SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells (Q24322693)

Nature Structural & Molecular Biology

GOA release 2020-03-11

3

Oliver Mühlemann

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Torben Heick Jensen

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4

object named as

Torben Heick Jensen

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author name string

Andrea B Eberle

series ordinal

1

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Søren Lykke-Andersen

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2

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language of work or name

English

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publication date

January 2009

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published in

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volume

16

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page(s)

49-55

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issue

1

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cites work

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mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.

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Recognition and elimination of nonsense mRNA.

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Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans

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The meaning of nonsense

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Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast

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Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise

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Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets

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hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay

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Association of yeast Upf1p with direct substrates of the NMD pathway.

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Nonsense-mediated decay approaches the clinic

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A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay

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Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region

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Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay

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A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay

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Binary specification of nonsense codons by splicing and cytoplasmic translation

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Computational modeling and experimental analysis of nonsense-mediated decay in yeast

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Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover

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Premature translational termination triggers mRNA decapping

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Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway

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Premature termination codons enhance mRNA decapping in human cells.

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Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities

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Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover

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Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila

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Nonsense-associated alternative splicing of T-cell receptor beta genes: no evidence for frame dependence

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The RNA exosome component hRrp6 is a target for 5-fluorouracil in human cells

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Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex

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SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

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Endonucleolytic RNA cleavage by a eukaryotic exosome

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The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities.

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Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

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Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

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Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts

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A GFP-based reporter system to monitor nonsense-mediated mRNA decay

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Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

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EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length.

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Cellular mutants define a common mRNA degradation pathway targeting cytokine AU-rich elements

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19060897

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.1530

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

4009730

1020229438

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4009730

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference