Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation (Q33842772)

29 July 2017

Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation (English)

1 reference

29 July 2017

Jelena Todorovic

1

1 reference

29 July 2017

Brian T Welsh

2

1 reference

29 July 2017

Edward J Bertaccini

3

1 reference

29 July 2017

James R Trudell

4

1 reference

29 July 2017

S John Mihic

5

1 reference

29 July 2017

language of work or name

English

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publication date

12 April 2010

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Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

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29 July 2017

107

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29 July 2017

17

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29 July 2017

7987-7992

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Single-channel analysis of ethanol enhancement of glycine receptor function

29 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Mapping a molecular link between allosteric inhibition and activation of the glycine receptor.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Search for allosteric disulfide bonds in NMR structures

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

A stepwise mechanism for acetylcholine receptor channel gating

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Dynamics of the acetylcholine receptor pore at the gating transition state

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

The beta subunit determines the ligand binding properties of synaptic glycine receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Invariant aspartic Acid in muscle nicotinic receptor contributes selectively to the kinetics of agonist binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Molecular structure and function of the glycine receptor chloride channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Charged Residues in the β2 Subunit Involved in GABAA Receptor Activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Coupling of agonist binding to channel gating in the GABA(A) receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Hidden Markov modeling for single channel kinetics with filtering and correlated noise

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

A direct optimization approach to hidden Markov modeling for single channel kinetics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Mapping the conformational wave of acetylcholine receptor channel gating

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Kinetic properties of the glycine receptor main- and sub-conductance states of mouse spinal cord neurones in culture

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Thermal motions of surface alpha-helices in the D-galactose chemosensory receptor. Detection by disulfide trapping

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Principal pathway coupling agonist binding to channel gating in nicotinic receptors

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001845107

A highly conserved aspartic acid residue in the signature disulfide loop of the alpha 1 subunit is a determinant of gating in the glycine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001845107

Anesthetic and ethanol effects on spontaneously opening glycine receptor channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001845107

Occupancy of a single anesthetic binding pocket is sufficient to enhance glycine receptor function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001845107

Predicting the transmembrane secondary structure of ligand-gated ion channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001845107

Agonist-, antagonist-, and benzodiazepine-induced structural changes in the alpha1 Met113-Leu132 region of the GABAA receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001845107

Gating dynamics of the acetylcholine receptor extracellular domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001845107

Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1001845107

Mutations within the agonist-binding site convert the homomeric alpha1 glycine receptor into a Zn2+-activated chloride channel

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

Glycine and gamma-aminobutyric acid(A) receptor function is enhanced by inhaled drugs of abuse.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867890

29 October 2018

Identifiers

DOI

10.1073/PNAS.1001845107

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference