SA-4-1BBL as the immunomodulatory component of a HPV-16 E7 protein based vaccine shows robust therapeutic efficacy in a mouse cervical cancer model. (Q34065110)

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English	SA-4-1BBL as the immunomodulatory component of a HPV-16 E7 protein based vaccine shows robust therapeutic efficacy in a mouse cervical cancer model.	scientific article

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7 February 2020

SA-4-1BBL as the immunomodulatory component of a HPV-16 E7 protein based vaccine shows robust therapeutic efficacy in a mouse cervical cancer model (English)

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7 February 2020

cervix uterine cancer

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Shravan Madireddi

6

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7 February 2020

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Rajesh K Sharma

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7 February 2020

Abhishek K Srivastava

2

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7 February 2020

Esma S Yolcu

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7 February 2020

Kathryn J MacLeod

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7 February 2020

Rich-Henry Schabowsky

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7 February 2020

Haval Shirwan

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4 July 2010

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7 February 2020

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7 February 2020

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7 February 2020

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7 February 2020

5794-5802

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7 February 2020

A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicity

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5 July 2018

Hypercostimulation through 4-1BB distorts homeostasis of immune cells

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Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand eradicates established tumors

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5 July 2018

Induction of antitumor immunity in vivo following delivery of a novel HPV-16 DNA vaccine encoding an E6/E7 fusion antigen

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Combined mobilization and stimulation of tumor-infiltrating dendritic cells and natural killer cells with Flt3 ligand and IL-18 in vivo induces systemic antitumor immunity

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Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

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5 July 2018

CD4+CD25+ T regulatory cells dominate multiple immune evasion mechanisms in early but not late phases of tumor development in a B cell lymphoma model

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Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice

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Ectopic expression of vascular cell adhesion molecule-1 as a new mechanism for tumor immune evasion

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Type, density, and location of immune cells within human colorectal tumors predict clinical outcome

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In vivo rescue of defective memory CD8+ T cells by cognate helper T cells

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5 July 2018

TNF/TNFR family members in costimulation of T cell responses

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5 July 2018

Cancer vaccines: between the idea and the reality

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5 July 2018

Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

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5 July 2018

Both E7 and CpG-oligodeoxynucleotide are required for protective immunity against challenge with human papillomavirus 16 (E6/E7) immortalized tumor cells: involvement of CD4+ and CD8+ T cells in protection.

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5 July 2018

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

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Biological activities and molecular targets of the human papillomavirus E7 oncoprotein

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Two Listeria monocytogenes vaccine vectors that express different molecular forms of human papilloma virus-16 (HPV-16) E7 induce qualitatively different T cell immunity that correlates with their ability to induce regression of established tumors im

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5 July 2018

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

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5 July 2018

NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies.

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Metastatic conversion of cells by expression of human papillomavirus type 16 E6 and E7 genes

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5 July 2018

Differential costimulation through CD137 (4-1BB) restores proliferation of human virus-specific "effector memory" (CD28(-) CD45RA(HI)) CD8(+) T cells

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IL-15-dependent induction of 4-1BB promotes antigen-independent CD8 memory T cell survival.

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28 October 2018

NK and CD8+ T cell-mediated eradication of poorly immunogenic B16-F10 melanoma by the combined action of IL-12 gene therapy and 4-1BB costimulation

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Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection

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Association of papillomavirus with cancers of the head and neck

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Human papillomavirus vaccines

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Antibodies against the human papillomavirus type 16 early proteins in human sera: correlation of anti-E7 reactivity with cervical cancer

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Liposome-polycation-DNA (LPD) particle as a carrier and adjuvant for protein-based vaccines: therapeutic effect against cervical cancer

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Ex vivo expansion of CD4+CD25+FoxP3+ T regulatory cells based on synergy between IL-2 and 4-1BB signaling

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Vaccination with an adenoviral vector expressing calreticulin-human papillomavirus 16 E7 fusion protein eradicates E7 expressing established tumors in mice

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Immunohistochemical correlates of response to recombinant interleukin-2-based immunotherapy in humans

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based on heuristic

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Transgenic mice expressing targeted HPV-18 E6 and E7 oncogenes in the epidermis develop verrucous lesions and spontaneous, rasHa-activated papillomas

1 reference

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12 December 2020

based on heuristic

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10.1016/J.VACCINE.2010.06.073

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7 February 2020

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7 February 2020

1 reference

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7 February 2020

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