TAp63 induces senescence and suppresses tumorigenesis in vivo (Q34060915)

30 July 2017

TAp63 induces senescence and suppresses tumorigenesis in vivo (English)

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30 July 2017

William M Keyes

2

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Johannes Zuber

object named as

Johannes Zuber

4

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author name string

Xuecui Guo

1

1 reference

30 July 2017

Cristian Papazoglu

3

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30 July 2017

Wangzhi Li

5

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30 July 2017

Scott W Lowe

6

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30 July 2017

Hannes Vogel

7

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30 July 2017

Alea A Mills

8

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30 July 2017

8 November 2009

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30 July 2017

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30 July 2017

11

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12

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30 July 2017

1451-1457

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https://scigraph.springernature.com/pub.10.1038/ncb1988

30 July 2017

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cites work

TAp63 prevents premature aging by promoting adult stem cell maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

SCF TrCP1 activates and ubiquitylates TAp63gamma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

p63 deficiency activates a program of cellular senescence and leads to accelerated aging

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

The RB and p53 pathways in cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

Oncogenic ras and p53 cooperate to induce cellular senescence

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

Down-regulation of p63 is required for epidermal UV-B-induced apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

AIS is an oncogene amplified in squamous cell carcinoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

Mutational analysis of p51A/TAp63gamma, a p53 homolog, in non-small cell lung cancer and breast cancer.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

p63 is a p53 homologue required for limb and epidermal morphogenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

p53 mutations in human cancers

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

p63 protects the female germ line during meiotic arrest

28 July 2018

1 reference

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

1 reference

Restoration of p53 function leads to tumour regression in vivo

21 January 2018

1 reference

p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.

21 January 2018

1 reference

Phosphorylation and stabilization of TAp63gamma by IkappaB kinase-beta

21 January 2018

1 reference

A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo.

21 January 2018

1 reference

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

21 January 2018

1 reference

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

1 reference

CHD5 is a tumor suppressor at human 1p36

21 January 2018

1 reference

Target gene specificity of E2F and pocket protein family members in living cells

21 January 2018

1 reference

p63 and p73: roles in development and tumor formation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920298

28 October 2018

Senescence comes of age

1 reference

DeltaNp63 induces beta-catenin nuclear accumulation and signaling

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19898465

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19898465

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCB1988

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference

30 July 2017

1 reference