant (r5-HT(4c1)) and preliminary characterisation of specific 5-HT(4a) and 5-HT(4b) receptor antibodies

5 July 2018

1 reference

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Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation--a 12-week, randomized, double-blind, placebo-controlled study

5 July 2018

1 reference

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Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

A placebo-controlled trial of prucalopride for severe chronic constipation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Identification of patients with non-d, non-C irritable bowel syndrome and treatment with renzapride: an exploratory, multicenter, randomized, double-blind, placebo-controlled clinical trial.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

5-HT4 receptor activation facilitates recovery from synaptic rundown and increases transmitter release from single varicosities of myenteric neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Alternative splicing and exon duplication generates 10 unique porcine 5-HT 4 receptor splice variants including a functional homofusion variant

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Refining insights into high-affinity drug binding to the human ether-à-go-go-related gene potassium channel.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Clinical trial: renzapride therapy for constipation-predominant irritable bowel syndrome--multicentre, randomized, placebo-controlled, double-blind study in primary healthcare setting

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Development of drugs for gastrointestinal motor disorders: translating science to clinical need

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

5-HT4 receptor agonists: similar but not the same

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Pharmacology and metabolism of renzapride : a novel therapeutic agent for the potential treatment of irritable bowel syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

The cardiovascular safety profile of renzapride, a novel treatment for irritable bowel syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Tegaserod for the treatment of irritable bowel syndrome and chronic constipation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effect of tegaserod on colonic transit time in male patients with constipation-predominant irritable bowel syndrome.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Safety, tolerability and satisfaction with tegaserod therapy in Asia-Pacific patients with irritable bowel syndrome with constipation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Promotility medications--now and in the future

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Safety and tolerability of tegaserod in patients with chronic constipation: pooled data from two phase III studies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Tegaserod-associated ischemic colitis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Tegaserod is safe, well tolerated and effective in the treatment of patients with non-diarrhoea irritable bowel syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effect of renzapride on transit in constipation-predominant irritable bowel syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Tegaserod-induced myocardial infarction: case report and hypothesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Systematic review: the epidemiology of ischaemic colitis

5 July 2018

1 reference

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Systematic review: incidence of abdominal/pelvic surgery amongst patients using tegaserod in randomized controlled trials

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Review article: clinical implications of enteric and central D2 receptor blockade by antidopaminergic gastrointestinal prokinetics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

5-HT4 receptor ligands: applications and new prospects

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Regulation of GABAergic inhibition by serotonin signaling in prefrontal cortex: molecular mechanisms and functional implications

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Long-term safety of tegaserod in patients with constipation-predominant irritable bowel syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Presynaptic modulation of cholinergic neurotransmission in the human proximal stomach

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Evidence of impaired cisapride metabolism in neonates

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Torsades de pointes ventricular tachycardia induced by mosapride and flecainide in the presence of hypokalemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Evidence for involvement of central 5-HT(4) receptors in cholinergic function associated with cognitive processes: behavioral, electrophysiological, and neurochemical studies.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder

5 July 2018

1 reference

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The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate

5 July 2018

1 reference

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Cisapride provides symptomatic relief in functional dyspepsia associated with gastric myoelectrical abnormality

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers

5 July 2018

1 reference

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Pharmacological characterization of 5-HT4 receptors mediating relaxation of canine isolated rectum circular smooth muscle

5 July 2018

1 reference

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Integrated modelling of the clinical pharmacokinetics of SDZ HTF 919, a novel selective 5-HT4 receptor agonist, following oral and intravenous administration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Influence of grapefruit juice on cisapride pharmacokinetics

5 July 2018

1 reference

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Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain

5 July 2018

1 reference

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Randomised controlled trial of cisapride in preterm infants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Salivary function in patients with reflux esophagitis: effect of cisapride.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

The effect of mosapride, a novel prokinetic, on acid reflux variables in patients with gastro-oesophageal reflux disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effects of cisapride on symptoms and postcibal small-bowel motor function in patients with irritable bowel syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Syncopal episodes associated with cisapride and concurrent drugs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Pharmacokinetic profile of cisapride 20 mg after once- and twice-daily dosing.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

The effect of cisapride in maintaining symptomatic remission in patients with gastro-oesophageal reflux disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Cisapride reduces neonatal postoperative ileus: randomised placebo controlled trial

