PI3-kinase inhibition: a target for drug development? (Q34011982)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10954868%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

review article

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title

PI3-kinase inhibition: a target for drug development? (English)

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9 November 2019

1

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9 November 2019

author name string

M D Waterfield

series ordinal

2

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9 November 2019

publication date

1 September 2000

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Trends in Molecular Medicine

9 November 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10954868%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

volume

6

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9 November 2019

page(s)

347-357

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9 November 2019

issue

9

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A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

9 November 2019

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p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin

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7 January 2021

Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK

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Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

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Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis

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The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae

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The DNA-dependent protein kinase

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ATM: a mediator of multiple responses to genotoxic stress

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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

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Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

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The PI3K-PDK1 connection: more than just a road to PKB

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The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors

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A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction

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7 January 2021

Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages

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7 January 2021

Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes

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Phosphatidylinositol-3-OH kinases are Rab5 effectors.

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Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

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7 January 2021

Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation

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7 January 2021

PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1.

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7 January 2021

Perspectives: cell biology. All creatures great and small

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7 January 2021

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

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7 January 2021

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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7 January 2021

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

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The catalytic subunit of phosphoinositide 3-kinase: requirements for oncogenicity

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7 January 2021

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

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7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

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7 January 2021

PIK3CA as an oncogene in cervical cancer

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7 January 2021

Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors.

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7 January 2021

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

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Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

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Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

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7 January 2021

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

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PI 3-kinase: a pivotal pathway in T-cell activation?

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A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase.

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Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

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Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

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7 January 2021

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Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

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7 January 2021

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

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7 January 2021

Moving in mysterious ways

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7 January 2021

Structural insights into phosphoinositide 3-kinase catalysis and signalling

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7 January 2021

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

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7 January 2021

10.1016/S1357-4310(00)01770-6

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10954868%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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