Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein (Q29618253)

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1853200

30 April 2017

Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein (English)

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

ribonucleoprotein complex

10 December 2022

main subject

spliceosome

0 references

1 reference

1 reference

Europe PubMed Central

PubMed publication ID

1853200

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1853200

10 December 2022

author name string

C. Guthrie

1

1 reference

Europe PubMed Central

PubMed publication ID

1853200

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1853200

10 December 2022

publication date

12 July 1991

1 reference

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1853200

30 April 2017

language of work or name

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https://syndication.highwire.org/content/doi/10.1126/science.1853200

30 April 2017

work available at URL

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

10 December 2022

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1853200

30 April 2017

volume

253

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1853200

30 April 2017

issue

5016

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30 April 2017

page(s)

157-63

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publication type of scholarly work

30 April 2017

review article

1 reference

Europe PubMed Central

cites work

2

10

6417

1990

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Conservation between yeast and man of a protein associated with U5 small nuclear ribonucleoprotein

10 December 2022

4

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Lethal and temperature-sensitive mutations and their suppressors identify an essential structural element in U2 small nuclear RNA.

10 December 2022

5

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Reverse self-splicing of group II intron RNAs in vitro

10 December 2022

6

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

RNA-binding proteins as developmental regulators

10 December 2022

7

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

10 December 2022

8

9

3710

1989

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Targeted snRNP depletion reveals an additional role for mammalian U1 snRNP in spliceosome assembly

10 December 2022

9

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Spliced segments at the 5′ terminus of adenovirus 2 late mRNA

10 December 2022

10

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly

10 December 2022

11

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Domains of yeast U4 spliceosomal RNA required for PRP4 protein binding, snRNP-snRNP interactions, and pre-mRNA splicing in vivo

10 December 2022

12

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Evidence for the existence of snRNAs U4 and U6 in a single ribonucleoprotein complex and for their association by intermolecular base pairing

10 December 2022

13

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Spliceosomal RNA U6 is remarkably conserved from yeast to mammals

10 December 2022

14

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Splicing a spliceosomal RNA

10 December 2022

15

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

A putative ATP binding protein influences the fidelity of branchpoint recognition in yeast splicing

10 December 2022

16

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Self-splicing of group I introns

10 December 2022

17

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Biological catalysis by RNA.

10 December 2022

18

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein

10 December 2022

19

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

10 December 2022

20

8

2379

1988

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Identification of five putative yeast RNA helicase genes

10 December 2022

21

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

The yeast PRP2 protein, a putative RNA-dependent ATPase, shares extensive sequence homology with two other pre-mRNA splicing factors

10 December 2022

22

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Spliceosome assembly in yeast

10 December 2022

23

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA.

10 December 2022

24

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Requirement of the RNA helicase-like protein PRP22 for release of messenger RNA from spliceosomes

10 December 2022

25

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation

10 December 2022

26

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

PRP5: a helicase-like protein required for mRNA splicing in yeast

10 December 2022

27

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

The product of the PRP4 gene of S. cerevisiae shows homology to beta subunits of G proteins

10 December 2022

28

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Two domains of yeast U6 small nuclear RNA required for both steps of nuclear precursor messenger RNA splicing

10 December 2022

29

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Mutations in a yeast intron demonstrate the importance of specific conserved nucleotides for the two stages of nuclear mRNA splicing

10 December 2022

31

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

10 December 2022

32

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

A mammalian protein of 220 kDa binds pre-mRNAs in the spliceosome: a potential homologue of the yeast PRP8 protein

10 December 2022

33

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

A protein associated with small nuclear ribonucleoprotein particles recognizes the 3' splice site of premessenger RNA

10 December 2022

34

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

10 December 2022

Pre-mRNA splicing

35

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

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Spliceosomal snRNAs

37

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Functional analysis of mutant Xenopus U2 snRNAs

10 December 2022

38

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

U4 and U6 RNAs coexist in a single small nuclear ribonucleoprotein particle

10 December 2022

39

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

A quantitative analysis of the effects of 5′ junction and TACTAAC box mutants and mutant combinations on yeast mRNA splicing

10 December 2022

40

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase

10 December 2022

41

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Interactions of PRP2 protein with pre-mRNA splicing complexes in Saccharomyces cerevisiae

10 December 2022

43

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes

10 December 2022

44

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

The trimethyl-guanosine cap is a nuclear targeting signal for snRNPs

10 December 2022

45

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein

10 December 2022

46

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Are snRNPs involved in splicing?