5 July 2018

1 reference

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Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effects of oral cisapride on small bowel motility in irritable bowel syndrome.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Cisapride in chronic idiopathic constipation: clinical response and effect on colonic transit time

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Gastrointestinal prokinetic benzamides: the pharmacology underlying stimulation of motility

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effects of cisapride on gastric emptying of oil and aqueous meal components, hunger, and fullness

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Objective and subjective results of a randomized, double-blind, placebo-controlled trial using cisapride to treat gastroparesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Postprandial antropyloroduodenal motility and gastric emptying in gastroparesis--effects of cisapride

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

The guinea-pig distal colon--a sensitive preparation for the investigation of 5-HT4 receptor-mediated contractions.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effects of ranitidine and cisapride on acid reflux and oesophageal motility in patients with reflux oesophagitis: a 24 hour ambulatory combined pH and manometry study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Metoclopramide-induced Parkinsonism. Clinical characteristics of ten cases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Measurement of gastric emptying in dyspeptic patients: effect of a new gastrokinetic agent (cisapride)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effect of cisapride on the gastro-oesophageal function in normal human subjects.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Intravenous cisapride accelerates delayed gastric emptying and increases antral contraction amplitude in patients with primary anorexia nervosa.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effect of chronic administration of cisapride on gastric emptying of a solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effect of cisapride on human fasting gallbladder volume: a real-time ultrasonographic study.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Treatment of chronic constipation with cisapride and placebo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effects of oral cisapride on interdigestive jejunal motor activity, psychomotor function, and side-effect profile in healthy man.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Cisapride restores the decreased lower oesophageal sphincter pressure in reflux patients

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Cisapride stimulates propulsive motility patterns in human jejunum

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Cisapride. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disorders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

The effect of oral cisapride on colonic transit

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Cisapride stimulates antral motility and decreases biliary reflux in patients with severe dyspepsia.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effect of cisapride on postprandial gastro-oesophageal reflux

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effect of six weeks of treatment with cisapride in gastroparesis and intestinal pseudoobstruction.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

AS-4370, a novel gastrokinetic agent free of dopamine D2 receptor antagonist properties.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Longterm oral cisapride improves interdigestive antroduodenal motility in dyspeptic patients

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effects of cisapride on parameters of oesophageal motility and on the prolonged intraoesophageal pH test in infants with gastro-oesophageal reflux disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Characterization of 5-HT3 and 'atypical' 5-HT receptors mediating guinea-pig ileal contractions in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effect of cisapride on delayed gastric emptying in gastro-oesophageal reflux disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Long-term efficacy of oral cisapride in symptomatic upper gut dysmotility.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Cisapride in children with chronic intestinal pseudoobstruction. An acute, double-blind, crossover, placebo-controlled trial

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Slow gastric emptying induced by high fat content of meal accelerated by cisapride administered rectally

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

The effects of renzapride, a novel prokinetic agent, in diabetic gastroparesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effects of 5-HT4 receptor stimulation on basal and electrically evoked release of acetylcholine from guinea-pig myenteric plexus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Tachycardia during cisapride treatment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Block of the rapid component of the delayed rectifier potassium current by the prokinetic agent cisapride underlies drug-related lengthening of the QT interval

5 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Coprescribing and codispensing of cisapride and contraindicated drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Pharmacological characterisation of 5-HT receptors positively coupled to adenylyl cyclase in the rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

5-HT4 receptors: cloning and expression of new splice variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Expression and function of 5-HT4 receptors in the mouse enteric nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Serotonergic signalling in the stomach and duodenum of patients with gastroparesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

An improved in vitro bioassay for the study of 5-HT(4) receptors in the human isolated large intestinal circular muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Benzimidazolones and renzapride facilitate acetylcholine release from guinea-pig myenteric plexus via 5-HT4 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

5-HT4 receptors located on cholinergic nerves in human colon circular muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Differential effects of 5-hydroxytryptamine4 receptor agonists at gastric versus cardiac receptors: an operational framework to explain and quantify organ-specific behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Pharmacodynamic effects of a novel prokinetic 5-HT receptor agonist, ATI-7505, in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

The 5-HT2B antagonist and 5-HT4 agonist activities of tegaserod in the anaesthetized rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

