A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses (Q33934484)

30 July 2017

title

A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses (English)

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30 July 2017

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Kazu Matsumoto

1

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30 July 2017

Fumitoshi Irie

series ordinal

2

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30 July 2017

Susan Mackem

series ordinal

3

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30 July 2017

Yu Yamaguchi

series ordinal

4

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30 July 2017

language of work or name

English

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publication date

1 June 2010

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Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

published in

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30 July 2017

volume

107

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30 July 2017

issue

24

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30 July 2017

page(s)

10932-10937

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Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects

30 July 2017

cites work

1 reference

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Functional analysis of chick heparan sulfate 6-O-sulfotransferases in limb bud development.

5 July 2018

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Heparan sulfate regulates ephrin-A3/EphA receptor signaling

5 July 2018

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Mechanical regulation of PTHrP expression in entheses

5 July 2018

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Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton

5 July 2018

1 reference

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Mice deficient in Ext2 lack heparan sulfate and develop exostoses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

Manifestations of hereditary multiple exostoses

5 July 2018

1 reference

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Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton

5 July 2018

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Mammalian Brain Morphogenesis and Midline Axon Guidance Require Heparan Sulfate

5 July 2018

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Hereditary multiple exostoses and heparan sulfate polymerization

5 July 2018

1 reference

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Genotype-phenotype correlation in hereditary multiple exostoses

5 July 2018

1 reference

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The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis

5 July 2018

1 reference

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Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

Molecular basis of multiple exostoses: mutations in the EXT1 and EXT2 genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

Generalized lacZ expression with the ROSA26 Cre reporter strain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

Genetic heterogeneity in families with hereditary multiple exostoses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

Loss of heterozygosity in chondrosarcomas for markers linked to hereditary multiple exostoses loci on chromosomes 8 and 11.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

Hereditary multiple exostosis and chondrosarcoma: linkage to chromosome II and loss of heterozygosity for EXT-linked markers on chromosomes II and 8.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

Hereditary multiple exostosis: another etiology of short leg and scoliosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

Hereditary multiple exostoses.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890731

Decreased EXT expression and intracellular accumulation of heparan sulphate proteoglycan in osteochondromas and peripheral chondrosarcomas.

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0914642107

Identification of a stem cell niche in the zone of Ranvier within the knee joint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0914642107

Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0914642107

The Role of EXT1 in Nonhereditary Osteochondroma: Identification of Homozygous Deletions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0914642107

EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development

21 January 2018

1 reference

12 December 2020

Expression of Cre recombinase in the developing mouse limb bud driven by aPrxl enhancer

1 reference

12 December 2020

Reevaluation of a genetic model for the development of exostosis in hereditary multiple exostosis

1 reference

12 December 2020

Management of deformities of the forearm in multiple hereditary osteochondromas

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0914642107

1 reference

30 July 2017

0 references

1 reference

30 July 2017

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