Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo (Q34069534)

30 July 2017

Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo (English)

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30 July 2017

Michael S Hershfield

1

1 reference

30 July 2017

L Jackson Roberts

2

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30 July 2017

Nancy J Ganson

3

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30 July 2017

Susan J Kelly

4

1 reference

30 July 2017

Ines Santisteban

5

1 reference

30 July 2017

Edna Scarlett

6

1 reference

30 July 2017

Denise Jaggers

7

1 reference

30 July 2017

John S Sundy

8

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30 July 2017

language of work or name

English

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publication date

26 July 2010

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Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

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30 July 2017

107

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30 July 2017

32

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30 July 2017

14351-14356

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Boosting endogenous neuroprotection in multiple sclerosis: the ASsociation of Inosine and Interferon beta in relapsing- remitting Multiple Sclerosis (ASIIMS) trial

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Urate as a predictor of the rate of clinical decline in Parkinson disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Gout. Novel therapies for treatment of gout and hyperuricemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Reassessing serum urate targets in the management of refractory gout: can you go too low?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Plasma urate and Parkinson's disease in the Atherosclerosis Risk in Communities (ARIC) study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Reactions of peroxynitrite with uric acid: formation of reactive intermediates, alkylated products and triuret, and in vivo production of triuret under conditions of oxidative stress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Developments in the scientific and clinical understanding of gout

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Long-term cardiovascular mortality among middle-aged men with gout

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Peroxiredoxin 2 and peroxide metabolism in the erythrocyte.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline level

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Lowering serum uric acid levels: what is the optimal target for improving clinical outcomes in gout?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Uric acid, the metabolic syndrome, and renal disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Uric acid in multiple sclerosis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Gout-associated uric acid crystals activate the NALP3 inflammasome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Recent advances in the epidemiology of gout

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Carbonyl modified proteins in cellular regulation, aging, and disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Microdialytical monitoring of uric and ascorbic acids in the brains of patients after severe brain injury and during neurovascular surgery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Total antioxidant capacity as a tool to assess redox status: critical view and experimental data.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Uric acid oxidation by peroxynitrite: multiple reactions, free radical formation, and amplification of lipid oxidation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Hyperuricemia and urate nephropathy in urate oxidase-deficient mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Erythrocyte catalase. A somatic oxidant defense?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Human red cells scavenge extracellular hydrogen peroxide and inhibit formation of hypochlorous acid and hydroxyl radical

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Ascorbate is an outstanding antioxidant in human blood plasma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Two independent mutational events in the loss of urate oxidase during hominoid evolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922538

Spectroscopic characterization of intermediates in the urate oxidase reaction.

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001072107

Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system (PreCIS) database cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001072107

Reduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout: results of a phase II randomized study

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001072107

The peroxidase and peroxynitrite reductase activity of human erythrocyte peroxiredoxin 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001072107

Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001072107

Increased thrombin-induced polymerization of fibrinogen associated with high protein carbonyl levels in plasma from patients post myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001072107

Total antioxidant status at high altitude in lowlanders and native highlanders: role of uric acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001072107

Serum uric acid levels in patients with Parkinson's disease: their relationship to treatment and disease duration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001072107

The urate and xanthine concentrations in the cerebrospinal fluid in patients with vascular dementia of the Binswanger type, Alzheimer type dementia, and Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001072107

A reassessment of the peroxynitrite scavenging activity of uric acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001072107

Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001072107

Resolution of gouty tophi after twelve weeks of pegloticase treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001072107

Prospects for the treatment of multiple sclerosis by raising serum levels of uric acid, a scavenger of peroxynitrite

21 January 2018

1 reference

12 December 2020

Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population

1 reference

12 December 2020

Prevalence of the metabolic syndrome in patients with gout: the Third National Health and Nutrition Examination Survey

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout

1 reference

12 December 2020

Independent impact of gout on mortality and risk for coronary heart disease

1 reference

12 December 2020

Serum Uric Acid and Risk of Cardiovascular Mortality: A Prospective Long-Term Study of 83 683 Austrian Men

1 reference

12 December 2020

Serum uric acid levels correlate with plasma hydrogen peroxide and protein carbonyl levels in preeclampsia

1 reference

12 December 2020

Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage

1 reference

12 December 2020

Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress

1 reference

12 December 2020

Reaction of uric acid with peroxynitrite and implications for the mechanism of neuroprotection by uric acid

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1001072107

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30 July 2017

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30 July 2017

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