Studying human neurodegenerative diseases in flies and worms (Q34083380)

30 July 2017

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title

Studying human neurodegenerative diseases in flies and worms (English)

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30 July 2017

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Feany MB

1

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PubMed ID

11079774

30 July 2017

language of work or name

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1 October 2000

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Journal of Neuropathology & Experimental Neurology

30 July 2017

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30 July 2017

59

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30 July 2017

10

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30 July 2017

847-856

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Comparative genomics of the eukaryotes

30 July 2017

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

A Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Transgenic mice in the study of polyglutamine repeat expansion diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Genetic suppression of polyglutamine toxicity in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Polyglutamine diseases: protein cleavage and aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

A familial Alzheimer's disease locus on chromosome 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Notch1 is essential for postimplantation development in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Alzheimer's disease: clues from flies and worms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

A point mutation of the rhodopsin gene in one form of retinitis pigmentosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Rhodopsin activation causes retinal degeneration in Drosophila rdgC mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

The master control gene for morphogenesis and evolution of the eye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Phenotypic rescue by a bovine transgene in a Cu/Zn superoxide dismutase-null mutant of Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Aging and resistance to oxidative damage in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Subunit-destabilizing mutations in Drosophila copper/zinc superoxide dismutase: neuropathology and a model of dimer dysequilibrium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Expression of human FALS SOD in motorneurons of Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Expression and targeting of Syrian hamster prion protein induced by heat shock in transgenic Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Preventing neurodegeneration in the Drosophila mutant bubblegum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

Defective glia in the Drosophila brain degeneration mutant drop-dead

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNEN%2F59.10.847

21 January 2018

Identifiers

DOI

10.1093/JNEN/59.10.847

1 reference

30 July 2017

1 reference

PubMed ID

11079774