Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo. (Q33898950)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10781403%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

review article

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title

Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10781403%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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1

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6 November 2019

Mark J. Smyth

series ordinal

4

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6 November 2019

author name string

J Davis

series ordinal

2

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6 November 2019

V R Sutton

series ordinal

3

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6 November 2019

publication date

1 June 2000

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Current Opinion in Immunology

6 November 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10781403%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

volume

12

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6 November 2019

issue

3

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6 November 2019

page(s)

323-329

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

6 November 2019

cites work

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7 January 2021

Dual mechanisms of apoptosis induction by cytotoxic lymphocytes.

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7 January 2021

Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

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7 January 2021

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

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7 January 2021

Perforin-mediated myocardial damage in acute myocarditis

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A natural killer cell granule protein that induces DNA fragmentation and apoptosis

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Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

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7 January 2021

Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

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7 January 2021

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

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7 January 2021

Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction

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7 January 2021

Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

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7 January 2021

An antimicrobial activity of cytolytic T cells mediated by granulysin

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7 January 2021

CTL granules: evolution of vesicles essential for combating virus infections

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7 January 2021

Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases

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7 January 2021

Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

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7 January 2021

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

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7 January 2021

Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

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7 January 2021

The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity

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7 January 2021

Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis

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7 January 2021

BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis

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7 January 2021

The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes

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7 January 2021

Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

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7 January 2021

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

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7 January 2021

Perforin is essential for control of ectromelia virus but not related poxviruses in mice.

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7 January 2021

Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

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7 January 2021

The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)

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7 January 2021

A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes

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7 January 2021

The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

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7 January 2021

Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells

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7 January 2021

Homeostatic regulation of CD8+ T cells by perforin

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7 January 2021

Aplastic anemia rescued by exhaustion of cytokine-secreting CD8+ T cells in persistent infection with lymphocytic choriomeningitis virus

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7 January 2021

Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

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7 January 2021

Decreased tumor surveillance in perforin-deficient mice

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7 January 2021

Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12

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7 January 2021

Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein

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7 January 2021

Fas ligand: a sensor for DNA damage critical in skin cancer etiology

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7 January 2021

10.1016/S0952-7915(00)00094-7

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10781403%20AND%20SRC:MED&resulttype=core&format=json

release_ngdq5hbm7nba5lshgrci36r2ee

6 November 2019

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/ngdq5hbm7nba5lshgrci36r2ee

24 November 2022

mapped directly with Wikidata item

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