The human papillomavirus E6 oncogene represses a cell adhesion pathway and disrupts focal adhesion through degradation of TAp63β upon transformation (Q34042655)

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English	The human papillomavirus E6 oncogene represses a cell adhesion pathway and disrupts focal adhesion through degradation of TAp63β upon transformation	scientific article

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14 February 2020

The human papillomavirus E6 oncogene represses a cell adhesion pathway and disrupts focal adhesion through degradation of TAp63β upon transformation (English)

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14 February 2020

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Youcef Ben Khalifa

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14 February 2020

Sébastien Teissier

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14 February 2020

Meng-Kwang Marcus Tan

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14 February 2020

Quang Tien Phan

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14 February 2020

Wei Qi Wong

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14 February 2020

Françoise Thierry

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29 September 2011

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14 February 2020

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14 February 2020

e1002256

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14 February 2020

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Creative Commons Attribution 4.0 International

29 September 2011

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April 2022 Public Data File from Crossref

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TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

DeltaNp63alpha repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

TAp63 induces senescence and suppresses tumorigenesis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

TAp63 prevents premature aging by promoting adult stem cell maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

The HECT family of E3 ubiquitin ligases: multiple players in cancer development

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5 July 2018

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

1 reference

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5 July 2018

The majority of viral-cellular fusion transcripts in cervical carcinomas cotranscribe cellular sequences of known or predicted genes

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5 July 2018

Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with DeltaNp73.

1 reference

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5 July 2018

A new E6/P63 pathway, together with a strong E7/E2F mitotic pathway, modulates the transcriptome in cervical cancer cells

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5 July 2018

Novel in vivo targets of DeltaNp63 in keratinocytes identified by a modified chromatin immunoprecipitation approach

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5 July 2018

Regulation of Notch1 gene expression by p53 in epithelial cells

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5 July 2018

p63-associated disorders.

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5 July 2018

Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

p63 protects the female germ line during meiotic arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

New p63 targets in keratinocytes identified by a genome-wide approach.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

The E3 ubiquitin ligase Itch controls the protein stability of p63

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

p63 regulates an adhesion programme and cell survival in epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

TA-p63-gamma regulates expression of DeltaN-p63 in a manner that is sensitive to p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

DNA-binding and transactivation activities are essential for TAp63 protein degradation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

DeltaNp63alpha up-regulates the Hsp70 gene in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

p63 expression profiles in human normal and tumor tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

p63 expression is associated with p53 loss in oral-esophageal epithelia of p53-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

Histologic and immunophenotypic classification of cervical carcinomas by expression of the p53 homologue p63: a study of 250 cases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

P63 and P73: P53 mimics, menaces and more

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

p63 is a p53 homologue required for limb and epidermal morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

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5 July 2018

The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.

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5 July 2018

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3182928

5 July 2018

Type-dependent integration frequency of human papillomavirus genomes in cervical lesions.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002256

21 January 2018

A genomic approach reveals a novel mitotic pathway in papillomavirus carcinogenesis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002256

21 January 2018

Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002256

21 January 2018

Regulatory domain of protein stability of human P51/TAP63, a P53 homologue

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002256

21 January 2018

Transcription-independent triggering of the extrinsic pathway of apoptosis by human papillomavirus 18 E2 protein.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002256

21 January 2018

Failure of viral oncoproteins to target the p53-homologue p51A

1 reference

https://pubmed.ncbi.nlm.nih.gov/21980285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63

1 reference

https://pubmed.ncbi.nlm.nih.gov/21980285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PPAT.1002256

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14 February 2020

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Europe PubMed Central

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14 February 2020

1 reference

Europe PubMed Central

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14 February 2020

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