The Serotonin 5-HT4 Receptor. 2. Structure-Activity Studies of the Indole Carbazimidamide Class of Agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

The serotonin 5-HT4 receptor. 1. Design of a new class of agonists and receptor map of the agonist recognition site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

The in vivo gastrointestinal activity of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

A comparison of two cohort studies evaluating the safety of cisapride: Prescription-Event Monitoring and a large phase IV study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Does cisapride influence cardiac rhythm? Results of a United States multicenter, double-blind, placebo-controlled pediatric study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Meta-analysis of randomized controlled trials on the benefits and risks of using cisapride for the treatment of gastroesophageal reflux in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Cisapride-induced transmural dispersion of repolarization and torsade de pointes in the canine left ventricular wedge preparation during epicardial stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

QTc interval in infants receiving cisapride

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

A comparison of the pharmacokinetics of two dosing regimens of cisapride and their effects on corrected QT interval in premature infants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

QT prolongation and torsades de pointes associated with concurrent use of cisapride and erythromycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Cisapride for the treatment of constipation in children: A double-blind study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Safety, tolerability, and efficacy of tegaserod over 13 months in patients with chronic constipation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Tegaserod and ischemic colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Tegaserod (Zelnorm) for irritable bowel syndrome: reports of serious diarrhea and intestinal ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Tegaserod, a 5-hydroxytryptamine type 4 receptor partial agonist, is devoid of electrocardiographic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Lack of association of tegaserod with adverse cardiovascular outcomes in a matched case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Functional characterization of contractions to tegaserod in human isolated proximal and distal coronary arteries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Effect of clebopride, antidopaminergic gastrointestinal prokinetics, on cardiac repolarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Dose finding study of mosapride in functional dyspepsia: a placebo-controlled, randomized study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Drug Interaction Between Mosapride and Erythromycin Without Electrocardiographic Changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Influence of mosapride citrate on gastric motility and autonomic nervous function: evaluation by spectral analyses of heart rate and blood pressure variabilities, and by electrogastrography

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Prucalopride, a systemic enterokinetic, for the treatment of constipation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Metabolism and pharmacokinetics of naronapride (ATI-7505), a serotonin 5-HT(4) receptor agonist for gastrointestinal motility disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

The role of age and salivation in acid clearance in symptomatic patients with gastro-oesophageal reflux disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Cisapride inhibits meal-stimulated gastric acid secretion and post-prandial gastric acidity in subjects with gastro-oesophageal reflux disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Effects of cisapride, a new gastrointestinal prokinetic substance, on interdigestive and postprandial motor activity of the distal oesophagus in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Effect of tegaserod on gut transit in male and female subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

The effect of mosapride on oesophageal motor function and acid reflux in patients with gastro-oesophageal reflux disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

The effect of cisapride on oesophageal motility and lower sphincter function in patients with gastro-oesophageal reflux disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Effect of cisapride on nocturnal transient lower oesophageal sphincter relaxations and nocturnal gastro-oesophageal reflux in patients with oesophagitis: a double-blind, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Does the addition of a prokinetic to proton pump inhibitor therapy help reduce duodenogastro-oesophageal reflux in patients with Barrett's oesophagus?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Evaluation of gastric emptying and motility in diabetic gastroparesis with magnetic resonance imaging: effects of cisapride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Increased gastric motility during 5-HT4 agonist therapy reduces response fluctuations in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Effect of cisapride on gastric sensitivity to distension, gastric compliance and duodeno-gastric reflexes in healthy humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Clinical trial: effects of tegaserod on gastric motor and sensory function in patients with functional dyspepsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

The effect of cisapride on duodenal acid exposure in the proximal duodenum in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Effects of prucalopride on colonic transit, anorectal function and bowel habits in patients with chronic constipation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Tegaserod, a 5-HT4 receptor partial agonist, decreases sensitivity to rectal distension in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-à-gogo K(+) channel

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Cisapride versus placebo for 8 weeks on glycemic control and gastric emptying in insulin-dependent diabetes: a double blind cross-over trial.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effect of single and multiple administrations of cisapride on postprandial gallbladder emptying in healthy humans.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effects of cisapride on jejunal motor activity in fasting healthy humans.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491670

Effect of cisapride on distal colonic motility in the early postoperative period following left colonic anastomosis

28 October 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2036.2012.05011.X

Renzapride: a new drug for the treatment of constipation in the irritable bowel syndrome

21 January 2018

1 reference

12 December 2020

Should cisapride be avoided in patients with diabetic gastroparesis?

