Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA. (Q33912006)

30 July 2017

Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA. (English)

1 reference

30 July 2017

N Zambrano

4

0 references

Rodney E. Harrington

8

object named as

R E Harrington

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author name string

P Balagurumoorthy

1

1 reference

30 July 2017

H Sakamoto

2

1 reference

30 July 2017

M S Lewis

3

1 reference

30 July 2017

G M Clore

5

1 reference

30 July 2017

A M Gronenborn

6

1 reference

30 July 2017

E Appella

7

1 reference

30 July 2017

language of work or name

English

0 references

publication date

1 September 1995

1 reference

Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

1 reference

30 July 2017

92

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30 July 2017

19

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30 July 2017

8591-8595

1 reference

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Studies of DNA bending and flexibility using gel electrophoresis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

The tumor suppressor genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

WAF1, a potential mediator of p53 tumor suppression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Transcriptional activation: a complex puzzle with few easy pieces

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Specific sequences from the carboxyl terminus of human p53 gene product form anti-parallel tetramers in solution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

How loops, beta sheets, and alpha helices help us to understand p53.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

High-resolution structure of the oligomerization domain of p53 by multidimensional NMR

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Cell cycle control and cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Interaction of the DNA-binding domain of Drosophila heat shock factor with its cognate DNA site: a thermodynamic analysis using analytical ultracentrifugation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Interaction of p53 with its consensus DNA-binding site

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

p53 tagged sites from human genomic DNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

p53 oligomerization and DNA looping are linked with transcriptional activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Solution structure of the tetrameric minimum transforming domain of p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Giant leap for p53, small step for drug design

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Direct evidence for DNA bending at the lambda replication origin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Structural studies of protein-nucleic acid interaction: the sources of sequence-specific binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

DNA bending induced by Cro protein binding as demonstrated by gel electrophoresis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

p53 mutations in human cancers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Cancer. p53, guardian of the genome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

A transcriptionally active DNA-binding site for human p53 protein complexes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

DNA curving and bending in protein-DNA recognition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Protein-induced bending and DNA cyclization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

Definition of a consensus binding site for p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

DNA bending by Cro protein in specific and nonspecific complexes: implications for protein site recognition and specificity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41012

The p53 tumor suppressor protein: meeting review

29 October 2018

1 reference

12 December 2020

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

1 reference

12 December 2020

Physiological concentration of magnesium ions induces a strong macroscopic curvature in GGGCCC-containing DNA

1 reference

12 December 2020

Forms and functions of p53

1 reference

12 December 2020

Structural and kinetic analysis of p53-DNA complexes and comparison of human and murine p53

1 reference

12 December 2020

Interhelical angles in the solution structure of the oligomerization domain of p53: correction

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.92.19.8591

1 reference

release_li4u7wqm65avzkbhnqyerevrwy

30 July 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/li4u7wqm65avzkbhnqyerevrwy

24 November 2022

mapped directly with Wikidata item

PMCID

41012

1 reference

30 July 2017

1 reference