Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin (Q34049823)

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English	Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin	scientific article

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin (English)

1 reference

Europe PubMed Central

30 July 2017

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author name string

J F Westphal

1

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Europe PubMed Central

30 July 2017

language of work or name

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publication date

1 October 2000

1 reference

Europe PubMed Central

30 July 2017

British Journal of Clinical Pharmacology

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Europe PubMed Central

30 July 2017

50

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Europe PubMed Central

30 July 2017

4

1 reference

Europe PubMed Central

30 July 2017

285-295

1 reference

Europe PubMed Central

30 July 2017

Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Decreased antipyrine clearance following endotoxin administration: in vivo evidence of the role of nitric oxide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Intravenous azithromycin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Torsade de pointes induced by cisapride/clarithromycin interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

The influence of cisapride and clarithromycin on QT intervals in healthy volunteers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Effect of clarithromycin on renal excretion of digoxin: interaction with P-glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Steady-state pharmacokinetics and electrocardiographic pharmacodynamics of clarithromycin and loratadine after individual or concomitant administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

The mechanism of cyclosporine toxicity induced by clarithromycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Drug interactions of macrolides: emphasis on dirithromycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Human P450 metabolism of warfarin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Interaction between midazolam and clarithromycin: comparison with azithromycin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Metabolism of drugs by cytochrome P450 3A isoforms. Implications for drug interactions in psychopharmacology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Theophylline metabolism in human liver microsomes: inhibition studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

A kinetic and dynamic study of oral alprazolam with and without erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in alprazolam metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Erythromycin-induced clozapine toxic reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Macrolides versus azalides: a drug interaction update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Cytochrome P-450 complex formation by dirithromycin and other macrolides in rat and human livers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Clinical pharmacokinetics of newer antibacterial agents in liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Erythromycin-associated ergotamine intoxication: arteriographic and electrophysiologic analysis of a rare cause of severe ischemia of the lower extremities and associated ischemic neuropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Digoxin-cyclosporin A interaction: modulation of the multidrug transporter P-glycoprotein in the kidney

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Hepatic side-effects of antibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Cisapride: a gastrointestinal prokinetic drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Seizure following addition of erythromycin to clozapine treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

A review of clinical trials comparing HMG-CoA reductase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Theophylline N-demethylations as probes for P4501A1 and P4501A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Possible inhibition of hepatic metabolism of quinidine by erythromycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Long QT syndrome during high-dose cisapride

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Recent advances: the cytochrome P450 enzymes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

The fate of naringin in humans: A key to grapefruit juice-drug interactions?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Macrolide antibacterials. Drug interactions of clinical significance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Loratadine administered concomitantly with erythromycin: pharmacokinetic and electrocardiographic evaluations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

The effect of erythromycin on the disposition kinetics of warfarin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Antipyrine clearance in pneumonia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Inhibition by erythromycin of the conversion of carbamazepine to its active 10,11-epoxide metabolite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Erythromycin enhances the absorption of cyclosporin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Effect of erythromycin in patients receiving long-term warfarin therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Reversal of drug resistance by erythromycin: erythromycin increases the accumulation of actinomycin D and doxorubicin in multidrug-resistant cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Potentially fatal interaction between erythromycin and disopyramide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Pharmacokinetic drug interactions with cyclosporin (Part I).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Polymorphisms in oxidative drug metabolism: relationship to food preference

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Drug metabolism by cytochromes P450 in the liver and small bowel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Pharmacokinetic drug interactions of macrolides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Cyclosporin metabolism by human gastrointestinal mucosal microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Characterization of human liver cytochromes P-450 involved in theophylline metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Age as a determinant of sensitivity to warfarin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

5 July 2018

Inhibition of theophylline metabolism by interferon

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2000.00261.X

21 January 2018

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2000.00261.X

21 January 2018

A potentially hazardous interaction between erythromycin and midazolam.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2000.00261.X

21 January 2018

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2000.00261.X

21 January 2018

Concomitant digoxin toxicity and warfarin interaction in a patient receiving clarithromycin.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2000.00261.X

21 January 2018

Potential interaction between clarithromycin and warfarin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

28 October 2018

Clinical ergotism with lingual ischemia induced by clarithromycin-ergotamine interaction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

28 October 2018

Human P-glycoprotein transports cyclosporin A and FK506.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2015000

28 October 2018

Drug interactions and hepatitis produced by some macrolide antibiotics

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2000.00261.X

21 January 2018

Decreased intestinal CYP3A in celiac disease: Reversal after successful gluten-free diet: A potential source of interindividual variability in first-pass drug metabolism*

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2125.2000.00261.X

21 January 2018

Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation*

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

QT interval prolongation and torsades de pointes due to erythromycin lactobionate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From the Food and Drug Administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cisapride and fatal arrhythmia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Influence of Dirithromycin on the Pharmacokinetics of Cyclosporine in Healthy Subjects and in Renal Transplant Patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Life-threatening interaction between clarithromycin and disopyramide

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced serum theophylline concentrations after discontinuation of azithromycin: evidence for an unusual interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible increased anticoagulation effect of warfarin induced by azithromycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Steady-state pharmacokinetics of theophylline in COPD patients treated with dirithromycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between tacrolimus and erythromycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased hypoprothrombinemic effect of warfarin possibly induced by azithromycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidation of quinidine by human liver cytochrome P-450

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of clarithromycin and its metabolites on the mixed function oxidase system in hepatic microsomes of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible interaction between azithromycin and cyclosporin: a case report

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of terfenadine metabolism. Pharmacokinetic and pharmacodynamic consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of erythromycin on theophylline kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/11012550

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1046/J.1365-2125.2000.00261.X

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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