1 reference

12 December 2020

Placebo-controlled trial of cisapride in postgastrectomy patients with duodenogastroesophageal reflux

1 reference

12 December 2020

AS-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs

1 reference

12 December 2020

The effect of cisapride on delayed colonic transit time in patients with idiopathic Parkinson's disease

1 reference

12 December 2020

Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro

1 reference

12 December 2020

Effect of mosapride on gastrointestinal transit time and diagnostic yield of capsule endoscopy

1 reference

12 December 2020

Clinical efficacy and safety of cisapride and clebopride in the management of chronic functional dyspepsia: a double-blind, randomized study

1 reference

12 December 2020

Cisapride accelerates colonic transit in constipated patients with colonic inertia

1 reference

12 December 2020

Simultaneous determination of clebopride and a major metabolite N-desbenzylclebopride in plasma by capillary gas chromatography—negative-ion chemical ionization mass spectrometry

1 reference

12 December 2020

An estimate of the risk of movement disorders associated with the chronic use of clebopride

1 reference

12 December 2020

Effect of cisapride on gastric and esophageal emptying in insulin-dependent diabetes mellitus

1 reference

12 December 2020

Effect of cisapride on gastric emptying and ileal transit time of balanced liquid meal in healthy subjects

1 reference

12 December 2020

Effects of cisapride on distal esophageal motility in humans

1 reference

12 December 2020

Prokinetic effect of AS-4370 on gastric emptying in healthy adults

1 reference

12 December 2020

The influence of cisapride on gastric tone and the perception of gastric distension

1 reference

12 December 2020

Impaired transit of chyme in chronic intestinal pseudoobstruction. Correction by cisapride

1 reference

12 December 2020

Contraindicated use of cisapride: impact of food and drug administration regulatory action

1 reference

12 December 2020

The effect of cisapride on dyspepsia symptoms and the electrogastrogram in patients with non-ulcer dyspepsia

1 reference

12 December 2020

Pharmacokinetics of the gastrokinetic agent mosapride citrate after single and multiple oral administrations in healthy subjects

1 reference

12 December 2020

A comparative study of cisapride and ranitidine at controlling oesophageal acid exposure in erosive oesophagitis

1 reference

12 December 2020

Effect of cisapride on gastric emptying of indigestible solids in patients with gastroparesis diabeticorum. A comparison with metoclopramide and placebo

1 reference

12 December 2020

The risk of serious cardiac arrhythmias among cisapride users in the United Kingdom and Canada

1 reference

12 December 2020

Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation-predominant irritable bowel syndrome

1 reference

12 December 2020

Effect of AS-4370 on gastric motility in patients with diabetic autonomic neuropathy

1 reference

12 December 2020

Pharmacokinetics of the gastrokinetic agent mosapride citrate after intravenous and oral administrations in dogs and monkeys

1 reference

12 December 2020

5-Hydroxytryptamine4 receptors mediate relaxation of the rat oesophageal tunica muscularis mucosae

1 reference

12 December 2020

Cisapride improves gastric emptying in mechanically ventilated, critically ill patients. A randomized, double-blind trial

1 reference

12 December 2020

The effect of cisapride in patients with reflux esophagitis: an ambulatory esophageal manometry/pH-metry study

1 reference

12 December 2020

Pharmacokinetic characteristics of cisapride in elderly patients

1 reference

12 December 2020

The efficacy of a 40-mg extended-release formulation of cisapride in the treatment of patients with gastro-oesophageal reflux

1 reference

12 December 2020

The effect of cisapride on segmental colonic transit time in patients with spinal cord injury

1 reference

12 December 2020

Effect of cisapride on gastric emptying of indigestible solids and plasma motilin concentration in diabetic autonomic neuropathy

1 reference

12 December 2020

The effect of mosapride on esophageal motility and bolus transit in asymptomatic volunteers

1 reference

12 December 2020

Effect of cisapride, a new prokinetic agent, on esophageal motor function

1 reference

12 December 2020

10.1111/J.1365-2036.2012.05011.X

Identifiers

DOI

1 reference

31 July 2017

1 reference

31 July 2017

1 reference