The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2 (Q34107535)

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English	The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2	scientific article

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scholarly article

1 reference

Europe PubMed Central

31 July 2017

The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2 (English)

1 reference

Europe PubMed Central

31 July 2017

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7

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Todd R Golub

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Europe PubMed Central

31 July 2017

author name string

Michael Zimmer

1

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Europe PubMed Central

31 July 2017

Justin Lamb

2

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Europe PubMed Central

31 July 2017

Benjamin L Ebert

3

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Europe PubMed Central

31 July 2017

Mary Lynch

4

1 reference

Europe PubMed Central

31 July 2017

Christopher Neil

5

1 reference

Europe PubMed Central

31 July 2017

Emmett Schmidt

6

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Europe PubMed Central

31 July 2017

Othon Iliopoulos

8

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Europe PubMed Central

31 July 2017

language of work or name

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publication date

30 March 2010

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Europe PubMed Central

31 July 2017

Cancer Research

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Europe PubMed Central

31 July 2017

70

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31 July 2017

8

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Europe PubMed Central

31 July 2017

3071-3079

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Europe PubMed Central

31 July 2017

15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation.

1 reference

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Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing

1 reference

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Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2.

1 reference

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5 July 2018

NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha

1 reference

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5 July 2018

Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861799

5 July 2018

Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861799

5 July 2018

Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency

1 reference

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Molecular biology of renal cell cancer and the identification of therapeutic targets

1 reference

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5 July 2018

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861799

5 July 2018

15-deoxy-Delta12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors

1 reference

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5 July 2018

The role of iron regulatory proteins in mammalian iron homeostasis and disease

1 reference

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5 July 2018

Activation of RhoB by hypoxia controls hypoxia-inducible factor-1alpha stabilization through glycogen synthase kinase-3 in U87 glioblastoma cells

1 reference

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5 July 2018

hnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation

1 reference

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5 July 2018

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

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5 July 2018

Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861799

5 July 2018

Iron metabolism and the IRE/IRP regulatory system: an update

1 reference

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5 July 2018

A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A

1 reference

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5 July 2018

Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.

1 reference

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5 July 2018

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

1 reference

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HIF-1 as a target for drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861799

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Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma

1 reference

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5 July 2018

HIF-1alpha is essential for myeloid cell-mediated inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861799

5 July 2018

Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line

1 reference

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The prolyl 4-hydroxylase inhibitor ethyl-3,4-dihydroxybenzoate generates effective iron deficiency in cultured cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861799

5 July 2018

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861799

5 July 2018

Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861799

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Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice

1 reference

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Inhibition of VEGF expression by targeting HIF-1 alpha with small interference RNA in human RPE cells

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28 October 2018

Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice.

1 reference

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Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade

1 reference

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

1 reference

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Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1

1 reference

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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

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Loops and bulge/loops in iron-responsive element isoforms influence iron regulatory protein binding. Fine-tuning of mRNA regulation?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2861799

28 October 2018

Inducible cyclooxygenase-derived 15-deoxyΔ12-14PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20354189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron deficiency and neutrophil function: different rates of correction of the depressions in oxidative burst and myeloperoxidase activity after iron treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/20354189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron and inflammation: cross-talk between pathways regulating hepcidin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20354189

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-09-2877

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

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