A model for assembly and activation of the GM-CSF, IL-3 and IL-5 receptors: insights from activated mutants of the common beta subunit (Q33864732)

29 July 2017

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title

A model for assembly and activation of the GM-CSF, IL-3 and IL-5 receptors: insights from activated mutants of the common beta subunit (English)

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29 July 2017

D'Andrea RJ

1

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PubMed ID

10720688

29 July 2017

Gonda TJ

series ordinal

2

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29 July 2017

1 March 2000

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29 July 2017

Experimental Hematology

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29 July 2017

28

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29 July 2017

3

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29 July 2017

231-243

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Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Cytokine receptors and signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Cytokine receptors and signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Hematopoietic receptor complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

A model for the interaction of the GM-CSF, IL-3 and IL-5 receptors with their ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Identification and expression cloning of a leptin receptor, OB-R

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Cytokine signal transduction and the JAK family of protein tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet?

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Jak2 is essential for signaling through a variety of cytokine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Janus kinases and their role in growth and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

The conserved box 1 motif of cytokine receptors is required for association with JAK kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Jaks and STATs: biological implications

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Cytokine signaling through nonreceptor protein tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Cytokine receptor signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Signaling mechanisms through cytokine receptors that share signal transducing receptor components

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Specificity of signaling by hematopoietic cytokine receptors: instructive versus permissive effects

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

STATs: signal transducers and activators of transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

JAK/STAT signaling by cytokine receptors

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Roles of JAK kinases in human GM-CSF receptor signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

A dominant negative granulocyte-macrophage colony-stimulating factor receptor alpha chain reveals the multimeric structure of the receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Functional replacement of cytokine receptor extracellular domains by leucine zippers

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Dysregulated hematopoiesis and a progressive neurological disorder induced by expression of an activated form of the human common beta chain in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Myeloproliferative disorder and leukaemia in mice induced by different classes of constitutive mutants of the human IL-3/IL-5/GM-CSF receptor common beta subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Reconstituted human granulocyte-macrophage colony-stimulating factor receptor transduces growth-promoting signals in mouse NIH 3T3 cells: comparison with signalling in BA/F3 pro-B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Reconstitution of the functional receptors for murine and human interleukin 5

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Interacting residues in the extracellular region of the common beta subunit of the human granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptors involved in constitutive activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

A cell type-specific constitutive point mutant of the common beta-subunit of the human granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5 receptors requires the GM-CSF receptor alpha-subunit for activation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Erythropoietin receptor activation by a ligand-induced conformation change

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

The beta subunit of human granulocyte-macrophage colony-stimulating factor receptor forms a homodimer and is activated via association with the alpha subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all thr

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Neu receptor dimerization

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three recepto

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Critical proline residues of the cytoplasmic domain of the IL-5 receptor alpha chain and its function in IL-5-mediated activation of JAK kinase and STAT5.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

A membrane-proximal region of the interleukin-2 receptor gamma c chain sufficient for Jak kinase activation and induction of proliferation in T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

The thrombopoietin receptor can mediate proliferation without activation of the Jak-STAT pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Interleukin-3 activates Syk in a human myeloblastic leukemia cell line, AML193.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

An epidermal growth factor receptor/Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Signal transduction by a CD16/CD7/Jak2 fusion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Signaling networks--do all roads lead to the same genes?

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Interaction of the erythropoietin and stem-cell-factor receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Growth hormone-induced tyrosine phosphorylation of EGF receptor as an essential element leading to MAP kinase activation and gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Erythropoietin induces tyrosine phosphorylation of the beta chain of the GM-CSF receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor alpha chain required for growth signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

A membrane proximal domain of the human interleukin-3 receptor beta c subunit that signals DNA synthesis in NIH 3T3 cells specifically binds a complex of Src and Janus family tyrosine kinases and phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

Structural basis for the binding of proline-rich peptides to SH3 domains

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900159-9

7 January 2021

10.1016/S0301-472X(99)00159-9

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10720688