Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke (Q33879440)

29 July 2017

Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke (English)

1 reference

29 July 2017

Ruikang K Wang

5

1 reference

ORCID Public Data File 2021

Owen J T McCarty

8

object named as

Owen J T McCarty

1 reference

29 July 2017

Michelle A Berny-Lang

1

1 reference

29 July 2017

Sawan Hurst

2

1 reference

29 July 2017

Erik I Tucker

3

1 reference

29 July 2017

Leslie A Pelc

4

1 reference

29 July 2017

Patricia D Hurn

6

1 reference

29 July 2017

Enrico Di Cera

7

1 reference

29 July 2017

András Gruber

9

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29 July 2017

language of work or name

English

0 references

publication date

21 April 2011

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29 July 2017

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29 July 2017

42

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29 July 2017

6

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29 July 2017

1736-1741

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Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A

29 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Studies on the actin-binding protein HS1 in platelets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Thrombin as procoagulant and anticoagulant

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Neuroprotective effect of selective kappa opioid receptor agonist is gender specific and linked to reduced neuronal nitric oxide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Efficacy and safety of recombinant human activated protein C for severe sepsis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Recombinant tissue plasminogen activator reduces infarct size after reversible thread occlusion of middle cerebral artery in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Functional mapping of the surface residues of human thrombin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Tissue plasminogen activator for acute ischemic stroke

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3115697

The thrombin mutant W215A/E217A shows safe and potent anticoagulant and antithrombotic effects in vivo

29 October 2018

1 reference

12 December 2020

Three dimensional optical angiography

1 reference

12 December 2020

The Anticoagulant Thrombin Mutant W215A/E217A Has a Collapsed Primary Specificity Pocket

1 reference

12 December 2020

Rational design of a potent anticoagulant thrombin

1 reference

12 December 2020

tPA and proteolysis in the neurovascular unit

1 reference

12 December 2020

10.1161/STROKEAHA.110.603811

Identifiers

DOI

1 reference

release_ri3v47foxvcibbjsp43uaygwpm

29 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ri3v47foxvcibbjsp43uaygwpm

24 November 2022

mapped directly with Wikidata item

PMCID

3115697

1 reference

29 July 2017

1 reference