Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel (Q33882532)

29 July 2017

Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel (English)

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cryogenic electron microscopy

29 July 2017

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3

Roderick MacKinnon

1 reference

29 July 2017

Xiao Tao

1

1 reference

29 July 2017

Richard K Hite

series ordinal

2

1 reference

29 July 2017

language of work or name

English

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publication date

14 December 2016

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29 July 2017

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29 July 2017

541

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29 July 2017

46-51

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29 July 2017

7635

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https://scigraph.springernature.com/pub.10.1038/nature20608

29 July 2017

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cites work

High resolution single particle refinement in EMAN2.1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Alignment of cryo-EM movies of individual particles by optimization of image translations.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

A robust pipeline for rapid production of versatile nanobody repertoires

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Quantifying the local resolution of cryo-EM density maps

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Properties of Slo1 K+ channels with and without the gating ring

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Collaboration gets the most out of software

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

A BK (Slo1) channel journey from molecule to physiology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Likelihood-based classification of cryo-EM images using FREALIGN

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

RELION: implementation of a Bayesian approach to cryo-EM structure determination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Mechanism of voltage gating in potassium channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

The Phenix software for automated determination of macromolecular structures

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Ion sensing in the RCK1 domain of BK channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Location of modulatory beta subunits in BK potassium channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Features and development of Coot

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

A Gating Charge Transfer Center in Voltage Sensors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

A carboxy-terminal affinity tag for the purification and mass spectrometric characterization of integral membrane proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Identification of new, well-populated amino-acid sidechain rotamers involving hydroxyl-hydrogen atoms and sulfhydryl-hydrogen atoms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Measurements of the BKCa channel's high-affinity Ca2+ binding constants: effects of membrane voltage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Intra- and intersubunit cooperativity in activation of BK channels by Ca2+

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Automated electron microscope tomography using robust prediction of specimen movements

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

The appearance of a protein kinase A-regulated splice isoform of slo is associated with the maturation of neurons that control reproductive behavior

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

UCSF Chimera--a visualization system for exploratory research and analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Unique inner pore properties of BK channels revealed by quaternary ammonium block

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

The Occupancy of Ions in the K+ Selectivity Filter: Charge Balance and Coupling of Ion Binding to a Protein Conformational Change Underlie High Conduction Rates

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy

5 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

5 July 2018

https://api.crossref.org/works/10.1038%2FNATURE20608

7 January 2021

A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensitivity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

A novel calcium-sensing domain in the BK channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Voltage-controlled gating in a large conductance Ca2+-sensitive K+channel (hslo).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Total charge movement per channel. The relation between gating charge displacement and the voltage sensitivity of activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Effective gating charges per channel in voltage-dependent K+ and Ca2+ channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Transfer of twelve charges is needed to open skeletal muscle Na+ channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Contribution of the S4 segment to gating charge in the Shaker K+ channel.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Voltage-dependent gating of ionic channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Reconstitution in planar lipid bilayers of a Ca2+-dependent K+ channel from transverse tubule membranes isolated from rabbit skeletal muscle

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Charge movement associated with the opening and closing of the activation gates of the Na channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Activation by divalent cations of a Ca2+-activated K+ channel from skeletal muscle membrane

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Allosteric effects of Mg2+ on the gating of Ca2+-activated K+ channels from mammalian skeletal muscle.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Channel noise in nerve membranes and lipid bilayers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Sodium channels in nerve apparently have two conductance states

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Gating currents and charge movements in excitable membranes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5500982

Multiple regulatory sites in large-conductance calcium-activated potassium channels.

5 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

Mechanism of magnesium activation of calcium-activated potassium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

The variance of sodium current fluctuations at the node of Ranvier

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

Calibrated measurement of gating-charge arginine displacement in the KvAP voltage-dependent K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

Electrostatic tuning of ion conductance in potassium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

Survival of K+ permeability and gating currents in squid axons perfused with K+-free media

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

CTFFIND4: Fast and accurate defocus estimation from electron micrographs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

Ca-dependent K channels with large unitary conductance in chromaffin cell membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

China must provide education on HIV

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

Properties of single calcium-activated potassium channels in cultured rat muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

7 January 2021

Structural basis for gating the high-conductance Ca2+-activated K+ channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

7 January 2021

HOLLOW: generating accurate representations of channel and interior surfaces in molecular structures

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

7 January 2021

Empirical considerations regarding the use of ensemble-variance analysis of macroscopic currents

1 reference

https://api.crossref.org/works/10.1038%2FNATURE20608

7 January 2021

Identifiers

DOI

10.1038/NATURE20608

1 reference

Dimensions Publication ID

29 July 2017

0 references

1 reference

29 July 2017

1 reference