β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome (Q33919634)

30 July 2017

β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome (English)

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30 July 2017

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Nikolaos Mellios

1

1 reference

30 July 2017

Jonathan Woodson

2

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30 July 2017

Rodrigo I Garcia

3

1 reference

30 July 2017

Benjamin Crawford

4

1 reference

30 July 2017

Jitendra Sharma

5

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30 July 2017

Steven D Sheridan

6

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30 July 2017

Stephen J Haggarty

7

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30 July 2017

Mriganka Sur

8

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30 July 2017

language of work or name

English

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publication date

23 June 2014

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Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

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30 July 2017

111

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30 July 2017

9947-9952

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30 July 2017

27

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Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Recent Progress in Rett Syndrome and MeCP2 Dysfunction: Assessment of Potential Treatment Options

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

A descriptive study of adverse events from clenbuterol misuse and abuse for weight loss and bodybuilding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Mechanisms and therapeutic challenges in autism spectrum disorders: insights from Rett syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Preclinical research in Rett syndrome: setting the foundation for translational success.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Female Mecp2(+/-) mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

IGF1 as a Potential Treatment for Rett Syndrome: Safety Assessment in Six Rett Patients

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Clenbuterol upregulates histone demethylase JHDM2a via the β2-adrenoceptor/cAMP/PKA/p-CREB signaling pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

An antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Dual regulation of miRNA biogenesis generates target specificity in neurotrophin-induced protein synthesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Rett syndrome: revised diagnostic criteria and nomenclature

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Epilepsy and the natural history of Rett syndrome.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Pathophysiology of locus ceruleus neurons in a mouse model of Rett syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Mouse models of Rett syndrome: from behavioural phenotyping to preclinical evaluation of new therapeutic approaches

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome--Mecp2 gene dosage effects and BDNF expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

MeCP2 deficiency in the brain decreases BDNF levels by REST/CoREST-mediated repression and increases TRKB production

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

The story of Rett syndrome: from clinic to neurobiology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Behavioral and anatomical abnormalities in Mecp2 mutant mice: a model for Rett syndrome.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Beta2 adrenergic agonist, clenbuterol, enhances working memory performance in aging animals.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Separate respiratory phenotypes in methyl-CpG-binding protein 2 (Mecp2) deficient mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Defect in normal developmental increase of the brain biogenic amine concentrations in the mecp2-null mouse

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Anticonvulsant and sodium channel blocking activity of higher doses of clenbuterol

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Quantitative autoradiography of beta 1- and beta 2-adrenergic receptors in rat brain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Peripheral mediation of effects of clenbuterol on locomotor and investigatory behavior in rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Reduction of biogenic amine levels in the Rett syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

A review of the respiratory disorder in the Rett syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

Cerebellar and cerebral abnormalities in Rett syndrome: a quantitative MR analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103343

The role of different X-inactivation pattern on the variable clinical phenotype with Rett syndrome.

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309426111

The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309426111

The β2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309426111

Activation of β2-adrenoceptor enhances synaptic potentiation and behavioral memory via cAMP-PKA signaling in the medial prefrontal cortex of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309426111

Clenbuterol induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309426111

Epac-mediated cAMP-signalling in the mouse model of Rett Syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309426111

Breathing dysfunctions associated with impaired control of postinspiratory activity in Mecp2-/y knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309426111

Effects of postnatal dietary choline supplementation on motor regional brain volume and growth factor expression in a mouse model of Rett syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309426111

Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309426111

Cholinergic hypofunction in MeCP2-308 mice: beneficial neurobehavioural effects of neonatal choline supplementation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309426111

Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309426111

Comparative signaling pathways of insulin-like growth factor-1 and brain-derived neurotrophic factor in hippocampal neurons and the role of the PI3 kinase pathway in cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1309426111

21 January 2018

Identifiers

DOI

10.1073/PNAS.1309426111

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference