Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice (Q34150626)

31 July 2017

Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice (English)

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31 July 2017

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Outi M Hyyti

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31 July 2017

Dolena Ledee

2

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31 July 2017

Xue-Han Ning

3

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31 July 2017

Ming Ge

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31 July 2017

Michael A Portman

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31 July 2017

2 July 2010

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American Journal of Physiology Heart and Circulatory Physiology

31 July 2017

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31 July 2017

299

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31 July 2017

H868-75

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31 July 2017

3

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Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha)

31 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944494

Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944494

Superior cardiac function via anaplerotic pyruvate in the immature swine heart after cardiopulmonary bypass and reperfusion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944494

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944494

Cardioselective dominant-negative thyroid hormone receptor (Delta337T) modulates myocardial metabolism and contractile efficiency

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944494

Morphometric changes induced by amino acid supplementation in skeletal and cardiac muscles of old mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944494

Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944494

A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944494

Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944494

Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944494

Response of isolated guinea pig myocardium to insulin therapy during normothermia and graded hypothermia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944494

Fatty acid oxidation by isolated perfused working hearts of aged rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944494

Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle

5 July 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00931.2009

Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00931.2009

Thyroid hormone controls myocardial substrate metabolism through nuclear receptor-mediated and rapid posttranscriptional mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00931.2009

Exercise training improves cardiac function-related gene levels through thyroid hormone receptor signaling in aged rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00931.2009

Impact of aging on substrate metabolism by the human heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00931.2009

Profiling substrate fluxes in the isolated working mouse heart using 13C-labeled substrates: focusing on the origin and fate of pyruvate and citrate carbons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00931.2009

CD36 expression contributes to age-induced cardiomyopathy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00931.2009

Triidothyronine and epinephrine rapidly modify myocardial substrate selection: a (13)C isotopomer analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00931.2009

Effects of chronic activation of peroxisome proliferator-activated receptor-alpha or high-fat feeding in a rat infarct model of heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00931.2009

Metabolic remodeling in the aging heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00931.2009

Influence of perfusate calcium concentration on the inotropic insulin effect in isolated guinea pig and rat hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00931.2009

Mitochondrial metabolism and substrate competition in the aging Fischer rat heart

21 January 2018

1 reference

12 December 2020

Contribution of various substrates to total citric acid cycle flux and anaplerosis as determined by 13C isotopomer analysis and O2 consumption in the heart

1 reference

12 December 2020

The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart

1 reference

12 December 2020

Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts

1 reference

12 December 2020

Long-Term Effects of Increased Glucose Entry on Mouse Hearts During Normal Aging and Ischemic Stress

1 reference

12 December 2020

Assessment of cardiac function with the pressure-volume conductance system following myocardial infarction in mice

1 reference

12 December 2020

Aging is associated with myocardial insulin resistance and mitochondrial dysfunction

1 reference

12 December 2020

Peroxisome proliferator-activated receptor alpha down-regulation is associated with enhanced ceramide levels in age-associated cardiac hypertrophy

1 reference

12 December 2020

10.1152/AJPHEART.00931.2009

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DOI

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31 July 2017

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31 July 2017

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