A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD. (Q34044484)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25053839%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD (English)

1 reference

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10 March 2020

1 reference

1

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10 March 2020

Christoph Josi

2

1 reference

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10 March 2020

author name string

Hitomi Kurosawa

3

1 reference

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10 March 2020

Akio Yamashita

4

1 reference

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10 March 2020

Oliver Mühlemann

5

1 reference

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10 March 2020

language of work or name

English

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publication date

22 July 2014

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10 March 2020

published in

Nucleic Acids Research

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10 March 2020

volume

42

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10 March 2020

page(s)

9217-9235

1 reference

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10 March 2020

issue

14

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Creative Commons Attribution-NonCommercial 4.0 International

10 March 2020

copyright license

start time

4 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6

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Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1.

5 July 2018

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Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways

5 July 2018

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Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay

5 July 2018

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Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains

5 July 2018

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Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

5 July 2018

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SMG5-PNRC2 is functionally dominant compared with SMG5-SMG7 in mammalian nonsense-mediated mRNA decay

5 July 2018

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The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus

5 July 2018

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PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

5 July 2018

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Microscale thermophoresis as a sensitive method to quantify protein: nucleic acid interactions in solution

5 July 2018

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Autoregulation of the nonsense-mediated mRNA decay pathway in human cells

5 July 2018

1 reference

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Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases

5 July 2018

1 reference

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N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

5 July 2018

1 reference

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Mechanisms of endonuclease-mediated mRNA decay

5 July 2018

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Molecular interaction studies using microscale thermophoresis

5 July 2018

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Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2

5 July 2018

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Thermophoretic melting curves quantify the conformation and stability of RNA and DNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Cutting the nonsense: the degradation of PTC-containing mRNAs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

The telomeric transcriptome and SMG proteins at the crossroads.

5 July 2018

1 reference

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SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

5 July 2018

1 reference

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SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

5 July 2018

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A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay

5 July 2018

1 reference

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Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region

5 July 2018

1 reference

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Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

5 July 2018

1 reference

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Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase

5 July 2018

1 reference

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Crystal structure of the PIN domain of human telomerase-associated protein EST1A

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Structural and functional insights into the human Upf1 helicase core

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

The double life of UPF1 in RNA and DNA stability pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Crystallization and preliminary X-ray analysis of the PIN domain of human EST1A

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

SMG7 acts as a molecular link between mRNA surveillance and mRNA decay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Efficient downregulation of immunoglobulin mu mRNA with premature translation-termination codons requires the 5'-half of the VDJ exon

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Nonsense-mediated mRNA decay in health and disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Binary specification of nonsense codons by splicing and cytoplasmic translation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Termination of translation in eukaryotes is governed by two interacting polypeptide chain release factors, eRF1 and eRF3.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

A novel genetic system to detect protein-protein interactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

Improved method for high efficiency transformation of intact yeast cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2.

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKU645

Revealing transient structures of nucleosomes as DNA unwinds.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKU645

Analysis of nonsense-mediated mRNA decay in mammalian cells.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4132754

A highly sensitive and non-lethal beta-galactosidase plate assay for yeast

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25053839

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25053839

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Long-range interactions in nonsense-mediated mRNA decay are mediated by intrinsically disordered protein regions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25053839

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKU645

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25053839%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25053839%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25053839%20AND%20SRC:MED&resulttype=core&format=json