10 December 2022

48

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Universally conserved and yeast-specific U1 snRNA sequences are important but not essential for U1 snRNP function

10 December 2022

49

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Splicing of yeast nuclear pre-mRNA in vitro requires a functional 40S spliceosome and several extrinsic factors

10 December 2022

50

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

10 December 2022

Birth of the D-E-A-D box

51

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Identification of a yeast snRNP protein and detection of snRNP-snRNP interactions

10 December 2022

52

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

The yeast RNA gene products are essential for mRNA splicing in vitro

10 December 2022

54

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Multiple roles for U6 snRNA in the splicing pathway

10 December 2022

55

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing

10 December 2022

56

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Comparative and functional anatomy of group II catalytic introns—a review

10 December 2022

59

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Integration of group II intron bI1 into a foreign RNA by reversal of the self-splicing reaction in vitro

10 December 2022

60

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Mutations in yeast U5 snRNA alter the specificity of 5' splice-site cleavage

10 December 2022

61

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Molecular consequences of specific intron mutations on yeast mRNA splicing in vivo and in vitro

10 December 2022

62

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Splicing of messenger RNA precursors

10 December 2022

63

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

U2 snRNA sequences that bind U2-specific proteins are dispensable for the function of U2 snRNP in splicing

10 December 2022

64

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

A point mutation in the conserved hexanucleotide at a yeast 5' splice junction uncouples recognition, cleavage, and ligation

10 December 2022

65

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA.

10 December 2022

66

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

A U-rich tract enhances usage of an alternative 3′ splice site in yeast

10 December 2022

67

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes

10 December 2022

69

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome

10 December 2022

70

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Intron sequences involved in lariat formation during pre-mRNA splicing

10 December 2022

72

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

The organization of 3' splice-site sequences in mammalian introns

10 December 2022

73

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

The role of the mammalian branchpoint sequence in pre-mRNA splicing

10 December 2022

74

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

An early hierarchic role of U1 small nuclear ribonucleoprotein in spliceosome assembly.

10 December 2022

76

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Pre-mRNA splicing in yeast

10 December 2022

77

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Role of the 3' splice site consensus sequence in mammalian pre-mRNA splicing

10 December 2022

78

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

A novel role for the 3' region of introns in pre-mRNA splicing of Saccharomyces cerevisiae

10 December 2022

79

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome

10 December 2022

80

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing

10 December 2022

81

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Exon mutations uncouple 5' splice site selection from U1 snRNA pairing

10 December 2022

82

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5' cleavage site.

10 December 2022

83

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs

10 December 2022

84

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

On the origin of RNA splicing and introns

10 December 2022

85

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Splicing of messenger RNA precursors

10 December 2022

86

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Two conserved domains of yeast U2 snRNA are separated by 945 nonessential nucleotides.

10 December 2022

87

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

An essential snRNA from S. cerevisiae has properties predicted for U4, including interaction with a U6-like snRNA

10 December 2022

88

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Pattern of transcription of the homeo gene Hox-3.1 in the mouse embryo

10 December 2022

89

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Saccharomyces cerevisiae has a U1-like small nuclear RNA with unexpected properties

10 December 2022

90

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Scanning from an independently specified branch point defines the 3' splice site of mammalian introns

10 December 2022

91

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Cap-binding proteins of eukaryotic messenger RNA: functions in initiation and control of translation

10 December 2022

92

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

The gene for the U6 small nuclear RNA in fission yeast has an intron

10 December 2022

95

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

A protein that specifically recognizes the 3' splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein

10 December 2022

96

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

EFTu provides an internal kinetic standard for translational accuracy

10 December 2022

97

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Fungal small nuclear ribonucleoproteins share properties with plant and vertebrate U-snRNPs.

10 December 2022

98

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Mutations in conserved intron sequences affect multiple steps in the yeast splicing pathway, particularly assembly of the spliceosome.

10 December 2022

100

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

10 December 2022

102

10

324

1990

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Affinity purification of spliceosomes reveals that the precursor RNA processing protein PRP8, a protein in the U5 small nuclear ribonucleoprotein particle, is a component of yeast spliceosomes

10 December 2022

105

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Nuclear pre-mRNA splicing in yeast

10 December 2022

106

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing.

10 December 2022

107

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

A compensatory base change in U1 snRNA suppresses a 5' splice site mutation

10 December 2022

108

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

A compensatory base change in human U2 snRNA can suppress a branch site mutation

10 December 2022

109

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

UACUAAC is the preferred branch site for mammalian mRNA splicing

10 December 2022

110

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1853200

10 December 2022

Identifiers