The role of NF-kappaB/IkappaB proteins in cancer: implications for novel treatment strategies (Q34102964)

31 July 2017

1 reference

title

The role of NF-kappaB/IkappaB proteins in cancer: implications for novel treatment strategies (English)

1 reference

31 July 2017

0 references

Schwartz SA

1

1 reference

PubMed ID

11113665

31 July 2017

Hernandez A

series ordinal

2

1 reference

PubMed ID

11113665

31 July 2017

Mark Evers B

series ordinal

3

1 reference

31 July 2017

1 November 1999

1 reference

31 July 2017

1 reference

31 July 2017

8

1 reference

31 July 2017

3

1 reference

31 July 2017

143-153

1 reference

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Multiple signals converging on NF-kappaB.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

NF-kappa B: ten years after

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

The NF-kappa B and I kappa B proteins: new discoveries and insights

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Signal transduction through NF-kappa B.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Modulation of NF-kappa B, and Bcl-2 in apoptosis induced by cisplatin in HeLa cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Nuclear factor - kappaB-dependent regulation of p53 gene expression induced by daunomycin genotoxic drug

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Induction of nuclear factor kappa B after low-dose ionizing radiation involves a reactive oxygen intermediate signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Rel/NF-kappa B and I kappa B factors in oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Clinically relevant findings

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Identification and characterization of an IkappaB kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

IkappaB alpha overexpression in human breast carcinoma MCF7 cells inhibits nuclear factor-kappaB activation but not tumor necrosis factor-alpha-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Efficient adenoviral transfer of NF-kappaB inhibitor sensitizes melanoma to tumor necrosis factor-mediated apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Induction of apoptosis with I-kappaB, the inhibitor of NF-kappaB.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Regulation of NF-kappaB activity by I kappaB-related proteins in adenocarcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated IkappaBalpha overexpression

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

The NF-kappa B transcription factor and cancer: high expression of NF-kappa B- and I kappa B-related proteins in tumor cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Interleukin-1 increases expression of the LYT-10 (NFkappaB2) proto-oncogene/transcription factor in renal cell carcinoma lines

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

A novel NF-kappa B p65 spliced transcript lacking exons 6 and 7 in a non-small cell lung carcinoma cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Innovative treatment programs against cancer: II. Nuclear factor-kappaB (NF-kappaB) as a molecular target

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Biological and biochemical inhibitors of the NF-kappa B/Rel proteins and cytokine synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Inhibition of nuclear factor-kappaB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Enhanced radiosensitivity by inhibition of nuclear factor kappa B activation in human malignant glioma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Intratumoral injection of oligonucleotides to the NF kappa B binding site inhibits cachexia in a mouse tumor model

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Degradation of E2A proteins through a ubiquitin-conjugating enzyme, UbcE2A

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Proteasome-dependent regulation of p21WAF1/CIP1 expression

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Induction of apoptosis by thiuramdisulfides, the reactive metabolites of dithiocarbamates, through coordinative modulation of NFkappaB, c-fos/c-jun, and p53 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Salicylates inhibit NF-kappaB activation and enhance TNF-alpha-induced apoptosis in human pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Sulindac inhibits activation of the NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0960-7404%2800%2900012-8

7 January 2021

10.1016/S0960-7404(00)00012-8

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11113665