Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies. (Q33914222)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16061794%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

title

Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies (English)

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4 January 2020

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4 January 2020

author name string

Todd W Miller

2

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4 January 2020

Jack M Webster

3

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4 January 2020

James S Huston

4

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4 January 2020

Leslie M Thompson

5

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4 January 2020

J Lawrence Marsh

6

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4 January 2020

Anne Messer

7

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4 January 2020

language of work or name

English

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publication date

1 August 2005

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Proceedings of the National Academy of Sciences of the United States of America

4 January 2020

published in

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4 January 2020

volume

102

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4 January 2020

issue

32

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4 January 2020

page(s)

11563-11568

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A human single-chain Fv intrabody preferentially targets amino-terminal Huntingtin's fragments in striatal models of Huntington's disease

4 January 2020

cites work

1 reference

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Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.

5 July 2018

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Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody

5 July 2018

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A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed alpha-synuclein

5 July 2018

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5 July 2018

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

5 July 2018

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Development of a human light chain variable domain (V(L)) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display

5 July 2018

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Protein aggregation and neurodegenerative disease

5 July 2018

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5 July 2018

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5 July 2018

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

5 July 2018

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Can flies help humans treat neurodegenerative diseases?

5 July 2018

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Experimental therapeutics in transgenic mouse models of Huntington's disease

5 July 2018

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Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments

5 July 2018

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Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

5 July 2018

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Intrabody and intrakine strategies for molecular therapy

5 July 2018

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Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila

5 July 2018

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A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila

5 July 2018

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

5 July 2018

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Dying for a cause: invertebrate genetics takes on human neurodegeneration

5 July 2018

1 reference

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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

5 July 2018

1 reference

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Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library

5 July 2018

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Mouse and fly models of neurodegeneration

5 July 2018

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Lessons from animal models of Huntington's disease

5 July 2018

1 reference

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A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

5 July 2018

1 reference

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Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity

5 July 2018

1 reference

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

5 July 2018

1 reference

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Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease

5 July 2018

1 reference

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A cancer gene therapy approach utilizing an anti-erbB-2 single-chain antibody-encoding adenovirus (AD21): a phase I trial.

5 July 2018

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Genetic suppression of polyglutamine toxicity in Drosophila

5 July 2018

1 reference

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Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila

5 July 2018

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The hormonal coordination of behavior and physiology at adult ecdysis in Drosophila melanogaster.

5 July 2018

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Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

5 July 2018

1 reference

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

5 July 2018

1 reference

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

5 July 2018

1 reference

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5 July 2018

Antibody binding sites

1 reference

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

5 July 2018

1 reference

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

Clinical protocol. Administration of a replication-deficient adeno-associated virus gene transfer vector expressing the human CLN2 cDNA to the brain of children with late infantile neuronal ceroid lipofuscinosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

Inhibition of polyglutamine aggregate cytotoxicity by a structure-based elongation inhibitor

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

A single-chain Fv intrabody provides functional protection against the effects of mutant protein in an organotypic slice culture model of Huntington's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

A Rapid Cellular FRET Assay of Polyglutamine Aggregation Identifies a Novel Inhibitor

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

Human neurodegenerative disease modeling using Drosophila.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

Gene transfer methods for CNS organotypic cultures: a comparison of three nonviral methods.

29 October 2018

1 reference

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Identification of genes that modify ataxin-1-induced neurodegeneration.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1183604

29 October 2018

Identifiers

DOI

10.1073/PNAS.0505321102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16061794%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

0 references

1 reference

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4 January 2020

1 reference