The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity (Q34770217)

4 August 2017

The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity (English)

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4 August 2017

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J A M Smith

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4 August 2017

D T Beattie

2

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4 August 2017

D Marquess

3

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4 August 2017

J P Shaw

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4 August 2017

R G Vickery

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4 August 2017

P P A Humphrey

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4 August 2017

16 April 2008

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Naunyn-Schmiedeberg's Archives of Pharmacology

4 August 2017

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4 August 2017

378

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4 August 2017

1

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4 August 2017

125-137

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https://scigraph.springernature.com/pub.10.1007/s00210-008-0282-y

4 August 2017

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Tegaserod, a 5-HT4 receptor partial agonist, decreases sensitivity to rectal distension in healthy subjects

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5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine

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Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant

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Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i).

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Distinct 5-HT receptors mediate the peristaltic reflex induced by mucosal stimuli in human and guinea pig intestine

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[3H]RS-23597-190, a potent 5-hydroxytryptamine4 antagonist labels sigma-1 but not sigma-2 binding sites in guinea pig brain

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5-hydroxytryptamine 2B receptor regulates cell-cycle progression: cross-talk with tyrosine kinase pathways

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Tegaserod-induced myocardial infarction: case report and hypothesis

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Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos immunoreactivity

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Long-term efficacy of oral cisapride in symptomatic upper gut dysmotility.

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Pharmacological characterization of 5-HT4 receptors mediating relaxation of canine isolated rectum circular smooth muscle

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Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats

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Review article: tegaserod

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Tegaserod, a 5-HT(4) receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation

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Nitric oxide is produced via 5-HT1B and 5-HT2B receptor activation in human coronary artery endothelial cells

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Effects of mosapride citrate, a 5-HT4 receptor agonist, on colonic motility in conscious guinea pigs

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5-hydroxytryptamine receptors in the human cardiovascular system

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The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo

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5-HT(2A) receptors: location and functional analysis in intestines of wild-type and 5-HT(2A) knockout mice

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Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts

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Signal transduction pathways for serotonin as an intestinal secretagogue

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5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro

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Unaltered agonist potency upon inducible 5-HT7(a) but not 5-HT4(b) receptor expression indicates agonist-independent association of 5-HT7(a) receptor and Gs.

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Human colonic mucosa possesses a mixed population of 5-HT receptors

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Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain

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Pharmacology and metabolism of renzapride : a novel therapeutic agent for the potential treatment of irritable bowel syndrome

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Evidence for a multivalent interaction of symmetrical, N-linked, lidocaine dimers with voltage-gated Na+ channels.

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Tegaserod, a 5-hydroxytryptamine type 4 receptor partial agonist, is devoid of electrocardiographic effects

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Characterization of human 5-HT4(d) receptor desensitization in CHO cells

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Prucalopride is a partial agonist through human and porcine atrial 5-HT4 receptors: comparison with recombinant human 5-HT4 splice variants

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A highly sensitive adenylate cyclase assay

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12 December 2020

Identification of putative 5-HT4 receptors in guinea-pig ascending colon

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Tegaserod for the treatment of irritable bowel syndrome

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12 December 2020

Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants

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12 December 2020

Treatment of chronic constipation with cisapride and placebo

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12 December 2020

Cisapride in the management of chronic functional dyspepsia: a multicenter, double-blind, placebo-controlled study

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12 December 2020

Tegaserod, a 5-HT4 receptor partial agonist, accelerates gastric emptying and gastrointestinal transit in healthy male subjects

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12 December 2020

Differential functional effects of two 5-HT4 receptor isoforms in adult cardiomyocytes.

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12 December 2020

Desperately seeking serotonin... A commentary on the withdrawal of tegaserod and the state of drug development for functional and motility disorders

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[3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus.

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Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines

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Participation of 5-HT3, 5-HT4, and nicotinic receptors in the peristaltic reflex of guinea pig distal colon

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Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR.

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12 December 2020

Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus

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12 December 2020

Prucalopride is effective in patients with severe chronic constipation in whom laxatives fail to provide adequate relief. Results of a double-blind, placebo-controlled clinical trial

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12 December 2020

The serotonin signaling system: from basic understanding to drug development for functional GI disorders

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12 December 2020

5-Hydroxytryptamine4 receptors mediate relaxation of the rat oesophageal tunica muscularis mucosae

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12 December 2020

Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome

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12 December 2020

The in vivo gastrointestinal activity of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity

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12 December 2020

The action of cisapride on gastric emptying and the pharmacodynamics and pharmacokinetics of oral diazepam

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12 December 2020

5-HT4 receptor activation induces relaxation and associated cAMP generation in rat esophagus

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12 December 2020

5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle

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12 December 2020

Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors.

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12 December 2020

Differential effects of 5-hydroxytryptamine4 receptor agonists at gastric versus cardiac receptors: an operational framework to explain and quantify organ-specific behavior

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12 December 2020

Comparison of 5-HT4 receptors in guinea-pig colon and rat oesophagus: effects of novel agonists and antagonists

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12 December 2020

10.1007/S00210-008-0282-Y

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4 August 2017

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