Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A. (Q34145357)

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English	Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A.	scientific article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12189142%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12189142%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Mitsunori Fukuda

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12189142%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

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Mitsunori Fukuda

1

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31 July 2017

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19 August 2002

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12 November 2019

Journal of Biological Chemistry

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12 November 2019

277

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12 November 2019

42

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12 November 2019

40118-40124

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12189142%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily.

1 reference

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Rab proteins as membrane organizers

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Ypt and Rab GTPases: insight into functions through novel interactions

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Rab GTPases: specifying and deciphering organelle identity and function

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A genomic perspective on membrane compartment organization.

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Evolution of the Rab family of small GTP-binding proteins

1 reference

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Rab GTPases, intracellular traffic and disease.

1 reference

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Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome

1 reference

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A mutation in Rab27a causes the vesicle transport defects observed in ashen mice

1 reference

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Rab27a: A key to melanosome transport in human melanocytes

1 reference

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Rab27a is required for regulated secretion in cytotoxic T lymphocytes

1 reference

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Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice

1 reference

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Rab27a regulates the peripheral distribution of melanosomes in melanocytes

1 reference

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Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins

1 reference

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21 January 2018

Novel splicing isoforms of synaptotagmin-like proteins 2 and 3: identification of the Slp homology domain

1 reference

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21 January 2018

The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain

1 reference

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21 January 2018

Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains

1 reference

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JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase.

1 reference

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Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells

1 reference

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The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules

1 reference

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The C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205765200

21 January 2018

Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205765200

21 January 2018

Identification of an organelle receptor for myosin-Va

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205765200

21 January 2018

MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205765200

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A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205765200

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Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205765200

21 January 2018

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205765200

21 January 2018

Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va to melanosomes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205765200

21 January 2018

Rab27a is an essential component of melanosome receptor for myosin Va

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205765200

21 January 2018

Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205765200

21 January 2018

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205765200

21 January 2018

Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205765200

21 January 2018

pEF-BOS, a powerful mammalian expression vector

1 reference

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Mechanism of the SDS-resistant synaptotagmin clustering mediated by the cysteine cluster at the interface between the transmembrane and spacer domains.

1 reference

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21 January 2018

Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain.

1 reference

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21 January 2018

Distinct self-oligomerization activities of synaptotagmin family. Unique calcium-dependent oligomerization properties of synaptotagmin VII.

1 reference

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Formation of crystalloid endoplasmic reticulum induced by expression of synaptotagmin lacking the conserved WHXL motif in the C terminus. Structural importance of the WHXL motif in the C2B domain

1 reference

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A novel alternatively spliced variant of synaptotagmin VI lacking a transmembrane domain. Implications for distinct functions of the two isoforms

1 reference

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Phospholipid composition dependence of Ca2+-dependent phospholipid binding to the C2A domain of synaptotagmin IV

1 reference

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21 January 2018

Regulation by bivalent cations of phospholipid binding to the C2A domain of synaptotagmin III.

1 reference

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EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205765200

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Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger

1 reference

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EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

1 reference

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FYVE fingers bind PtdIns(3)P

1 reference

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Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains

1 reference

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Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants partially related through N-terminal alpha -helix motifs

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Rab3a binding and secretion-enhancing domains in Rim1 are separate and unique. Studies in adrenal chromaffin cells

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Phosphatidylinositol 3-Phosphate Recognition by the FYVE Domain

1 reference

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